Screening for Colorectal Neoplasm in First Degree Relatives of the Affected

NCT00164944 | Completed

• 1 other identifier: FDR
• Study Type: observational
• Target: 748
• Locations: 1 country
• Sites: 1

Brief Summary

To determine the prevalence of colorectal neoplasms in first degree relatives of those affected with sporadic colorectal cancer using colonoscopy as a screening tool. The prevalence will be compared to that of a defined matched cohort.

Conditions

Colorectal Cancer Screening

Keywords

Colonoscopy; First degree relatives

Outcome Measures

Primary Outcomes (1)

• To find the prevalence of adenomas and advanced neoplasms of the first degree relatives

  7 years

Study Arms (2)

FDR of CRC patient

First degree relatives of patients having CRC

Procedure: Colonoscopy

FDR of normal colonoscopy

First degree relatives of patients having normal colonoscopy

Procedure: Colonoscopy

Interventions

Colonoscopy PROCEDURE

To determine the adenomas during colonoscopy

FDR of CRC patient

Eligibility Criteria

• Age: 40 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

First degree relatives of patients having CRC or patient having normal colonoscopy

You may qualify if:

• First degree relatives (age \>40 and \<70) of individuals affected with sporadic colorectal cancer (those not associated with inflammatory bowel disease, familial adenomatous polyposis or HNPCC syndrome).

You may not qualify if:

• A family history compatible with that of Hereditary Non-polyposis Colon Cancer (HNPCC) based on the Amsterdam criteria \[Table 5\].
• Known Familial Adenomatous Polyposis (FAP) syndrome
• Patients and relatives with known inflammatory bowel disease
• Severe cardio-pulmonary or other medical co-morbidities that preclude safe colonoscopic examination

Sponsors & Collaborators

• Chinese University of Hong Kong: lead

Study Sites (1)

Endoscopy Center, Prince of Wales Hospital

Hong Kong (sar), China

Location

Related Publications (1)

• Ng SC, Lau JY, Chan FK, Suen BY, Leung WK, Tse YK, Ng SS, Lee JF, To KF, Wu JC, Sung JJ. Increased risk of advanced neoplasms among asymptomatic siblings of patients with colorectal cancer. Gastroenterology. 2013 Mar;144(3):544-50. doi: 10.1053/j.gastro.2012.11.011. Epub 2012 Nov 13.

  PMID: 23159367 DERIVED

MeSH Terms

Interventions

Colonoscopy

Intervention Hierarchy (Ancestors)

Endoscopy, Gastrointestinal; Endoscopy, Digestive System; Diagnostic Techniques, Digestive System; Diagnostic Techniques and Procedures; Diagnosis; Endoscopy; Diagnostic Techniques, Surgical; Digestive System Surgical Procedures; Surgical Procedures, Operative; Minimally Invasive Surgical Procedures

Study Officials

• James Y Lau, MD

  Prince of Wales Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 9, 2005
• First Posted: September 14, 2005
• Study Start: April 1, 2004
• Primary Completion: August 1, 2016
• Study Completion: April 6, 2017
• Last Updated: April 21, 2017

Record last verified: 2017-04

Locations

CN (1)