NCT00184873

Brief Summary

Leg ulcers are often chronic or recurring complications of peripheral circulation disorders. Patients' lifestyles are known to influence leg ulcer occurrence and circulation disorders in general. Especially exercise and compliance with compression therapy are key elements in the course of leg ulcer healing and recurrence. Yet many patients demonstrate sedentary lifestyles and non-compliance and current practice offers no systematic approach in the promotion of compliance and physical activity in these patients. The purpose of the study is testing 'Lively Legs' a compliance promotion program for patients with leg ulcers. The study tests the program on effects regarding:

  • compliance with compression therapy and exercise levels
  • time to leg ulcer recurrence
  • cost effectiveness from a social perspective.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
180

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jan 2005

Longer than P75 for not_applicable

Geographic Reach
1 country

11 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2005

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

September 12, 2005

Completed
4 days until next milestone

First Posted

Study publicly available on registry

September 16, 2005

Completed
2.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2008

Completed
7 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2008

Completed
Last Updated

February 9, 2010

Status Verified

August 1, 2007

Enrollment Period

3.3 years

First QC Date

September 12, 2005

Last Update Submit

February 8, 2010

Conditions

Keywords

randomized controlled trialhealth-counselingmulti-center study

Outcome Measures

Primary Outcomes (3)

  • * Compliance with compression therapy

    18 months

  • * Compliance with exercise prescriptions

    18 months

  • * Leg ulcer recurrence

    18 months

Secondary Outcomes (2)

  • * time to next ulcer / ulcer size and time to heal in case of recurrence /duration of ulcer free periods

    18 months

  • * evaluation of the cost effectiveness of the program

    18 months

Study Arms (2)

Lifestyle counseling

ACTIVE COMPARATOR

Patients receiving lifestyle counseling

Behavioral: Health Counseling

Regular care

NO INTERVENTION

Patients receiving regular care

Interventions

Lifestyle counseling

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Venous insufficiency
  • Venous and arterial insufficiency

You may not qualify if:

  • Total immobility
  • Insufficient mental capacity
  • Insufficient comprehension of the dutch language

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (11)

Slingeland ziekenhuis

Doetinchem, Gelderland, 7009BL, Netherlands

Location

Radboud University Nijmegen Medical Center

Nijmegen, Gelderland, 6500 HB, Netherlands

Location

Ziekenhuis Rivierenland

Tiel, Gelderland, 4002 WP, Netherlands

Location

Vie Curi

Venlo / Venray, Limburg, 5900 BX, Netherlands

Location

Jeroen Bosch ziekenhuis

's-Hertogenbosch, North Brabant, 5323 GV, Netherlands

Location

Elkerliek ziekenhuis

Deurne, North Brabant, 5751 CB, Netherlands

Location

St Anna ziekenhuis

Geldrop, North Brabant, 5664EH, Netherlands

Location

Bernhoven ziekenhuis

Veghel, North Brabant, 5461 AA, Netherlands

Location

IJssellandziekenhuis

Capelle aan den IJssel, South Holland, 2906 ZC, Netherlands

Location

University Medical Center Utrecht

Utrecht, Utrecht, 3584 CX, Netherlands

Location

ErasmusMC

Rotterdam, Zuide Holland, 3015 GJ, Netherlands

Location

Related Publications (7)

  • Heinen MM, van Achterberg T, op Reimer WS, van de Kerkhof PC, de Laat E. Venous leg ulcer patients: a review of the literature on lifestyle and pain-related interventions. J Clin Nurs. 2004 Mar;13(3):355-66. doi: 10.1046/j.1365-2702.2003.00887.x.

    PMID: 15009338BACKGROUND
  • Persoon A, Heinen MM, van der Vleuten CJ, de Rooij MJ, van de Kerkhof PC, van Achterberg T. Leg ulcers: a review of their impact on daily life. J Clin Nurs. 2004 Mar;13(3):341-54. doi: 10.1046/j.1365-2702.2003.00859.x.

    PMID: 15009337BACKGROUND
  • Bartholomew LK, Parcel GS, Kok G. Intervention mapping: a process for developing theory- and evidence-based health education programs. Health Educ Behav. 1998 Oct;25(5):545-63. doi: 10.1177/109019819802500502.

    PMID: 9768376BACKGROUND
  • Harper PL, Watson L, Bannon R. Compression ultrasonography for diagnosing deep vein thrombosis. Protocol is safe. BMJ. 1998 May 16;316(7143):1534; author reply 1535. No abstract available.

    PMID: 9616028BACKGROUND
  • Kan YM, Delis KT. Hemodynamic effects of supervised calf muscle exercise in patients with venous leg ulceration: a prospective controlled study. Arch Surg. 2001 Dec;136(12):1364-9. doi: 10.1001/archsurg.136.12.1364.

    PMID: 11735861BACKGROUND
  • Nelson EA, Bell-Syer SE, Cullum NA. Compression for preventing recurrence of venous ulcers. Cochrane Database Syst Rev. 2000;(4):CD002303. doi: 10.1002/14651858.CD002303.

    PMID: 11034749BACKGROUND
  • Yang D, Vandongen YK, Stacey MC. Effect of exercise on calf muscle pump function in patients with chronic venous disease. Br J Surg. 1999 Mar;86(3):338-41. doi: 10.1046/j.1365-2168.1999.00993.x.

    PMID: 10201775BACKGROUND

MeSH Terms

Conditions

Leg UlcerVaricose Ulcer

Condition Hierarchy (Ancestors)

Skin UlcerSkin DiseasesSkin and Connective Tissue DiseasesVaricose VeinsVascular DiseasesCardiovascular Diseases

Study Officials

  • Theo van Achterberg, RN, PhD

    IQ healthcare, Scientific Institute for Quality of healthcare, Radboud University Medical Centre, Nijmegen, The Netherlands

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

September 12, 2005

First Posted

September 16, 2005

Study Start

January 1, 2005

Primary Completion

May 1, 2008

Study Completion

December 1, 2008

Last Updated

February 9, 2010

Record last verified: 2007-08

Locations