NCT00143650

Brief Summary

The study is focussed on two main questions:

  1. 1.The importance of dampness of the building and home dust as a factor of the subjects= responses.
  2. 2.Can measures used in KLINIR predict the subjects' responses to the dust?
  3. 3.Does dust in general cause inflammatory/body perceptions through e.g. an irritation symptoms index.
  4. 4.Does the dust include effective odorants which affects an IAQ index?
  5. 5.Does dampness increase the content of organic or inorganic compounds e.g. of microbial origin that causes the dust to be more reactive? (Differences between the two types of dust)
  6. 6.Is the sensitivity of the subjects explaining the responses to exposures in a, b, or c? (Subject group and sensitivity index)

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
27

participants targeted

Target at P25-P50 for phase_1

Timeline
Completed

Started Jan 2001

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2001

Completed
1.7 years until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2002

Completed
3 years until next milestone

First Submitted

Initial submission to the registry

September 1, 2005

Completed
1 day until next milestone

First Posted

Study publicly available on registry

September 2, 2005

Completed
Last Updated

January 17, 2007

Status Verified

January 1, 2005

First QC Date

September 1, 2005

Last Update Submit

January 16, 2007

Conditions

Upper Airway, Irritation Inflammation, Discomfort

Keywords

Upper airway, irritation inflammation, discomfort, house dust, damp buildings, climate chamber, humans

Outcome Measures

Primary Outcomes (1)

  • Acoustic rhinometry, general symptoms, inflammation

Interventions

House dustBEHAVIORAL

Eligibility Criteria

Age18 Years - 64 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • All in local area, nasal histamine responsive, grass allergic, from study KLINIR.

You may not qualify if:

  • Pregnancy, house dust allergy, hyper-responding air ways, disease, disabled

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

The Air Pollution Unit, Department of Environmental and Occupational Medicine, Institute of Public Health, The University of Aarhus

Aarhus, DK-8000,, Denmark

Location

MeSH Terms

Interventions

Dust

Intervention Hierarchy (Ancestors)

Particulate MatterComplex Mixtures

Study Officials

  • Lars Mølhave,, DMSc, Ph.D.

    The Air Pollution Unit, Department of Environmental and Occupational Medicine, Institute of Public Health, The University of Aarhus

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 1
Allocation
NON RANDOMIZED
Masking
DOUBLE
Purpose
PREVENTION
Intervention Model
CROSSOVER
Sponsor Type
OTHER

Study Record Dates

First Submitted

September 1, 2005

First Posted

September 2, 2005

Study Start

January 1, 2001

Study Completion

September 1, 2002

Last Updated

January 17, 2007

Record last verified: 2005-01

Locations

DK(1)