Skeletal Muscle Dysfunction in Heart Failure
Training and Congestive Heart Failure
3 other identifiers
interventional
45
1 country
2
Brief Summary
Patients suffering from congestive heart failure report reduced exercise capacity. This skeletal muscle dysfunction is also detectable when using small muscle groups which should not put any demand on the heart. We hypothesize that congestive heart failure has systemic effects that causes the skeletal muscle dysfunction.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2005
CompletedFirst Submitted
Initial submission to the registry
September 8, 2005
CompletedFirst Posted
Study publicly available on registry
September 12, 2005
CompletedSeptember 12, 2005
September 1, 2005
September 8, 2005
September 8, 2005
Conditions
Interventions
Eligibility Criteria
You may qualify if:
- Coronary Heart Failure
- Ejection fraction \<35%
- NYHA 2-3
- Spirometry FEV1 \> 80%
You may not qualify if:
- Cardiomyopathy
- Transplantation candidate
- Active malignancy
- Restraining skeletal-muscular disease
- Claudication in legs
- Hospitalized last 30 days due to acute ischemic episode
- Organized training last 4 months
- Smoking on daily basis last 4 months
- Creatinin \< 150microliters/liter
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Ullevaal University Hospitallead
- Norwegian Health Associationcollaborator
- Norwegian School of Sport Sciencescollaborator
- The Research Council of Norwaycollaborator
- University of Oslocollaborator
Study Sites (2)
Institute for Experimental Medical Research
Oslo, Oslo County, 0407, Norway
Norwegian School of Sport Sciences
Oslo, Oslo County, 0806, Norway
Related Publications (1)
Munkvik M, Rehn TA, Slettalokken G, Hasic A, Hallen J, Sjaastad I, Sejersted OM, Lunde PK. Training effects on skeletal muscle calcium handling in human chronic heart failure. Med Sci Sports Exerc. 2010 May;42(5):847-55. doi: 10.1249/MSS.0b013e3181c29ec1.
PMID: 19996998DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Ole M Sejersted, Professor
Institute for Experimental Medical Research, Ullevaal University Hospital
- STUDY DIRECTOR
Per Kristian B Lunde, Post Doc
Institute for Experimental Medical Research, Ullevaal University Hospital
- STUDY DIRECTOR
Ivar Sjaastad, Post Doc
Institute for Experimental Medical Research, Ullevaal University Hospital
- STUDY CHAIR
Jostein Hallen, Professor
Norwegian School of Sport Sciences
- PRINCIPAL INVESTIGATOR
Morten Munkvik, Ph.D student
Institute for Experimental Medical Research, Ullevaal University Hospital
- PRINCIPAL INVESTIGATOR
Tommy A Rehn, Vit.ass.
Institute for Experimental Medical Research, Ullevaal University Hospital
- PRINCIPAL INVESTIGATOR
Gunnar S Petersen, Ph.D student
Norwegian School of Sport Sciences
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Purpose
- ECT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
September 8, 2005
First Posted
September 12, 2005
Study Start
March 1, 2005
Last Updated
September 12, 2005
Record last verified: 2005-09