NCT00169364

Brief Summary

Parkinson's disease is a frequent neurodegenerative disorder. Genetic forms of the disease have been recently identified. The monogenic form due to parkin mutation is responsible for many familial cases and sporadic forms. However, the relationship between the mutation and the genotype of patients is not fully established. The aim of this study is to compare clinical, metabolic and neuropsychological characteristics obtained in patients with parkin mutation with those of patients without parkin mutation.

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50

participants targeted

Target at P25-P50 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2002

Completed
3.4 years until next milestone

First Submitted

Initial submission to the registry

September 12, 2005

Completed
3 days until next milestone

First Posted

Study publicly available on registry

September 15, 2005

Completed
Last Updated

August 29, 2007

Status Verified

September 1, 2005

First QC Date

September 12, 2005

Last Update Submit

August 28, 2007

Conditions

Parkinson's Disease

Keywords

Parkinson's diseaseparkin mutationJuvenile parkinson's diseasepositron emission tomography

Outcome Measures

Primary Outcomes (4)

  • Parkin mutation

  • Motor disability

  • Neuropsychological evaluation

  • Psychiatric evaluation

Secondary Outcomes (1)

  • Positron emission tomography

Interventions

positron emission tomographyDEVICE

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Juvenile Parkinson's disease (\< 45 years)
  • Parkin mutation
  • Normal brain magnetic resonance imaging (MRI)

You may not qualify if:

  • Contraindication to brain MRI
  • Women without effective contraception

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Centre d'Investigation Clinique-Hôpital Pitié-Salpetriere

Paris, France

RECRUITING

MeSH Terms

Conditions

Parkinson DiseaseParkinsonian Disorders

Interventions

Positron-Emission Tomography

Condition Hierarchy (Ancestors)

Basal Ganglia DiseasesBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesMovement DisordersSynucleinopathiesNeurodegenerative Diseases

Intervention Hierarchy (Ancestors)

Tomography, Emission-ComputedImage Interpretation, Computer-AssistedDiagnostic ImagingDiagnostic Techniques and ProceduresDiagnosisImage EnhancementPhotographyRadionuclide ImagingTomographyDiagnostic Techniques, Radioisotope

Study Officials

  • Alexis Brice, MD, PhD

    Groupe Hospitalier Pitié-Salpêtrière

    STUDY DIRECTOR

Central Study Contacts

Alexis Brice, MD, PhD

CONTACT

33-142162183brice@ccr.jussieu.fr

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
DIAGNOSTIC
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

September 12, 2005

First Posted

September 15, 2005

Study Start

May 1, 2002

Last Updated

August 29, 2007

Record last verified: 2005-09

Locations

FR(1)