NCT00175227|Completed
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Sponsor study identifier
interventional
200
1 country
1
Study Start
May 1996
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
October 2000
Actual (reported)Study Completion
Not reported
Date not reportedPatients with pre-existing kidney disease are at high risk of acute renal failure when exposed to radio-contrast dyes, for example during a cardiac angiogram. The investigators hypothesize that an infusion of saline + furosemide + mannitol will reduce rates of contrast-induced nephropathy when compared with saline infusion controls.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
Not reported
Date not reportedClick on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 1996
Date type not reportedThis date has not been verified as actual or estimated.
October 2000
Actual (reported)September 10, 2005
Actual (reported)September 15, 2005
Actual (reported)Proportion of patients that develop contrast-induced nephropathy after cardiac angiography
Within 48 hours of angiogram
Safety of the intervention based on transfer to ICU, need for dialysis, or death
During hospitalization episode
Adverse clinical events and measures of renal function
6 weeks post-angiogram
Saline hydration + mannitol + furosemide
Saline hydration without mannitol or furosemide
500 mls half-normal saline + 25g mannitol + 100 mg furosemide
500 mls half-normal saline
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
These entries preserve how the registry describes the intervention. Their treatment roles are shown separately from molecular identities.
Grouped treatment entry
intravenous saline hydration + mannitol + furosemide
The registry names several treatments. This does not confirm that participants received them together or that they form a single product.
View registry recordUniversity of Alberta Hospitals
Edmonton, Alberta, T6G 2B7, Canada
Majumdar SR, Kjellstrand CM, Tymchak WJ, Hervas-Malo M, Taylor DA, Teo KK. Forced euvolemic diuresis with mannitol and furosemide for prevention of contrast-induced nephropathy in patients with CKD undergoing coronary angiography: a randomized controlled trial. Am J Kidney Dis. 2009 Oct;54(4):602-9. doi: 10.1053/j.ajkd.2009.03.024. Epub 2009 Jun 17.
Hashimoto H, Yamada H, Murata M, Watanabe N. Diuretics for preventing and treating acute kidney injury. Cochrane Database Syst Rev. 2025 Jan 29;1(1):CD014937. doi: 10.1002/14651858.CD014937.pub2.
Sumit R Majumdar, MD, MPH
University of Alberta
First Submitted
September 10, 2005
First Posted
September 15, 2005
Study Start
May 1996
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
October 2000
Examining the Impact of Using Two Dialysers in Parallel on Dialysis Adequacy in Hemodialysis Patients
Health related quality of life
6 weeks post-angiogram
Subgroup analyses based on (a) diabetes; (b) amount of contrast; and (c) baseline creatinine
Within 48 hours of angiogram
Contact the study team to confirm eligibility.
Last Updated
May 10, 2011
Record last verified: 2011-05
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Source: ClinicalTrials.gov.
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