MMR and Varicella Vaccine in Premature Infants

NCT00156559 | Completed

• 2 other identifiers: DMID 03-140N01-AI-25460
• Study Type: observational
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

This research is designed to address the question, "Does the relative deficit in vaccine immunogenicity in extremely premature infants persist beyond the first 6 months of life?" We propose to measure the immunogenicity of varicella and mumps-measles-rubella vaccines in relatively healthy, 12-to-15 month-old children born at \<29 weeks gestation, when compared to full-term infants, as measured by the relevant viral serologies.

Conditions

Chickenpox; Rubella; Rubeola; Mumps

Keywords

immunization; vaccine; low birth weight infant; premature infant

Eligibility Criteria

• Age: 12 Months - 16 Months
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Premature infant \< 29 weeks' gestation at birth or term infant \>/= 37 weeks' gestation at birth.
• Postnatal age \< 16 months, 0 days.
• Has not yet received MMR or varicella vaccines. (There are no restrictions on the administration of other vaccines at the time of MMR/varicella vaccination.)
• Parental permission.
• Agreement of primary care pediatrician/ health care provider.
• Receives primary pediatric care within an approximate 25-mile radius of the University of Rochester.
• Healthy status at enrollment.

You may not qualify if:

• Known immunodeficiency.
• Systemic corticosteroid therapy at the time of MMR/varicella vaccination.
• Requiring oxygen therapy.
• Any condition determined by the investigator that would interfere with the evaluation of the vaccine or be a potential health risk to the subject.

Sponsors & Collaborators

• University of Rochester: lead

Study Sites (1)

University of Rochester

Rochester, New York, 14642, United States

Location

Related Publications (1)

• D'Angio CT, Boohene PA, Mowrer A, Audet S, Menegus MA, Schmid DS, Beeler JA. Measles-mumps-rubella and varicella vaccine responses in extremely preterm infants. Pediatrics. 2007 Mar;119(3):e574-9. doi: 10.1542/peds.2006-2241.

  PMID: 17332177 RESULT

MeSH Terms

Conditions

Chickenpox; Rubella; Measles; Mumps; Premature Birth

Condition Hierarchy (Ancestors)

Varicella Zoster Virus Infection; Herpesviridae Infections; DNA Virus Infections; Virus Diseases; Infections; Rubivirus Infections; Togaviridae Infections; RNA Virus Infections; Morbillivirus Infections; Paramyxoviridae Infections; Mononegavirales Infections; Rubulavirus Infections; Parotitis; Parotid Diseases; Salivary Gland Diseases; Mouth Diseases; Stomatognathic Diseases; Obstetric Labor, Premature; Obstetric Labor Complications; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases

Study Officials

• Carl T. D'Angio, MD

  University of Rochester

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 8, 2005
• First Posted: September 12, 2005
• Study Start: January 1, 2004
• Study Completion: May 1, 2005
• Last Updated: September 17, 2015

Record last verified: 2015-09

Locations

US (1)