Bone Status and Insulin Resistance in Hirsutism

NCT00143052 | Completed

• 1 other identifier: 003
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate how the bones of hirsute women are different from bones of healthy women. The change in hormone content in the blood will also be investigated. The study can be used to evaluate whether it will be relevant to bone scan all newly referred hirsute women. Hirsute women are often over-weight and often have an increased amount of the male sex hormone in their blood. Their blood tests often show changes reminding of the ones seen in diabetic patients. All hirsute women referred to the department will undergo an investigation revealing the reason for the increased hair growth. The investigation includes clinical investigation (height, weight and degree of hair growth), blood tests (for hormone status and bone status analysis) and bone scanning of the abdomen (body composition). The trial includes a group of 50 strongly hairy women and a control group of 50 healthy women with normal hair growth. They are matched by body weight, since weight has great importance for the bone mineral content and thereby for osteoporosis in the long run.

Conditions

Hirsutism

Keywords

Hirsutism; Bone status; Androgens; insulin

Eligibility Criteria

• Age: 20 Years - 46 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

Study Population

hirsute patients vs. controls

You may qualify if:

• Hirsute subjects:
• Belonging to group 1 or 2.
• Age: 20-46
• Hirsute score: \>7
• Written informed consent
• Control group:
• Age: 20-46
• Hirsute score: 0 (without razing)
• Regular menses
• Written informed consent

You may not qualify if:

• Previous cosmetic treatment for hirsutism.
• Use of contraceptive pill (within the past 6 months)
• Systemic steroid treatment \> 6 weeks (ever)
• Age above 46 years/post menopause (increased FSH)
• Recognized diabetes mellitus or other endocrine disease
• Eating disorder
• Serious, treatment demanding disease

Sponsors & Collaborators

• Odense University Hospital: lead

Study Sites (1)

Diabetes Research Center

Odense, Funen, 5000, Denmark

Location

MeSH Terms

Conditions

Hirsutism; Insulin Resistance

Condition Hierarchy (Ancestors)

Hair Diseases; Skin Diseases; Skin and Connective Tissue Diseases; Virilism; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Dorte Glintborg, MD

  Odense University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: September 1, 2005
• First Posted: September 2, 2005
• Study Start: January 1, 2002
• Primary Completion: January 1, 2007
• Study Completion: January 1, 2007
• Last Updated: June 24, 2008

Record last verified: 2008-06

Locations

DK (1)