NCT00178165

Brief Summary

Established in 1995, Resources for Enhancing Alzheimer's Caregiver Health (REACH) is a unique, multi-site research program sponsored by the National Institute on Aging (NIA) and the National Institute on Nursing Research (NINR). The primary purpose of REACH is to carry out social and behavioral research on interventions designed to enhance family caregiving for Alzheimer's disease and related disorders. Specifically, REACH has two goals: to test the effectiveness of multiple different interventions and to evaluate the pooled effect of REACH interventions overall. REACH grew out of a National Institute of Health (NIH) initiative that acknowledged the well-documented burdens associated with family caregiving as well as the existence of promising family caregiver interventions reported in the literature.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,200

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Sep 1996

Longer than P75 for not_applicable

Geographic Reach
1 country

5 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 1996

Completed
5.2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2001

Completed
3.9 years until next milestone

First Submitted

Initial submission to the registry

September 13, 2005

Completed
2 days until next milestone

First Posted

Study publicly available on registry

September 15, 2005

Completed
Last Updated

September 15, 2005

Status Verified

September 1, 2005

First QC Date

September 13, 2005

Last Update Submit

September 13, 2005

Conditions

DementiaAlzheimer Disease

Keywords

Family CaregiversDementiaAlzheimer DiseaseRandomized Controlled TrialIntervention Studies

Outcome Measures

Primary Outcomes (2)

  • The outcomes were assessed 6 months after randomization and included a measure of burden and a measure of depression. Caregiver burden was assessed using the Revised Memory and Behavior Problem Checklist (RMBPC).

  • Emotional distress was determined by the Center for Epidemiological Studies Depression Scale (CES-D) a global measure of depression.

Secondary Outcomes (3)

  • Long-term care placement of dementia patients and caregiver health and well-being

  • Use of cognitive enhancement medication

  • Clinical significance of caregiver interventions in diverse populations

Interventions

Skill Training Condition - problem solving trainingPROCEDURE
REACH for TLC (Telephone Linked Computer) systemPROCEDURE

Eligibility Criteria

Age21 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may not qualify if:

  • NINCDS -ADRDA Criteria for Alzheimer's Disease and/or DSM IV Criteria for Alzheimer's Disease or other dementia or MMSE score \< 23.
  • Functional impairment: presence of two IADL or one ADL impairments.
  • Any terminal illness with life expectancy \< 6 months
  • Active treatment (chemotherapy, radiation therapy) for cancer
  • More than three acute medical hospitalizations in past year (not for psychiatric or Alzheimer's Disease related admission)
  • Schizophrenia (onset of delusions before age 45)
  • Dementia secondary to head trauma (probable)
  • Blindness or deafness if either disability prohibits them from completion of data collection or participation in the interventions
  • MMSE = 0 and bedbound (confined to a bed or chair for \> 22 hours per day, for at least 4 of the past 7 days)
  • Planned nursing home admission in 6 months
  • Age: 21 years and older
  • Language: site specific, must be competent either orally or written
  • Lives with care recipient
  • Family member
  • Gender: Palo Alto/Los Angeles will only enroll women. All other sites will enroll men and women
  • +10 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (5)

University of Alabama at Birmingham

Birmingham, Alabama, 35294-2041, United States

Location

Stanford University and Veterans Affairs

Menlo Park, California, 94025, United States

Location

University of Miami at Miami, Center on Adult Development and Aging

Miami, Florida, 33136, United States

Location

Thomas Jefferson University at Philadelphia, Center for Applied Research on Aging and Health

Philadelphia, Pennsylvania, 19107, United States

Location

University of Tennessee Health Science Center

Memphis, Tennessee, 38163, United States

Location

Related Publications (12)

  • Belle SH, Czaja SJ, Schulz R, Zhang S, Burgio LD, Gitlin LN, Jones R, Mendelsohn AB, Ory MG; REACH Investigators. Using a new taxonomy to combine the uncombinable: integrating results across diverse interventions. Psychol Aging. 2003 Sep;18(3):396-405. doi: 10.1037/0882-7974.18.3.396.

    PMID: 14518803RESULT

  • Czaja SJ, Schulz R, Lee CC, Belle SH; REACH Investigators. A methodology for describing and decomposing complex psychosocial and behavioral interventions. Psychol Aging. 2003 Sep;18(3):385-95. doi: 10.1037/0882-7974.18.3.385.

