NCT00129324

Brief Summary

The goal of the HOME Study is to quantify the impact of low-level fetal and early childhood exposures to environmental toxicants including lead, mercury, and other metals, pesticides, polychlorinated biphenyls (PCBs), persistent organic pollutants (PBDEs/PFCs), phthalates, phenols, environmental tobacco smoke, and alcohol on child development, neurobehavior, health, and growth. The HOME Study will also evaluate meconium as a biomarker for fetal exposure and test the effectiveness of home repairs to control lead hazards and injuries in early childhood.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
468

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Mar 2003

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2003

Completed
2.4 years until next milestone

First Submitted

Initial submission to the registry

August 10, 2005

Completed
1 day until next milestone

First Posted

Study publicly available on registry

August 11, 2005

Completed
13 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2018

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2018

Completed
Last Updated

March 6, 2020

Status Verified

March 1, 2020

Enrollment Period

15.4 years

First QC Date

August 10, 2005

Last Update Submit

March 5, 2020

Conditions

Environmental ExposuresChild DevelopmentLead and Injury Reduction

Keywords

HOMEEnvironmental ExposureNeurobehaviorChild DevelopmentLead ExposureChild InjuryAdolescenceAdiposityNeuroimaging

Outcome Measures

Primary Outcomes (3)

  • Lead reduction intervention, blood lead concentrations & neurobehavioral outcomes

    Testing the efficacy of lead reduction controls in the homes of participants. Examining the effects of low level blood lead concentration on child development and neurobehavior. Measures of blood lead concentration were taken from mothers prenatally at approximately 16 and 26 weeks gestation, from cord blood at birth, and annually from participating children from 1 - 10 years of age.

    16wk & 26wk gestation, birth, annually at 1y-12y

  • Exposure to environmental chemicals and their effects on child health, neurobehavior and development

    Addressing potential adverse health risks of environmental chemicals (persistent organic pollutants, metals, cotinine, pesticides, flame retardants, BPA, and phthalates) on fetal, infant, and child neurobehavior. Examining their associations with endocrine function, body composition (DXA), neuroimaging (MRI/fMRI), cognition, learning and memory, motor skills, attention and executive function, behavior, and mental health. Also examining exposures at different developmental stages and measuring child neurobehavior.

    16wk & 26wk gestation, birth, 4wk postnatal, annually years 1-12.

  • Injury prevention measures and household injuries

    Test the efficacy of injury reduction controls in the homes of study participants. Assessed homes for potential injury hazards and installed child safety equipment. Collected parent report of injury events and validated the events against injuries tracked in the Hamilton County Injury Surveillance System

    Postnatally up to age 5 years

Study Arms (2)

Lead Reduction Arm

OTHER

random assignment to receive lead hazard control intervention. Assessing lead hazards in the home. Reducing lead hazards by cleaning, painting, covering, and/or replacing/repairing interior and exterior components of the home.

Procedure: Lead Hazard Control Intervention

Injury Reduction Arm

OTHER

random assignment to receive injury hazard control intervention. Assessing home for potential injury hazards. Controlling hazards by 1) installing safety equipment such as stairway gates, cabinet locks, smoke \& CO detectors, etc. 2) removing the hazards from the reach of a child and/or 3) restricting access to the hazards.

Procedure: Injury Hazard Control Intervention

Interventions

Lead Hazard Control InterventionPROCEDURE

Prior to their child's birth, participants randomized to Lead Reduction Group received lead hazard reduction controls to reduce residential exposure to lead.

Lead Reduction Arm
Injury Hazard Control InterventionPROCEDURE

Between 3 and 6 months of age, participants randomized to Injury Reduction Arm received injury hazard controls to reduce the number of residential injuries.

