NCT00180804

Brief Summary

For implantation of developing conceptus, placental cells need to invade mother's uterus to access maternal blood supply in a control manner. We have found a combination of maternal immune genes (the KIR family) and fetal genes (HLA-C) strongly associated with pre-eclampsia where placenta does not implant adequately. The aim of this research is to investigate these two genes family in women suffering with recurrent miscarriages and find a possible link between them.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
400

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Apr 2005

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2005

Completed
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

August 31, 2005

Completed
13 days until next milestone

First Submitted

Initial submission to the registry

September 13, 2005

Completed
3 days until next milestone

First Posted

Study publicly available on registry

September 16, 2005

Completed
Last Updated

October 16, 2023

Status Verified

October 1, 2023

First QC Date

September 13, 2005

Last Update Submit

October 13, 2023

Conditions

Recurrent Miscarriages

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Couples with 3 or more unexplained miscarriages

You may not qualify if:

  • Previous livebirths, parental karyotypic abnormalities, thrombophilic defects, uterine structural abnormalities

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

St. Mary's Hospital

London, W2 1NY, United Kingdom

Location

MeSH Terms

Conditions

Abortion, Habitual

Condition Hierarchy (Ancestors)

Abortion, SpontaneousPregnancy ComplicationsFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital Diseases

Study Officials

  • Ashley Moffett, MRCP

    University of Cambridge, UK

    PRINCIPAL INVESTIGATOR

  • Raj Rai, MRCOG

    Imperial College London

    PRINCIPAL INVESTIGATOR

  • Preeti Jindal, MRCOG

    St. Mary's NHS Trust, London

    PRINCIPAL INVESTIGATOR

  • Winnie Lo

    St. Mary's NHS Trust, London

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Time Perspective
OTHER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 13, 2005

First Posted

September 16, 2005

Study Start

April 1, 2005

Study Completion

August 31, 2005

Last Updated

October 16, 2023

Record last verified: 2023-10

Locations

GB(1)