Characterizing and Diagnosis's of the Charcot Foot (Charcot Osteoarthropathy) in Diabetic Patients

NCT00157222 | Unknown

• 1 other identifier: (KF) 01 2587558
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The condition Charcot foot has been known in more than 130 years, and yet there still remains a large effort to find the cause, diagnostic and medical treatment of the condition. Charcot neuroarthropathy is a progressive disease of bone and joints characterized by often-painless bone and joint destruction in limbs that have lost sensory innervation. The incidence of acute Charcot among diabetic patients is 0,2 % the prevalence is 7,5 %. In the group of patients with neuropathy the prevalence is even higher -29%. The diagnosis is often made on a clinical basis, particularly in the early stages of the condition. The aim of this study is to find a method that makes the diagnosis primarily on the basis of paraclinical information. Clinical presentation: The typical patients have had diabetes in 10 years and have distal symmetrical neuropathy. The common lesion is unilateral with an acute phase, which may occur either spontaneously or be triggered by a minor trauma. The foot becomes swollen, warm, red and oedematous. Some patients have pain, and the condition could be misdiagnosed as cellulites, acute gout, deep vein thrombosis and osteomyelitis. If the patient has a foot ulcer it is important to rule out osteomyelitis and cellulites. In the initial phase it is difficult to make the right diagnose because Charcot is a rare condition. This leads to a delay in the treatment of the Charcot foot, which, for the moment, is reduction of weight bearing. The patient is equipped with an air cast, and the non weight-bearing regime is in some cases maintained in 12 months. The chronic Charcot is characterized by established deformity. The deformity can be in different sites in the foot, the most common is in the mid foot. Because of the deformity there is abnormal weight pressure on the weight bearing sites on the foot. This is associated with callus formation and there is a higher risk for ulceration.

Conditions

Charcot Joint; Diabetic Foot

Keywords

Charcot; Diabetic; osteoporosis

Eligibility Criteria

• Age: 0 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Acute Charcot
• Chronic Charcot
• Polyneuropathy
• Operation of the foot

You may not qualify if:

• Pregnancy
• Infection of the foot
• Impert blood flow in the leg.

Sponsors & Collaborators

• Bispebjerg Hospital: lead
• H. Lundbeck A/S: collaborator
• The Danish Diabetes Association: collaborator
• Clinical and basic research ballerup: collaborator
• Steno Diabetes Center Copenhagen: collaborator

Study Sites (1)

Bispebjerg Hospital

Copenhagen, 2200, Denmark

RECRUITING

MeSH Terms

Conditions

Arthropathy, Neurogenic; Diabetic Foot; Osteoporosis

Condition Hierarchy (Ancestors)

Joint Diseases; Musculoskeletal Diseases; Diabetic Angiopathies; Vascular Diseases; Cardiovascular Diseases; Foot Ulcer; Leg Ulcer; Skin Ulcer; Skin Diseases; Skin and Connective Tissue Diseases; Diabetes Complications; Diabetes Mellitus; Endocrine System Diseases; Diabetic Neuropathies; Bone Diseases, Metabolic; Bone Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Ole L Svendsen, M.D

  Bispebjerg Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Tomas, m Christensen, M.D

CONTACT

+45 35316661; tc12@bbh.hosp.dk

Study Design

• Study Type: observational
• Observational Model: DEFINED POPULATION
• Time Perspective: OTHER
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: September 8, 2005
• First Posted: September 12, 2005
• Study Start: May 1, 2005
• Study Completion: April 1, 2008
• Last Updated: December 8, 2005

Record last verified: 2005-09

Locations

DK (1)