NCT00140959

Brief Summary

A study to evaluate the effects of combination losartan versus combination atenolol in patients with ambulatory systolic hypertension.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
120

participants targeted

Target at P50-P75 for phase_4 hypertension

Timeline
Completed

Started Feb 2003

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 2003

Completed
1.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2004

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2004

Completed
1.2 years until next milestone

First Submitted

Initial submission to the registry

August 31, 2005

Completed
1 day until next milestone

First Posted

Study publicly available on registry

September 1, 2005

Completed
Last Updated

August 15, 2024

Status Verified

February 1, 2022

Enrollment Period

1.4 years

First QC Date

August 31, 2005

Last Update Submit

August 13, 2024

Conditions

Hypertension

Outcome Measures

Primary Outcomes (1)

  • Mean daytime ambulatory systolic blood pressure

Secondary Outcomes (4)

  • Ambulatory BP

  • Pulse pressure

  • Trough sitting BP

  • Percentage of patients who reach goal ambulatory systolic BP

Interventions

MK0954, losartan potassium/Duration of Treatment: 18 weeksDRUG
Comparator: losartan, HCTZ, amlodipine, atenolol/Duration of Treatment: 18 weeksDRUG

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Males or females at least 18 years of age who have ambulatory systolic hypertension.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (1)

  • Lacourciere Y, Poirier L, Lefebvre J. Expedited blood pressure control with initial angiotensin II antagonist/diuretic therapy compared with stepped-care therapy in patients with ambulatory systolic hypertension. Can J Cardiol. 2007 Apr;23(5):377-82. doi: 10.1016/s0828-282x(07)70771-7.

    PMID: 17440643BACKGROUND

MeSH Terms

Conditions

Hypertension

Interventions

LosartanDuration of TherapyHydrochlorothiazideAmlodipineAtenolol

Condition Hierarchy (Ancestors)

Vascular DiseasesCardiovascular Diseases

Intervention Hierarchy (Ancestors)

Biphenyl CompoundsBenzene DerivativesHydrocarbons, AromaticHydrocarbons, CyclicHydrocarbonsOrganic ChemicalsImidazolesAzolesHeterocyclic Compounds, 1-RingHeterocyclic CompoundsTetrazolesPatient CareTherapeuticsHealth ServicesHealth Care Facilities Workforce and ServicesChlorothiazideBenzothiadiazinesSulfonamidesSulfonesSulfur CompoundsThiazidesHeterocyclic Compounds, 2-RingHeterocyclic Compounds, Fused-RingDihydropyridinesPyridinesPhenoxypropanolaminesPropanolaminesAmino AlcoholsAlcoholsPropanolsAmines

Study Officials

  • Medical Monitor

    Merck Sharp & Dohme LLC

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 31, 2005

First Posted

September 1, 2005

Study Start

February 1, 2003

Primary Completion

June 30, 2004

Study Completion

June 30, 2004

Last Updated

August 15, 2024

Record last verified: 2022-02