NCT00161889

Brief Summary

The purpose of this study is to investigate the safety and immunogenicity of the third vaccination with one of three different concentrations of a TBE vaccine in all volunteers who completed two vaccinations in one of the three treatment groups of Baxter study 205 (safety and immunogenicity of two vaccinations with FSME IMMUN NEW in healthy volunteers aged 6 to 16 years).

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
615

participants targeted

Target at P75+ for phase_2

Timeline
Completed

Started Feb 2002

Shorter than P25 for phase_2

Geographic Reach
1 country

19 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 2002

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2002

Completed
3.1 years until next milestone

First Submitted

Initial submission to the registry

September 8, 2005

Completed
5 days until next milestone

First Posted

Study publicly available on registry

September 13, 2005

Completed
Last Updated

May 21, 2015

Status Verified

May 1, 2015

First QC Date

September 8, 2005

Last Update Submit

May 20, 2015

Conditions

Interventions

Eligibility Criteria

Age6 Years - 16 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • All volunteers who participated in Baxter study 205 and received two vaccinations will be invited to participate. Male and female children will be eligible for participation in this study if:
  • They received two vaccinations with one of the three different dosages of FSME IMMUN NEW during the course of Baxter study 205
  • They and/or their legal guardian understand the nature of the study, agree to its provisions and give written informed consent

You may not qualify if:

  • Volunteers will be excluded from vaccination and consecutive visits in this study if they:
  • Are not clinically healthy, (i. e. the physician would have reservations vaccinating with FSME IMMUN NEW outside the scope of a clinical trial)
  • Have already been administered a third TBE vaccination elsewhere after the two vaccinations in Baxter study 205
  • Have had an allergic reaction to one of the components of the vaccine since the last vaccination in Baxter study 205
  • Suffer from a disease (e.g. autoimmune disease) or are undergoing a form of treatment (e.g. systemic corticosteroids, chemotherapeutics) that can be expected to influence immunological functions
  • Have received banked human blood or immunoglobulins within one month of study entry
  • Are known to be HIV positive (a special HIV test is not required for the purpose of the study) since the last visit of Baxter study 205
  • Have had a vaccination against yellow fever and / or Japanese B-encephalitis since the last visit in Baxter study 205
  • Had received an investigational new drug within 6 weeks prior to study start
  • If female and capable of bearing children - have a positive pregnancy test at the first medical examination

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (19)

Neuschwanstein Strasse 5

Augsburg, D-86163, Germany

Location

Marktplatz 33

Bad Saulgau, D-88348, Germany

Location

Hauptstrasse 9

Bietigheim-Bissingen, D-74321, Germany

Location

Salzgasse 11

Calw, D-75365, Germany

Location

Mohrenstrasse 8

Coburg, D-96450, Germany

Location

Bahnhofstrasse 1

Elzach, D-79215, Germany

Location

Rheinstrasse 1a

Ettenheim, D-77955, Germany

Location

Peter-Seifert Strasse 5

Gersfeld, D-36129, Germany

Location

Solothumer Strasse 2

Heilbronn, D-74072, Germany

Location

Hauptstrasse 240

Kehl, D-77694, Germany

Location

Schwarzwald Strasse 20

Kirchzarten, D-79199, Germany

Location

Altoettinger Strasse 3

Landsberg, D-86899, Germany

Location

Rastatter Strasse 7

Mannheim-Secken, 68239, Germany

Location

Wilhelmstrasse 25

Metzingen, D-72555, Germany

Location

Dohmbuehler Strasse 8

Nuremberg, D-90449, Germany

Location

Wilhelmstrasse 7

Offenburg, D-77654, Germany

Location

Berneckstrasse 19

Schramberg, D-78713, Germany

Location

Hauptstrasse 11

Tegernsee, D-83681, Germany

Location

Broner Platz 6

Weingarten, D-88250, Germany

Location

MeSH Terms

Conditions

Encephalitis, Tick-Borne

Interventions

Vaccines

Condition Hierarchy (Ancestors)

Encephalitis, ArbovirusEncephalitis, ViralCentral Nervous System Viral DiseasesCentral Nervous System InfectionsInfectionsInfectious EncephalitisArbovirus InfectionsVector Borne DiseasesTick-Borne DiseasesVirus DiseasesRNA Virus InfectionsFlavivirus InfectionsFlaviviridae InfectionsEncephalitisBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesNeuroinflammatory Diseases

Intervention Hierarchy (Ancestors)

Biological ProductsComplex Mixtures

Study Officials

  • Baxter BioScience Investigator

    Baxter Healthcare Corporation

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
DOUBLE
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

September 8, 2005

First Posted

September 13, 2005

Study Start

February 1, 2002

Study Completion

August 1, 2002

Last Updated

May 21, 2015

Record last verified: 2015-05

Locations