Breast Study Investigating a New Light Technique to Monitor Changes in Breast Tissue Density
Optical Quantification of Breast Density Changes Due to Hormone Treatment, Pregnancy and Breast-feeding.
5 other identifiers
observational
300
1 country
1
Brief Summary
The purpose of this study is to test the ability of a technique called Transillumination Breast Spectroscopy (TIBS) to monitor an individual's breast density changes over time.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started May 2004
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2004
CompletedFirst Submitted
Initial submission to the registry
September 9, 2005
CompletedFirst Posted
Study publicly available on registry
September 16, 2005
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2010
CompletedOctober 7, 2011
October 1, 2011
September 9, 2005
October 6, 2011
Conditions
Keywords
Eligibility Criteria
Cases recruited from the Reproductive Biology Unit at Mount Sinai Hospital and the University Health Network community. Controls recruited from University Health Network community and the University of Toronto community. (Toronto, Ontario, Canada)
You may qualify if:
- Be in good health and able to provide consent
- Be between 25 and 45 years of age
- Be pre-menopausal
- Are willing to come in to Princess Margaret Hospital (Toronto, Ontario, Canada) for up to 12 visits at intervals of about three months
You may not qualify if:
- Have had a full term pregnancy
- Have had breast biopsy
- Have had breast augmentation or reduction
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Ontario Cancer Institute, Princess Margaret Hospital
Toronto, Ontario, M5G 2M9, Canada
Related Publications (4)
Blyschak K, Simick M, Jong R, Lilge L. Classification of breast tissue density by optical transillumination spectroscopy: optical and physiological effects governing predictive value. Med Phys. 2004 Jun;31(6):1398-414. doi: 10.1118/1.1738191.
PMID: 15259643BACKGROUNDSimick MK, Jong R, Wilson B, Lilge L. Non-ionizing near-infrared radiation transillumination spectroscopy for breast tissue density and assessment of breast cancer risk. J Biomed Opt. 2004 Jul-Aug;9(4):794-803. doi: 10.1117/1.1758269.
PMID: 15250768BACKGROUNDBlackmore KM, Knight JA, Jong R, Lilge L. Assessing breast tissue density by transillumination breast spectroscopy (TIBS): an intermediate indicator of cancer risk. Br J Radiol. 2007 Jul;80(955):545-56. doi: 10.1259/bjr/26858614. Epub 2007 May 30.
PMID: 17537757BACKGROUNDSimick MK, Lilge L. Optical transillumination spectroscopy to quantify parenchymal tissue density: an indicator for breast cancer risk. Br J Radiol. 2005 Nov;78(935):1009-17. doi: 10.1259/bjr/14696165.
PMID: 16249602BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Lothar Lilge, PhD
Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada M5G 2M9; Department of Biophysics and Bioimaging, University of Toronto, Ontario, Canada M5G 2M9
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
September 9, 2005
First Posted
September 16, 2005
Study Start
May 1, 2004
Study Completion
September 1, 2010
Last Updated
October 7, 2011
Record last verified: 2011-10