Amlodipine vs Nitrates Study in Patients With Chronic Stable Angina
ANISSA
Open Label Study Comparing Amlodipine vs Long-acting Nitrates in Patients With Chronic Stable Angina.
1 other identifier
interventional
200
1 country
12
Brief Summary
The objective of study is to compare the anti-ischemic efficacy and safety profiles of once daily amlodipine or isosorbide-5-mononitrate in the treatment of stable asymptomatic and symptomatic myocardial ischemia
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_4
Started Apr 2001
Longer than P75 for phase_4
12 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2001
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2005
CompletedFirst Submitted
Initial submission to the registry
August 31, 2005
CompletedFirst Posted
Study publicly available on registry
September 2, 2005
CompletedJanuary 28, 2021
January 1, 2021
August 31, 2005
January 26, 2021
Conditions
Outcome Measures
Primary Outcomes (1)
Evaluate the time to 1mm ST depression
Secondary Outcomes (1)
The number of patients experiencing angina attacks The frequency of hospitalizations due to angina attacks Time to onset of 1mm ST segment depression Total external workload performed Safety
Interventions
Eligibility Criteria
You may qualify if:
- Outpatients \> =18 years of age with diagnosed clinically stable angina pectoris
You may not qualify if:
- Patients with congestive heart failure, clinically significant cardiovascular disease, standing systolic blood pressure of less than 100mmHg, concomitant anti-anginal therapies similar to sublingual NTG
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (12)
Pfizer Investigational Site
Athens, Attica, 11527, Greece
Pfizer Investigational Site
Athens, 123 51, Greece
Pfizer Investigational Site
Athens, Greece
Pfizer Investigational Site
Holargos/Athens, 11525, Greece
Pfizer Investigational Site
Loannina, 45500, Greece
Pfizer Investigational Site
N. Ionia, 143 88, Greece
Pfizer Investigational Site
Pátrai, 26335, Greece
Pfizer Investigational Site
Rio, Patra, 26499, Greece
Pfizer Investigational Site
Thessaloniki, 546 36, Greece
Pfizer Investigational Site
Thessaloniki, 54639, Greece
Pfizer Investigational Site
Voula/Athens, Greece
Pfizer Investigational Site
Zakynthos, 29100, Greece
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Pfizer CT.gov Call Center
Pfizer
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 31, 2005
First Posted
September 2, 2005
Study Start
April 1, 2001
Study Completion
January 1, 2005
Last Updated
January 28, 2021
Record last verified: 2021-01