    PMID: 14518802RESULT

  • Wisniewski SR, Belle SH, Coon DW, Marcus SM, Ory MG, Burgio LD, Burns R, Schulz R; REACH Investigators. The Resources for Enhancing Alzheimer's Caregiver Health (REACH): project design and baseline characteristics. Psychol Aging. 2003 Sep;18(3):375-84. doi: 10.1037/0882-7974.18.3.375.

    PMID: 14518801RESULT

  • Gitlin LN, Belle SH, Burgio LD, Czaja SJ, Mahoney D, Gallagher-Thompson D, Burns R, Hauck WW, Zhang S, Schulz R, Ory MG; REACH Investigators. Effect of multicomponent interventions on caregiver burden and depression: the REACH multisite initiative at 6-month follow-up. Psychol Aging. 2003 Sep;18(3):361-74. doi: 10.1037/0882-7974.18.3.361.

    PMID: 14518800RESULT

  • Schulz R, Belle SH, Czaja SJ, Gitlin LN, Wisniewski SR, Ory MG; REACH Investigators. Introduction to the special section on Resources for Enhancing Alzheimer's Caregiver Health (REACH). Psychol Aging. 2003 Sep;18(3):357-60. doi: 10.1037/0882-7974.18.3.357.

    PMID: 14518799RESULT

  • Gallagher-Thompson D, Coon DW, Solano N, Ambler C, Rabinowitz Y, Thompson LW. Change in indices of distress among Latino and Anglo female caregivers of elderly relatives with dementia: site-specific results from the REACH national collaborative study. Gerontologist. 2003 Aug;43(4):580-91. doi: 10.1093/geront/43.4.580.

    PMID: 12937336RESULT

  • Burgio L, Stevens A, Guy D, Roth DL, Haley WE. Impact of two psychosocial interventions on white and African American family caregivers of individuals with dementia. Gerontologist. 2003 Aug;43(4):568-79. doi: 10.1093/geront/43.4.568.

    PMID: 12937335RESULT

  • Mahoney DF, Tarlow BJ, Jones RN. Effects of an automated telephone support system on caregiver burden and anxiety: findings from the REACH for TLC intervention study. Gerontologist. 2003 Aug;43(4):556-67. doi: 10.1093/geront/43.4.556.

    PMID: 12937334RESULT

  • Burns R, Nichols LO, Martindale-Adams J, Graney MJ, Lummus A. Primary care interventions for dementia caregivers: 2-year outcomes from the REACH study. Gerontologist. 2003 Aug;43(4):547-55. doi: 10.1093/geront/43.4.547.

    PMID: 12937333RESULT

  • Gitlin LN, Winter L, Corcoran M, Dennis MP, Schinfeld S, Hauck WW. Effects of the home environmental skill-building program on the caregiver-care recipient dyad: 6-month outcomes from the Philadelphia REACH Initiative. Gerontologist. 2003 Aug;43(4):532-46. doi: 10.1093/geront/43.4.532.

    PMID: 12937332RESULT

  • Eisdorfer C, Czaja SJ, Loewenstein DA, Rubert MP, Arguelles S, Mitrani VB, Szapocznik J. The effect of a family therapy and technology-based intervention on caregiver depression. Gerontologist. 2003 Aug;43(4):521-31. doi: 10.1093/geront/43.4.521.

    PMID: 12937331RESULT

  • Schulz R, Burgio L, Burns R, Eisdorfer C, Gallagher-Thompson D, Gitlin LN, Mahoney DF. Resources for Enhancing Alzheimer's Caregiver Health (REACH): overview, site-specific outcomes, and future directions. Gerontologist. 2003 Aug;43(4):514-20. doi: 10.1093/geront/43.4.514. No abstract available.

    PMID: 12937330RESULT

Related Links

MeSH Terms

Conditions

DementiaAlzheimer Disease

Interventions

Drug Delivery Systems

Condition Hierarchy (Ancestors)

Brain DiseasesCentral Nervous System DiseasesNervous System DiseasesNeurocognitive DisordersMental DisordersTauopathiesNeurodegenerative Diseases

Intervention Hierarchy (Ancestors)

Drug TherapyTherapeutics

Study Officials

  • Richard Schulz, Ph.D.

    Professor of Psychiatry and Director, University Center for Social and Urban Research, University of Pittsburgh

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

September 13, 2005

First Posted

September 15, 2005

Study Start

September 1, 1996

Study Completion

November 1, 2001

Last Updated

September 15, 2005

Record last verified: 2005-09

Locations

US(5)