NCT00137371

Brief Summary

This protocol is designed to study the effect and safety of 2 low-dose regimens of conjugated estrogen cream (PVC) given vaginally in postmenopausal women with atrophic vaginitis.

Trial Health

90
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
480

participants targeted

Target at P50-P75 for phase_3

Timeline
Completed

Started Aug 2005

Geographic Reach
2 countries

49 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2005

Completed
24 days until next milestone

First Submitted

Initial submission to the registry

August 25, 2005

Completed
4 days until next milestone

First Posted

Study publicly available on registry

August 29, 2005

Completed
2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2007

Completed
Last Updated

December 10, 2007

Status Verified

December 1, 2007

First QC Date

August 25, 2005

Last Update Submit

December 7, 2007

Conditions

Keywords

PostmenopauseVaginitis

Outcome Measures

Primary Outcomes (1)

  • To evaluate the efficacy of 2 low dose regimens of conjugated estrogen in the treatment of atrophic vaginitis from baseline to 12 weeks.

Secondary Outcomes (1)

  • To evaluate change from baseline in the percentage of superficial cells, symptom relief, the effect of both regimens on endometrial stimulation and genital health.

Interventions

Eligibility Criteria

Age45 Years - 80 Years
Sexfemale
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Generally healthy postmenopausal women with symptoms of atrophic vaginitis including vaginal dryness, vaginal itching, vaginal burning, and/or painful intercourse.
  • The subject must have a clinical diagnosis of atrophic vaginitis and an intact uterus.

You may not qualify if:

  • Women who do not have a clinical diagnosis of atrophic vaginitis.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (49)

Unknown Facility

Tucson, Arizona, 85715, United States

Location

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Encinitas, California, 92024, United States

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San Diego, California, 92108, United States

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Torrance, California, 90502, United States

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Aurora, Colorado, 80010, United States

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Brooksville, Florida, 34613, United States

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Miami, Florida, 33186, United States

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St. Petersburg, Florida, 33709, United States

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Tampa, Florida, 33066, United States

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West Palm Beach, Florida, 33407, United States

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Atlanta, Georgia, 30328, United States

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Augusta, Georgia, 30901, United States

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Chicago, Illinois, 60612, United States

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Metairie, Louisiana, 70006, United States

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Troy, Michigan, 48084, United States

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St Louis, Missouri, 63141, United States

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Omaha, Nebraska, 68134, United States

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New Brunswick, New Jersey, 08901, United States

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Chapel Hill, North Carolina, 27514, United States

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Winston-Salem, North Carolina, 27103, United States

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Oklahoma City, Oklahoma, 73112, United States

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Danville, Pennsylvania, 17822-2920, United States

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Philadelphia, Pennsylvania, 19104, United States

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Pittsburgh, Pennsylvania, 15206, United States

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Carrollton, Texas, 75006, United States

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Carrollton, Texas, 75010, United States

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Colleyville, Texas, 76034, United States

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Dallas, Texas, 75246, United States

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Houston, Texas, 77030, United States

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Plano, Texas, 75093, United States

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Charlottesville, Virginia, 22903, United States

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Norfolk, Virginia, 23502, United States

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Calgary, Alberta, T2N 4L7, Canada

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Coquitlam, British Columbia, V3K 3V9, Canada

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Langley, British Columbia, V3H 4H9, Canada

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Winnipeg, Manitoba, R3A 1M3, Canada

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Winnipeg, Manitoba, R3A 1R9, Canada

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Kingston, Ontario, K7L 2V7, Canada

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Ottawa, Ontario, K1H 7W9, Canada

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Toronto, Ontario, M5C 1R6, Canada

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Toronto, Ontario, M5G 1Z5, Canada

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Toronto, Ontario, M9W 4L6, Canada

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Montréal, Quebec, H1T 1P6, Canada

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Montréal, Quebec, H2X 1N8, Canada

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Montreal, Quebec, H3M 3A9, Canada

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Pointe-Claire, Quebec, H9R 4S3, Canada

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Québec, Quebec, G1L 3L5, Canada

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Shawinigan, Quebec, G9N 2H6, Canada

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Sherbrooke, Quebec, J1H 5N4, Canada

Location

MeSH Terms

Conditions

Atrophic VaginitisAtrophyVaginitis

Interventions

Polyvinyl Chloride

Condition Hierarchy (Ancestors)

Vaginal DiseasesGenital Diseases, FemaleFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesGenital DiseasesPathological Conditions, AnatomicalPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

PolyvinylsVinyl CompoundsAlkenesHydrocarbons, AcyclicHydrocarbonsOrganic ChemicalsPlasticsPolymersMacromolecular SubstancesElastomersBiomedical and Dental MaterialsManufactured MaterialsTechnology, Industry, and Agriculture

Study Officials

  • Medical Monitor

    Wyeth is now a wholly owned subsidiary of Pfizer

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
DOUBLE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

August 25, 2005

First Posted

August 29, 2005

Study Start

August 1, 2005

Study Completion

September 1, 2007

Last Updated

December 10, 2007

Record last verified: 2007-12

Locations