Different Doses of Vitamin A Supplementation and Male and Female Morbidity and Mortality
The Impact of Different Doses of Vitamin A Supplementation on Male and Female Childhood Morbidity and Mortality
2 other identifiers
interventional
11,000
1 country
1
Brief Summary
We previously compared the effect on mortality of the half dose and the full dose currently recommended by WHO. Unexpectedly, the low dose was clearly better for girls, but not for boys. The girls' response might have depended on the last vaccine received before the OPV and VAS campaign. We believe that these findings call for confirmation. In connection with a new campaign, we will examine whether half the dose or the full dose has a more beneficial effect on mortality and morbidity in girls, and furthermore address the potential effect modification by the last vaccine received before the supplementation.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_4
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 1, 2004
CompletedFirst Submitted
Initial submission to the registry
September 12, 2005
CompletedFirst Posted
Study publicly available on registry
September 15, 2005
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2013
CompletedNovember 15, 2013
November 1, 2013
9 years
September 12, 2005
November 14, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Mortality
Morbidity
All outcomes are investigated for interactions between vitamin A, sex, and last vaccine received
Secondary Outcomes (3)
Rota infection
Measles infection
Growth
Interventions
Eligibility Criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Bandim Health Project, Apartado 861
Bissau, Guinea-Bissau
Related Publications (1)
Yakymenko D, Benn CS, Martins C, Diness BR, Fisker AB, Rodrigues A, Aaby P. The impact of different doses of vitamin A supplementation on male and female mortality. A randomised trial from Guinea-Bissau. BMC Pediatr. 2011 Sep 1;11:77. doi: 10.1186/1471-2431-11-77.
PMID: 21884606DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Peter Aaby, DMSc
Bandim Health Project
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
September 12, 2005
First Posted
September 15, 2005
Study Start
November 1, 2004
Primary Completion
November 1, 2013
Last Updated
November 15, 2013
Record last verified: 2013-11