NCT00161109

Brief Summary

The purposes of this study are to:

  1. 1.study the nature and longitudinal course of psychiatric symptoms in children with the 22q11.2 deletion syndrome and
  2. 2.identify genes that contribute to the occurrence of these symptoms.

Trial Health

47
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
175

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Oct 2002

Longer than P75 for all trials

Geographic Reach
2 countries

2 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2002

Completed
2.9 years until next milestone

First Submitted

Initial submission to the registry

September 8, 2005

Completed
4 days until next milestone

First Posted

Study publicly available on registry

September 12, 2005

Completed
7.1 years until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2012

Completed
Last Updated

October 13, 2006

Status Verified

October 1, 2004

First QC Date

September 8, 2005

Last Update Submit

October 12, 2006

Conditions

Chromosome 22q11.2 Deletion Syndrome

Keywords

22q11.2 deletion syndromePsychopathologyPsychiatryNeuropsychologyPsychiophysiologyAutismPsychosisDeletion sizeCandidate genesPsychiatric symptomsNeuropsychological impairmentsPsychophysiological performance

Eligibility Criteria

Age8 Years - 20 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • q11.2 deletion confirmed with fluorescence in-situ hybridization (FISH)

You may not qualify if:

  • None

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Children's Hospital of Philadelphia, Dpt of Genetics and Dpt of Child and Adolescent Psychiatry

Philadelphia, Pennsylvania, 19104, United States

RECRUITING

UMC Utrecht, Dpt of Child and Adolescent Psychiatry

Utrecht, 3508 GA, Netherlands

RECRUITING

MeSH Terms

Conditions

DiGeorge SyndromeAutistic DisorderPsychotic Disorders

Condition Hierarchy (Ancestors)

22q11 Deletion SyndromeCraniofacial AbnormalitiesMusculoskeletal AbnormalitiesMusculoskeletal DiseasesHeart Defects, CongenitalCardiovascular AbnormalitiesCardiovascular DiseasesHeart DiseasesLymphatic AbnormalitiesLymphatic DiseasesHemic and Lymphatic DiseasesAbnormalities, MultipleCongenital AbnormalitiesCongenital, Hereditary, and Neonatal Diseases and AbnormalitiesChromosome DisordersGenetic Diseases, InbornHypoparathyroidismParathyroid DiseasesEndocrine System DiseasesAutism Spectrum DisorderChild Development Disorders, PervasiveNeurodevelopmental DisordersMental DisordersSchizophrenia Spectrum and Other Psychotic Disorders

Study Officials

  • René S. Kahn, M.D., Ph.D.

    UMC Utrecht, The Netherlands

    STUDY DIRECTOR

Central Study Contacts

Jacob AS Vorstman, M.D.

CONTACT

215 590 3863J.A.S.Vorstman@azu.nl

Study Design

Study Type
observational
Observational Model
DEFINED POPULATION
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

September 8, 2005

First Posted

September 12, 2005

Study Start

October 1, 2002

Study Completion

October 1, 2012

Last Updated

October 13, 2006

Record last verified: 2004-10

Locations

NL(1)US(1)