NCT00130221|CompletedPhase 1
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Sponsor study identifier
interventional
208
1 country
1
Study Start
June 2005
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
June 2006
Actual (reported)Study Completion
July 26, 2006
Actual (reported)Patients in the intensive care unit are at risk for many infections because the severity of illness and the procedures necessary to care for them. This study is designed to look at a change in bathing procedure as a method to reduce infections. Currently, patients at John H. Stroger Hospital are cleansed with soap and water. However, preliminary data from a previous study at Rush University Medical Center showed that a chlorhexidine (CHG)-impregnated cloth (2% CHG Antiseptic Cloth system, Sage Products, Inc.) decreased skin bacteria and may lessen bacteria in the blood stream. The 2% CHG Antiseptic Cloth system is a non-irritating, no-rinse, cleansing and moisturizing product that contains 2% chlorhexidine gluconate. The goal of this proposed study is to further evaluate the effectiveness of the 2% CHG Antiseptic Cloth system compared with soap and water in cleansing the skin and preventing bacteria from entering the bloodstream.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 26, 2006
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 2005
Date type not reportedThis date has not been verified as actual or estimated.
August 12, 2005
Actual (reported)August 15, 2005
Actual (reported)June 2006
Actual (reported)July 26, 2006
Actual (reported)Clinical: Primary blood stream infections and culture negative sepsis
Weekly culture of central line insertion sites
Six Months
Microbiologic: Skin colonization from environment and endotracheal secretions
Weekly skin cultures
Six Months
Clinical: Laboratory confirmed blood stream infections
Six months
daily skin cleansing with no-rinse, 2% CHG-impregnated cloths (Sage)
bathing daily with bar soap (Dial Corp., Scottsdale, AZ) warm water, and cotton washcloths
bathed daily with bar soap (Dial Corp., Scottsdale, AZ), warm water, and cotton washcloths.
John H. Stroger Hospital of Cook County
Chicago, Illinois, 60612, United States
Appelgren P, Hellstrom I, Weitzberg E, Soderlund V, Bindslev L, Ransjo U. Risk factors for nosocomial intensive care infection: a long-term prospective analysis. Acta Anaesthesiol Scand. 2001 Jul;45(6):710-9. doi: 10.1034/j.1399-6576.2001.045006710.x.
Beezhold DW, Slaughter S, Hayden MK, Matushek M, Nathan C, Trenholme GM, Weinstein RA. Skin colonization with vancomycin-resistant enterococci among hospitalized patients with bacteremia. Clin Infect Dis. 1997 Apr;24(4):704-6. doi: 10.1093/clind/24.4.704.
Robert A Weinstein, MD
John H. Stroger Hospital of Cook County
208 participants (actual enrollment reported by the registry).
First Submitted
August 12, 2005
First Posted
August 15, 2005
Study Start
June 2005
Date type not reportedThis date has not been verified as actual or estimated.
E. Coli for Prevention of Catheter UTI in SCI Patients
Nosocomial infections
Six months
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
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Cohen J, Cristofaro P, Carlet J, Opal S. New method of classifying infections in critically ill patients. Crit Care Med. 2004 Jul;32(7):1510-26. doi: 10.1097/01.ccm.0000129973.13104.2d.
Mermel LA, Farr BM, Sherertz RJ, Raad II, O'Grady N, Harris JS, Craven DE; Infectious Diseases Society of America; American College of Critical Care Medicine; Society for Healthcare Epidemiology of America. Guidelines for the management of intravascular catheter-related infections. Clin Infect Dis. 2001 May 1;32(9):1249-72. doi: 10.1086/320001. Epub 2001 Apr 3. No abstract available.
O'grady NP, Alexander M, Dellinger EP, Gerberding JL, Heard SO, Maki DG, Masur H, McCormick RD, Mermel LA, Pearson ML, Raad II, Randolph A, Weinstein RA; Healthcare Infection Control Practices Advisory Committee. Guidelines for the prevention of intravascular catheter-related infections. Am J Infect Control. 2002 Dec;30(8):476-89. doi: 10.1067/mic.2002.129427.
Shorr AF, Humphreys CW, Helman DL. New choices for central venous catheters: potential financial implications. Chest. 2003 Jul;124(1):275-84.
Bleasdale SC, Trick WE, Gonzalez IM, Lyles RD, Hayden MK, Weinstein RA. Effectiveness of chlorhexidine bathing to reduce catheter-associated bloodstream infections in medical intensive care unit patients. Arch Intern Med. 2007 Oct 22;167(19):2073-9. doi: 10.1001/archinte.167.19.2073.
Primary Completion
June 2006
Actual (reported)Study Completion
July 26, 2006
Actual (reported)Last Updated
June 18, 2023
Record last verified: 2023-06
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