Factors Predicting Efficacy of Allergen Injection Immunotherapy for Grass Pollen Hayfever

You may not qualify if:

• FEV1 \< 70% of predicted value
• A clinical history of symptomatic seasonal allergic rhinitis and/or asthma due to tree pollen or weed pollen adjacent to the start of - and potentially overlapping - the grass pollen season
• A clinical history of significant symptomatic perennial allergic rhinitis and/or asthma caused by an allergen to which the subject is regularly exposed
• A clinical history of significant recurrent acute sinusitis (defined as 2 episodes per year for the last two years all of which required antibiotic treatment) or chronic sinusitis
• History of emergency visit or admission for asthma in the previous 12 months
• Use of an investigational drug within 30 days prior to screening
• Previous treatment by immunotherapy with grass pollen allergen or any other allergen within the previous 5 years
• History of anaphylaxis, including anaphylactic food allergy, bee venom anaphylaxis, exercise anaphylaxis or drug induced anaphylaxis
• History of angioedema
• Any of the following underlying conditions known or suspected to be present:
• Cystic fibrosis
• Malignancy
• Insulin-dependent diabetes
• Malabsorption or malnutrition
• Renal or hepatic insufficiency
• +8 more criteria