Injury Reduction Arm

Eligibility Criteria

Age18 Years+
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Pregnancy
  • Participating prenatal practice/clinic
  • Participating hospital

You may not qualify if:

  • Residence outside study area
  • Plans to move outside study area within 1 year
  • Home built after 1978
  • Less than 18 years of age
  • Beyond 19 weeks of gestation
  • Diagnosis of diabetes
  • Diagnosis of seizure disorder (taking anti-seizure medication)
  • Diagnosis of thyroid disorder
  • Diagnosis of AIDS or positive HIV test
  • Diagnosis of bipolar disorder
  • Diagnosis of schizophrenia
  • Diagnosis of cancer resulting in radiation treatment or chemotherapy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Cincinnati Children's Environmental Health Center

Cincinnati, Ohio, 45229, United States

Location

Related Publications (83)

  • Lanphear BP, Hornung R, Khoury J, Yolton K, Baghurst P, Bellinger DC, Canfield RL, Dietrich KN, Bornschein R, Greene T, Rothenberg SJ, Needleman HL, Schnaas L, Wasserman G, Graziano J, Roberts R. Low-level environmental lead exposure and children's intellectual function: an international pooled analysis. Environ Health Perspect. 2005 Jul;113(7):894-9. doi: 10.1289/ehp.7688.

    PMID: 16002379BACKGROUND

  • Phelan KJ, Khoury J, Xu Y, Lanphear B. Validation of a HOME Injury Survey. Inj Prev. 2009 Oct;15(5):300-6. doi: 10.1136/ip.2008.020958.

    PMID: 19805597BACKGROUND

  • Spanier AJ, Wilson S, Ho M, Hornung R, Lanphear BP. The contribution of housing renovation to children's blood lead levels: a cohort study. Environ Health. 2013 Aug 27;12:72. doi: 10.1186/1476-069X-12-72.

    PMID: 23981571BACKGROUND

  • Braun JM, Kalloo G, Chen A, Dietrich KN, Liddy-Hicks S, Morgan S, Xu Y, Yolton K, Lanphear BP. Cohort Profile: The Health Outcomes and Measures of the Environment (HOME) study. Int J Epidemiol. 2017 Feb 1;46(1):24. doi: 10.1093/ije/dyw006. No abstract available.

    PMID: 27006352BACKGROUND

  • Li N, Yolton K, Lanphear BP, Chen A, Kalkwarf HJ, Braun JM. Impact of Early-Life Weight Status on Cognitive Abilities in Children. Obesity (Silver Spring). 2018 Jun;26(6):1088-1095. doi: 10.1002/oby.22192.

    PMID: 29797555BACKGROUND

  • Bowers K, Khoury J, Sucharew H, Xu Y, Chen A, Lanphear B, Yolton K. Early Infant Attention as a Predictor of Social and Communicative Behavior in Childhood. Int J Behav Dev. 2019 May;43(3):204-211. doi: 10.1177/0165025418797001. Epub 2018 Sep 18.

    PMID: 37736344BACKGROUND

  • Goetz AR, Beebe DW, Peugh JL, Mara CA, Lanphear BP, Braun JM, Yolton K, Stark LJ. Longer sleep duration during infancy and toddlerhood predicts weight normalization among high birth weight infants. Sleep. 2019 Feb 1;42(2):zsy214. doi: 10.1093/sleep/zsy214.

    PMID: 30412240BACKGROUND

  • Sears CG, Braun JM, Ryan PH, Xu Y, Werner EF, Lanphear BP, Wellenius GA. The association of traffic-related air and noise pollution with maternal blood pressure and hypertensive disorders of pregnancy in the HOME study cohort. Environ Int. 2018 Dec;121(Pt 1):574-581. doi: 10.1016/j.envint.2018.09.049. Epub 2018 Oct 6.

    PMID: 30300815BACKGROUND

  • Geraghty SR, Khoury JC, Morrow AL, Lanphear BP. Reporting individual test results of environmental chemicals in breastmilk: potential for premature weaning. Breastfeed Med. 2008 Dec;3(4):207-13. doi: 10.1089/bfm.2008.0120.

