NCT00186784

Brief Summary

Repetitive Transcranial Magnetic Stimulation (rTMS) can improve mood and decrease sadness in patients with depression. In this study, the investigators seek to increase their understanding about how rTMS improves depression, and to determine which form of rTMS is most effective for depression, when used in combination with antidepressant medication.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
21

participants targeted

Target at P25-P50 for early_phase_1

Timeline
Completed

Started Dec 2000

Longer than P75 for early_phase_1

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2000

Completed
4.8 years until next milestone

First Submitted

Initial submission to the registry

September 13, 2005

Completed
3 days until next milestone

First Posted

Study publicly available on registry

September 16, 2005

Completed
5.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2011

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2011

Completed
Last Updated

August 3, 2011

Status Verified

August 1, 2011

Enrollment Period

10.6 years

First QC Date

September 13, 2005

Last Update Submit

August 2, 2011

Conditions

Unipolar Depression

Keywords

Repetitive Transcranial Magnetic StimulationTMS

Outcome Measures

Primary Outcomes (2)

  • Hamilton Depression Rating Scale

    Pre TMS and post TMS

  • Beck Depression Rating Scale

    pre TMS and post TMS

Secondary Outcomes (1)

  • Quantitive Electroencephalographic(QEEG)activity and measures of regional cerebral blood flow

    pre TMS and post TMS as well as post phase II, second set of TMS

Interventions

Transcranial Magnetic Stimulation (TMS)PROCEDURE

treatment for 10 days

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Major Depression
  • No physical health problems

You may not qualify if:

  • History of Epilepsy
  • Metal in the head/neck or skull
  • Pacemaker
  • Pregnancy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

St.Joseph's Healthcare, rTMS Laboratory, Mood Disorders Program, 100 West Fifth Street

Hamilton, Ontario, L8N 3K7, Canada

Location

Related Publications (1)

  • Jacquot F, Khoury S, Labrum B, Delanoe K, Pidoux L, Barbier J, Delay L, Bayle A, Aissouni Y, Barriere DA, Kultima K, Freyhult E, Hugo A, Kosek E, Ahmed AS, Jurczak A, Lingueglia E, Svensson CI, Breuil V, Ferreira T, Marchand F, Deval E. Lysophosphatidylcholine 16:0 mediates chronic joint pain associated to rheumatic diseases through acid-sensing ion channel 3. Pain. 2022 Oct 1;163(10):1999-2013. doi: 10.1097/j.pain.0000000000002596. Epub 2022 Jan 27.

    PMID: 35086123DERIVED

MeSH Terms

Conditions

Depressive Disorder

Interventions

Transcranial Magnetic Stimulation

Condition Hierarchy (Ancestors)

Mood DisordersMental Disorders

Intervention Hierarchy (Ancestors)

Magnetic Field TherapyTherapeutics

Study Officials

  • Gary Hasey, MD

    McMaster University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
early phase 1
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER

Study Record Dates

First Submitted

September 13, 2005

First Posted

September 16, 2005

Study Start

December 1, 2000

Primary Completion

July 1, 2011

Study Completion

July 1, 2011

Last Updated

August 3, 2011

Record last verified: 2011-08

Locations

CA(1)