NCT00184444

Brief Summary

The study investigates whether endurance training breathing 100% oxygen gives a additional improvement of maximal oxygen uptake in stable Angina Pectoris patients, compared to training without extra oxygen supplementation. In addition work economy, stroke volume and cardiac perfusion is measured. The hypothesis of the study is that increased oxygenation of the air increases performance, stroke volume, work economy and cardiac perfusion.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
25

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Sep 2004

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2004

Completed
1 year until next milestone

First Submitted

Initial submission to the registry

September 15, 2005

Completed
1 day until next milestone

First Posted

Study publicly available on registry

September 16, 2005

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2007

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2007

Completed
Last Updated

July 20, 2016

Status Verified

July 1, 2016

Enrollment Period

2.8 years

First QC Date

September 15, 2005

Last Update Submit

July 19, 2016

Conditions

Angina Pectoris

Keywords

angina pectorishyperoxiaendurance trainingstroke volumecardiac perfusion

Outcome Measures

Primary Outcomes (1)

  • maximal oxygen uptake

    Baseline and post training

Secondary Outcomes (3)

  • Cardiac perfusion

    Baseline and post training

  • work economy

    Baseline and post training

  • cardiac output

    baseline and post training

Study Arms (2)

Hypoxic Interval training

EXPERIMENTAL

4 x 4 minutes interval training with 100% oxygenated air

Behavioral: Hypoxic interval training

Normoxic interval training

EXPERIMENTAL

4 x 4 minutes interval training in normoxic air

Behavioral: Normoxic interval training

Interventions

Hypoxic interval trainingBEHAVIORAL

4 x 4 minutes interval training in hypoxic air, 3 times per week at 90-95% HR max

Hypoxic Interval training
Normoxic interval trainingBEHAVIORAL

4 x 4 minutes normoxic interval training, 3 times per week at 90-95% HR max

Normoxic interval training

Eligibility Criteria

Age18 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • stable angina pectoris age 18-75

You may not qualify if:

  • unstable angina pectoris
  • Limitations to exercise other than coronary artery disease
  • Participants in other study interventions

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Norwegian University of Science and Technology

Trondheim, 7489, Norway

Location

Related Publications (1)

  • Karlsen T, Hoff J, Stoylen A, Skovholdt MC, Gulbrandsen Aarhus K, Helgerud J. Aerobic interval training improves VO2 peak in coronary artery disease patients; no additional effect from hyperoxia. Scand Cardiovasc J. 2008 Oct;42(5):303-9. doi: 10.1080/14017430802032723.

    PMID: 18609057RESULT

MeSH Terms

Conditions

Angina PectorisHyperoxia

Condition Hierarchy (Ancestors)

Myocardial IschemiaHeart DiseasesCardiovascular DiseasesVascular DiseasesChest PainPainNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and SymptomsSigns and Symptoms, Respiratory

Study Officials

  • Asbjørn Støylen, MD

    Norwegian university of sience and technology

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 15, 2005

First Posted

September 16, 2005

Study Start

September 1, 2004

Primary Completion

July 1, 2007

Study Completion

July 1, 2007

Last Updated

July 20, 2016

Record last verified: 2016-07

Locations

NO(1)