Assessing and Monitoring the Efficacy of Sulfadoxine/ Pyrimethamine (SP) and the Combination of SP Plus Artesunate for Uncomplicated Malaria Infections Among Children
Sponsor study identifier
Secondary identifiers
interventional
390
1 country
3
Study Start
January 2000
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
January 2008
Actual (reported)Study Completion
January 2008
Actual (reported)This is an ongoing monitoring activity of efficacy of sulfadoxine-pyrimethamine (SP), which is the current national treatment of choice for uncomplicated malaria in Tanzania, and a combination of SP and artesunate among children \< 5 years in 3 sites in rural Tanzania. Protocol was amended in 2004 to (1) include lumefantrine+artemether, the newly identified first-line treatment for malaria to be introduced into Tanzania in 2006; (2) on a limited basis, include adult patients; (3) extend follow-up to 28 days; (4) investigate whether treated bednets would reduce confounding by reinfection
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
January 2008
Actual (reported)Click on a node to explore related trials.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 2000
Date type not reportedThis date has not been verified as actual or estimated.
August 30, 2005
Actual (reported)September 1, 2005
Actual (reported)January 2008
Actual (reported)January 2008
Actual (reported)Clinical and parasitologic failure rate
These entries preserve how the registry describes the intervention. Their treatment roles are shown separately from molecular identities.
Grouped treatment entry
sulfadoxine-pyrimethamine plus artesunate
The registry names several treatments. This does not confirm that participants received them together or that they form a single product.
View registry recordPartially structured registry wording
lumefantrine plus artemether
Part of this registry label remains unresolved and is preserved as written. Recognized names are text references, not confirmed ingredients. Composition, doses and actual exposure are not established.
Names joined in the label
1 recognized name reference in the wording; 1 unresolved part.
Ngere Ngere Health Center
Ngerengere, Morogoro Rural, Tanzania
Ikwiriri Health Center
Ikwiriri, Rufiji, Tanzania
Lupiro Health Center
Lupiro, Ulanga, Tanzania
Peter B Bloland, DVM, MPVM
Centers for Disease Control and Prevention
Salim Abdulla, MD, PhD
Ifakara Health Research and Development Centre
John R MacArthur, MD, MPH
Centers for Disease Control and Prevention
390 participants (actual enrollment reported by the registry).
First Submitted
August 30, 2005
First Posted
September 1, 2005
Study Start
January 2000
Date type not reportedThis date has not been verified as actual or estimated.
Assessing the Efficacy of Four Drug Combinations as the Next First-line Therapy for Uncomplicated Malaria in Malawi
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Primary Completion
January 2008
Actual (reported)Study Completion
January 2008
Actual (reported)Last Updated
September 11, 2012
Record last verified: 2012-09
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Source: ClinicalTrials.gov.
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