Adherence to Guidelines for Antibiotic Use in Respiratory Infections at Hospitals
Prevention of Antimicrobial Resistance in Hospitals: Promoting Appropriate Use of Antibiotics in Hospital Departments of Internal and Pulmonary Medicine
2 other identifiers
interventional
2,000
1 country
7
Brief Summary
The purpose of this study is to test a strategy to improve the quality of antibiotic use in lower respiratory tract infections (LRTIs) at hospitals. Therefore, a multifaceted intervention strategy is compared to a control strategy and the effectiveness and feasibility of the intervention is assessed.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Sep 2002
Typical duration for not_applicable
7 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2002
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2005
CompletedFirst Submitted
Initial submission to the registry
August 11, 2005
CompletedFirst Posted
Study publicly available on registry
August 12, 2005
CompletedSeptember 27, 2005
August 1, 2002
August 11, 2005
September 26, 2005
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
adherence to key quality indicators for antibiotic use in lower respiratory tract infections (indicators were developed from current [inter]national guideline recommendations and a systematic review of the literature)
Secondary Outcomes (6)
cost
process evaluation: how well was the intervention performed
length of hospital stay
in-hospital mortality
Intensive Care Unit (ICU)-transfer
- +1 more secondary outcomes
Interventions
Eligibility Criteria
You may qualify if:
- Patients admitted to a respiratory care or internal medicine ward with community-acquired pneumonia or acute exacerbation of chronic bronchitis or chronic obstructive pulmonary disease (COPD)
You may not qualify if:
- Recent (\< 30 days) admission for LRTI
- Patients with underlying immunodeficiency (HIV infection, neutropenia, treatment with immunomodulating drugs, active hematological malignancies, anatomical or functional asplenia and hypogammaglobulinemia)
- Patients already on treatment with antibiotics for another culture proven infection at the time of admission
- Patients from nursing homes
- Patients who had been transferred to another hospital or ICU and patients who had died within 24 hours of admission
- Patients with very poor prognosis (life expectancy \< 2 weeks on admission).
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (7)
Gelre Ziekenhuizen
Apeldoorn, Netherlands
Deventer Ziekenhuis
Deventer, Netherlands
Ziekenhuis Gelderse Vallei
Ede, Netherlands
Bernhoven Ziekenhuis
Oss, Netherlands
Bernhoven Ziekenhuis
Veghel, Netherlands
Maxima Medisch Centrum
Veldhoven, Netherlands
Vie Curi Medisch Centrum
Venlo, Netherlands
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Marlies E Hulscher, MSc, PhD
Centre for Quality of Care Research, Radboud University Nijmegen Medical Centre
- STUDY DIRECTOR
Richard P Grol, MSc, PhD
Centre for Quality of Care Research, Radboud University Nijmegen Medical Centre
- STUDY DIRECTOR
Jos WM van der Meer, MD, PhD
Department of General Internal Medicine, Radboud University Nijmegen Medical Centre
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- ECT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
August 11, 2005
First Posted
August 12, 2005
Study Start
September 1, 2002
Study Completion
April 1, 2005
Last Updated
September 27, 2005
Record last verified: 2002-08