NCT00134498

Brief Summary

The Torcetrapib project was terminated on December 2, 2006 due to safety findings. To assess the safety and efficacy of the fixed combination torcetrapib/atorvastatin in subjects with Fredrickson Type IV Hypertriglyceridemia.

Trial Health

90
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
160

participants targeted

Target at P25-P50 for phase_3

Timeline
Completed

Started Feb 2005

Geographic Reach
2 countries

44 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 2005

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

August 22, 2005

Completed
2 days until next milestone

First Posted

Study publicly available on registry

August 24, 2005

Completed
1.2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2006

Completed
Last Updated

November 16, 2007

Status Verified

March 1, 2007

First QC Date

August 22, 2005

Last Update Submit

November 15, 2007

Conditions

Outcome Measures

Primary Outcomes (1)

  • Change in HDL-C and non-HDL-C levels

Secondary Outcomes (1)

  • Changes in levels of other lipid and biomarkers.

Interventions

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Diagnosis of Fredrickson Type IV Hypertriglyceridemia

You may not qualify if:

  • Women who are pregnant or lactating, or planning to become pregnant.
  • Subjects with a clinically indicated need for statin (HMG-CoA reductase inhibitor) therapy other than atorvastatin or other concomitant therapy with known lipid altering effects on LDL-C and HDL-C including fibrates and nicotinic acid
  • Subjects taking any drugs known to be associated with an increased risk of myositis in combination with HMG-CoA reductase inhibitors
  • Subjects with any other medical condition or laboratory abnormality which could affect subject safety, preclude evaluation of response, or render unlikely that the subject would complete the study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (44)

Pfizer Investigational Site

Anaheim, California, United States

Location

Pfizer Investigational Site

Huntington Beach, California, United States

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Pfizer Investigational Site

Los Angeles, California, United States

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Pfizer Investigational Site

Orange, California, United States

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Pfizer Investigational Site

Orangevale, California, United States

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Pfizer Investigational Site

Pacific Palisades, California, United States

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Pfizer Investigational Site

Studio City, California, United States

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Pfizer Investigational Site

Tustin, California, United States

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Pfizer Investigational Site

Walnut Creek, California, United States

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Pfizer Investigational Site

Farmington, Connecticut, United States

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Pfizer Investigational Site

Washington D.C., District of Columbia, United States

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Pfizer Investigational Site

Hollywood, Florida, United States

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Pfizer Investigational Site

Longwood, Florida, United States

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Pfizer Investigational Site

West Palm Beach, Florida, United States

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Pfizer Investigational Site

Tripler AMC, Hawaii, United States

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Pfizer Investigational Site

Chicago, Illinois, United States

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Pfizer Investigational Site

Indianapolis, Indiana, United States

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Pfizer Investigational Site

Overland Park, Kansas, United States

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Pfizer Investigational Site

Baton Rouge, Louisiana, United States

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Pfizer Investigational Site

Scarborough, Maine, United States

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Pfizer Investigational Site

Bethesda, Maryland, United States

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Pfizer Investigational Site

Ann Arbor, Michigan, United States

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Pfizer Investigational Site

Canton, Michigan, United States

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Pfizer Investigational Site

Portage, Michigan, United States

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Pfizer Investigational Site

Richland, Michigan, United States

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Pfizer Investigational Site

Saint Cloud, Minnesota, United States

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Pfizer Investigational Site

Olive Branch, Mississippi, United States

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Pfizer Investigational Site

Jefferson City, Missouri, United States

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Pfizer Investigational Site

St Louis, Missouri, United States

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Pfizer Investigational Site

Las Vegas, Nevada, United States

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Pfizer Investigational Site

Rochester, New York, United States

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Pfizer Investigational Site

Syracuse, New York, United States

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Pfizer Investigational Site

West Seneca, New York, United States

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Pfizer Investigational Site

Statesville, North Carolina, United States

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Pfizer Investigational Site

Sellersville, Pennsylvania, United States

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Pfizer Investigational Site

Warwick, Rhode Island, United States

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Pfizer Investigational Site

San Antonio, Texas, United States

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Pfizer Investigational Site

Richmond, Virginia, United States

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Pfizer Investigational Site

Madison, Wisconsin, United States

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Pfizer Investigational Site

Halifax, Nova Scotia, Canada

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Pfizer Investigational Site

London, Ontario, Canada

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Pfizer Investigational Site

Chicoutimi, Quebec, Canada

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Pfizer Investigational Site

Montreal, Quebec, Canada

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Pfizer Investigational Site

Ste-Foy, Quebec, Canada

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Related Links

MeSH Terms

Conditions

HypertriglyceridemiaHyperlipoproteinemia Type IV

Interventions

torcetrapibAtorvastatin

Condition Hierarchy (Ancestors)

HyperlipidemiasDyslipidemiasLipid Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesLipid Metabolism, Inborn ErrorsMetabolism, Inborn ErrorsGenetic Diseases, InbornCongenital, Hereditary, and Neonatal Diseases and AbnormalitiesHyperlipoproteinemias

Intervention Hierarchy (Ancestors)

PyrrolesAzolesHeterocyclic Compounds, 1-RingHeterocyclic CompoundsHeptanoic AcidsFatty AcidsLipids

Study Officials

  • Pfizer CT.gov Call Center

    Pfizer

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
DOUBLE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

August 22, 2005

First Posted

August 24, 2005

Study Start

February 1, 2005

Study Completion

November 1, 2006

Last Updated

November 16, 2007

Record last verified: 2007-03

Locations