    PMID: 19086823RESULT

  • Braun JM, Yolton K, Dietrich KN, Hornung R, Ye X, Calafat AM, Lanphear BP. Prenatal bisphenol A exposure and early childhood behavior. Environ Health Perspect. 2009 Dec;117(12):1945-52. doi: 10.1289/ehp.0900979. Epub 2009 Oct 6.

    PMID: 20049216RESULT

  • Braun JM, Daniels JL, Poole C, Olshan AF, Hornung R, Bernert JT, Khoury J, Needham LL, Barr DB, Lanphear BP. Prenatal environmental tobacco smoke exposure and early childhood body mass index. Paediatr Perinat Epidemiol. 2010 Nov;24(6):524-34. doi: 10.1111/j.1365-3016.2010.01146.x. Epub 2010 Aug 16.

    PMID: 20955230RESULT

  • Braun JM, Daniels JL, Poole C, Olshan AF, Hornung R, Bernert JT, Xia Y, Bearer C, Barr DB, Lanphear BP. A prospective cohort study of biomarkers of prenatal tobacco smoke exposure: the correlation between serum and meconium and their association with infant birth weight. Environ Health. 2010 Aug 27;9:53. doi: 10.1186/1476-069X-9-53.

    PMID: 20799929RESULT

  • Braun JM, Kalkbrenner AE, Calafat AM, Bernert JT, Ye X, Silva MJ, Barr DB, Sathyanarayana S, Lanphear BP. Variability and predictors of urinary bisphenol A concentrations during pregnancy. Environ Health Perspect. 2011 Jan;119(1):131-7. doi: 10.1289/ehp.1002366.

    PMID: 21205581RESULT

  • Wilson SE, Baker ER, Leonard AC, Eckman MH, Lanphear BP. Understanding preferences for disclosure of individual biomarker results among participants in a longitudinal birth cohort. J Med Ethics. 2010 Dec;36(12):736-40. doi: 10.1136/jme.2010.036517. Epub 2010 Oct 8.

    PMID: 20935315RESULT

  • Xu Y, Yolton K, Khoury J. Earliest appropriate time for administering neurobehavioral assessment in newborn infants. Pediatrics. 2011 Jan;127(1):e69-75. doi: 10.1542/peds.2010-1121. Epub 2010 Dec 20.

    PMID: 21172999RESULT

  • Braun JM, Kalkbrenner AE, Calafat AM, Yolton K, Ye X, Dietrich KN, Lanphear BP. Impact of early-life bisphenol A exposure on behavior and executive function in children. Pediatrics. 2011 Nov;128(5):873-82. doi: 10.1542/peds.2011-1335. Epub 2011 Oct 24.

    PMID: 22025598RESULT

  • Phelan KJ, Khoury J, Xu Y, Liddy S, Hornung R, Lanphear BP. A randomized controlled trial of home injury hazard reduction: the HOME injury study. Arch Pediatr Adolesc Med. 2011 Apr;165(4):339-45. doi: 10.1001/archpediatrics.2011.29.

    PMID: 21464382RESULT

  • Sathyanarayana S, Braun JM, Yolton K, Liddy S, Lanphear BP. Case report: high prenatal bisphenol a exposure and infant neonatal neurobehavior. Environ Health Perspect. 2011 Aug;119(8):1170-5. doi: 10.1289/ehp.1003064. Epub 2011 Apr 27.

    PMID: 21524981RESULT

  • Spanier AJ, Kahn RS, Xu Y, Hornung R, Lanphear BP. Comparison of biomarkers and parent report of tobacco exposure to predict wheeze. J Pediatr. 2011 Nov;159(5):776-82. doi: 10.1016/j.jpeds.2011.04.025. Epub 2011 Jun 8.

