Valproic Acid in the Induction of EBV Lytic Cycle Antigen Expression in Nasopharyngeal Carcinoma

NCT00181220 | Withdrawn Phase 1

• 1 other identifier: Valproic Acid NPC
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

The proposed study will test the safety and efficacy of sodium valproate in the induction of Epstein-Barr virus (EBV) lytic cycle antigen expression in tumor tissue of patients undergoing primary therapy for nasopharyngeal carcinoma. Up to 20 patients will be given valproic acid for 2 weeks. The primary surrogate endpoint for efficacy will be expression of EBV lytic antigens by immunohistochemistry in tumor tissue. Biopsies of primary tumor will be taken after 2 weeks with achievement of a therapeutic concentration of valproate. Expression of immunodominant EBV latency antigens in tumor tissue, EBV viral load by real time PCR, and valproate levels will be measured. Adverse events associated with valproate in NPC patients will be described.

Conditions

Nasopharyngeal Carcinoma

Outcome Measures

Primary Outcomes (1)

• expression of EBV lytic cycle antigens in NPC tumor tissue.

  2 weeks

Interventions

valproic acid DRUG

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• All subjects must fulfill the following criteria to be eligible for study admission:
• Subjects are of age 18 years and above
• Biopsy proven nasopharyngeal carcinoma - WHO type 3
• Must have tumor which is accessible to biopsy
• For patients with disease localized to the PNS, the lesion must be visualized by endoscopy
• Subjects with metastatic disease with disease accessible to biopsy in the PNS if they are deemed by their treating physicians not to require treatment for at least two weeks.
• An ECOG performance status of 0-2
• For sexually active women of child-bearing potential, negative pregnancy test within 14 days of enrolling on trial
• Must be able to give informed consent

You may not qualify if:

• For patients with localized NPC, PNS lesions that cannot be visualized by endoscopy
• Patients with disease inaccessible to biopsy
• History of anaphylaxis after exposure to valproic acid
• Hepatic dysfunction as defined by total bilirubin 1.0x upper limit of normal. AST (SGOT) and ALT (SGPT) 3x upper limit of normal
• Hemoglobin 8g/dl, Absolute neutrophil count 1500 cells/mm, and Platelet count 100,000 /mm
• Creatinine 3x upper limit of normal
• PT/PTT blood test result not within normal range
• Patients who require treatment with an anticonvulsant besides valproic acid during the course of valproate prescribed by the protocol
• ECOG Performance status 3-4
• Patients who are pregnant or breast feeding (Sexually active women of childbearing potential must use contraception during course of therapy and within 4 weeks of completion of trial)
• Participation in another clinical trial involving therapeutic intervention within 4 weeks of enrollment.

Sponsors & Collaborators

• Johns Hopkins University: lead
• National University Hospital of Singapore: collaborator

Study Sites (1)

Johns Hopkin Singapore International Medical Center

Singapore, Singapore

Location

MeSH Terms

Conditions

Nasopharyngeal Carcinoma

Interventions

Valproic Acid

Condition Hierarchy (Ancestors)

Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Nasopharyngeal Neoplasms; Pharyngeal Neoplasms; Otorhinolaryngologic Neoplasms; Head and Neck Neoplasms; Neoplasms by Site; Nasopharyngeal Diseases; Pharyngeal Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases

Intervention Hierarchy (Ancestors)

Pentanoic Acids; Valerates; Acids, Acyclic; Carboxylic Acids; Organic Chemicals; Fatty Acids, Volatile; Fatty Acids; Lipids

Study Officials

• Wen-son Hsieh, M.D.

  Johns Hopkins University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 13, 2005
• First Posted: September 16, 2005
• Study Start: April 1, 2004
• Study Completion: September 1, 2006
• Last Updated: May 18, 2020

Record last verified: 2019-05

Locations

SG (1)