Study of Breath-holding as a Means to Reduce Tumor Motion From Breathing

NCT00178477 | Terminated Results

• 1 other identifier: URCC 3701
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this research study is to evaluate typical tumor motion caused by breathing using MRI and can help determine whether simple passive breathing and/or breath-holding could be used for the future treatment of similar lung and liver tumors using radiation therapy radiosurgery techniques.

Conditions

Neoplasm, Metastatic

Outcome Measures

Primary Outcomes (1)

• Tumor Motion Related to Breathing as Determined From MRI Images

  1. Determine the typical and maximal tumor 3D displacements over the respiratory cycle and how these values vary depending on the tumor location 2. Determine the reproducibility of target position over multiple breath-holds 3. Determine the variability across patients in respiratory-derived lesion motion and target position reproducibility over multiple breath-holds

  20 - 30 seconds

Study Arms (1)

Breath-holding

EXPERIMENTAL

MRI with breath-holding

Procedure: MRI with breath-holding

Interventions

MRI with breath-holding PROCEDURE

Breath holding for diminished tumor motion.

Breath-holding

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• The patient is enrolled on U8700 RSRB # A Phase II Study For Using Radiosurgery On Limited Metastases Of Breast Cancer or U9700 A Pilot Study For Using Radiosurgery On Limited Metastases.
• ≥ 18 years of age
• has given Informed consent

You may not qualify if:

• Contraindications for any MRI procedure

Sponsors & Collaborators

• University of Rochester: lead

Study Sites (1)

University of Rochester Department of Radiation Oncology

Rochester, New York, 14642, United States

Location

MeSH Terms

Conditions

Neoplasm Metastasis

Interventions

Magnetic Resonance Spectroscopy; Breath Holding

Condition Hierarchy (Ancestors)

Neoplastic Processes; Neoplasms; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Spectrum Analysis; Chemistry Techniques, Analytical; Investigative Techniques; Respiration; Respiratory Physiological Phenomena; Circulatory and Respiratory Physiological Phenomena

Results Point of Contact

• Title: Walter O'Dell, Ph.D.
• Organization: University of Rochester Medical Center

walter_odell@urmc.rochester.edu

585-275-9996

Study Officials

• Walter O'Dell, PhD

  University of Rochester

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 13, 2005
• First Posted: September 15, 2005
• Study Start: January 1, 2002
• Primary Completion: January 1, 2011
• Study Completion: January 1, 2011
• Last Updated: April 19, 2013
• Results First Posted: April 19, 2013

Record last verified: 2013-04

Locations

US (1)