    PMID: 21645908RESULT

  • Spanier AJ, Kahn RS, Kunselman AR, Hornung R, Xu Y, Calafat AM, Lanphear BP. Prenatal exposure to bisphenol A and child wheeze from birth to 3 years of age. Environ Health Perspect. 2012 Jun;120(6):916-20. doi: 10.1289/ehp.1104175. Epub 2012 Feb 14.

    PMID: 22334053RESULT

  • Beebe DW, Rausch J, Byars KC, Lanphear B, Yolton K. Persistent snoring in preschool children: predictors and behavioral and developmental correlates. Pediatrics. 2012 Sep;130(3):382-9. doi: 10.1542/peds.2012-0045. Epub 2012 Aug 13.

    PMID: 22891224RESULT

  • Byars KC, Yolton K, Rausch J, Lanphear B, Beebe DW. Prevalence, patterns, and persistence of sleep problems in the first 3 years of life. Pediatrics. 2012 Feb;129(2):e276-84. doi: 10.1542/peds.2011-0372. Epub 2012 Jan 4.

    PMID: 22218837RESULT

  • Rauch SA, Braun JM, Barr DB, Calafat AM, Khoury J, Montesano AM, Yolton K, Lanphear BP. Associations of prenatal exposure to organophosphate pesticide metabolites with gestational age and birth weight. Environ Health Perspect. 2012 Jul;120(7):1055-60. doi: 10.1289/ehp.1104615. Epub 2012 Apr 5.

    PMID: 22476135RESULT

  • Sucharew H, Khoury JC, Xu Y, Succop P, Yolton K. NICU Network Neurobehavioral Scale profiles predict developmental outcomes in a low-risk sample. Paediatr Perinat Epidemiol. 2012 Jul;26(4):344-52. doi: 10.1111/j.1365-3016.2012.01288.x. Epub 2012 May 17.

    PMID: 22686386RESULT

  • Yolton K, Khoury J, Xu Y, Succop P, Lanphear B, Bernert JT, Lester B. Low-level prenatal exposure to nicotine and infant neurobehavior. Neurotoxicol Teratol. 2009 Nov-Dec;31(6):356-63. doi: 10.1016/j.ntt.2009.07.004. Epub 2009 Jul 17.

    PMID: 19619640RESULT

  • Yolton K, Xu Y, Strauss D, Altaye M, Calafat AM, Khoury J. Prenatal exposure to bisphenol A and phthalates and infant neurobehavior. Neurotoxicol Teratol. 2011 Sep-Oct;33(5):558-66. doi: 10.1016/j.ntt.2011.08.003. Epub 2011 Aug 10.

    PMID: 21854843RESULT

  • Braun JM, Kalkbrenner AE, Just AC, Yolton K, Calafat AM, Sjodin A, Hauser R, Webster GM, Chen A, Lanphear BP. Gestational exposure to endocrine-disrupting chemicals and reciprocal social, repetitive, and stereotypic behaviors in 4- and 5-year-old children: the HOME study. Environ Health Perspect. 2014 May;122(5):513-20. doi: 10.1289/ehp.1307261. Epub 2014 Mar 12.

    PMID: 24622245RESULT

  • Phelan KJ, Morrongiello BA, Khoury JC, Xu Y, Liddy S, Lanphear B. Maternal supervision of children during their first 3 years of life: the influence of maternal depression and child gender. J Pediatr Psychol. 2014 Apr;39(3):349-57. doi: 10.1093/jpepsy/jst090. Epub 2013 Dec 19.

    PMID: 24357732RESULT

  • Yolton K, Xu Y, Sucharew H, Succop P, Altaye M, Popelar A, Montesano MA, Calafat AM, Khoury JC. Impact of low-level gestational exposure to organophosphate pesticides on neurobehavior in early infancy: a prospective study. Environ Health. 2013 Sep 13;12(1):79. doi: 10.1186/1476-069X-12-79.

    PMID: 24034442RESULT

  • Braun JM, Lanphear BP, Calafat AM, Deria S, Khoury J, Howe CJ, Venners SA. Early-life bisphenol a exposure and child body mass index: a prospective cohort study. Environ Health Perspect. 2014 Nov;122(11):1239-45. doi: 10.1289/ehp.1408258. Epub 2014 Jul 29.

    PMID: 25073184RESULT

  • Braun JM, Froehlich T, Kalkbrenner A, Pfeiffer CM, Fazili Z, Yolton K, Lanphear BP. Brief report: are autistic-behaviors in children related to prenatal vitamin use and maternal whole blood folate concentrations? J Autism Dev Disord. 2014 Oct;44(10):2602-7. doi: 10.1007/s10803-014-2114-x.

    PMID: 24710813RESULT

  • Chen A, Yolton K, Rauch SA, Webster GM, Hornung R, Sjodin A, Dietrich KN, Lanphear BP. Prenatal polybrominated diphenyl ether exposures and neurodevelopment in U.S. children through 5 years of age: the HOME study. Environ Health Perspect. 2014 Aug;122(8):856-62. doi: 10.1289/ehp.1307562. Epub 2014 May 28.

    PMID: 24870060RESULT

  • Donauer S, Chen A, Xu Y, Calafat AM, Sjodin A, Yolton K. Prenatal exposure to polybrominated diphenyl ethers and polyfluoroalkyl chemicals and infant neurobehavior. J Pediatr. 2015 Mar;166(3):736-42. doi: 10.1016/j.jpeds.2014.11.021. Epub 2014 Dec 16.

    PMID: 25524317RESULT

  • Prasodjo A, Pfeiffer CM, Fazili Z, Xu Y, Liddy S, Yolton K, Savitz DA, Lanphear BP, Braun JM. Serum cotinine and whole blood folate concentrations in pregnancy. Ann Epidemiol. 2014 Jul;24(7):498-503.e1. doi: 10.1016/j.annepidem.2014.04.004. Epub 2014 Apr 24.

    PMID: 24854185RESULT

  • Spanier AJ, Kahn RS, Kunselman AR, Schaefer EW, Hornung R, Xu Y, Calafat AM, Lanphear BP. Bisphenol a exposure and the development of wheeze and lung function in children through age 5 years. JAMA Pediatr. 2014 Dec;168(12):1131-7. doi: 10.1001/jamapediatrics.2014.1397.

    PMID: 25286153RESULT

  • Watkins DJ, Eliot M, Sathyanarayana S, Calafat AM, Yolton K, Lanphear BP, Braun JM. Variability and predictors of urinary concentrations of phthalate metabolites during early childhood. Environ Sci Technol. 2014;48(15):8881-90. doi: 10.1021/es501744v. Epub 2014 Jul 9.

    PMID: 24977926RESULT

  • Kato K, Wong LY, Chen A, Dunbar C, Webster GM, Lanphear BP, Calafat AM. Changes in serum concentrations of maternal poly- and perfluoroalkyl substances over the course of pregnancy and predictors of exposure in a multiethnic cohort of Cincinnati, Ohio pregnant women during 2003-2006. Environ Sci Technol. 2014 Aug 19;48(16):9600-8. doi: 10.1021/es501811k. Epub 2014 Jul 29.

    PMID: 25026485RESULT

  • Barnard H, Rao R, Xu Y, Froehlich T, Epstein J, Lanphear BP, Yolton K. Association of the Conners' Kiddie Continuous Performance Test (K-CPT) Performance and Parent-Report Measures of Behavior and Executive Functioning. J Atten Disord. 2018 Sep;22(11):1056-1065. doi: 10.1177/1087054715578271. Epub 2015 Apr 6.

    PMID: 25846228RESULT

  • Braun JM, Chen A, Romano ME, Calafat AM, Webster GM, Yolton K, Lanphear BP. Prenatal perfluoroalkyl substance exposure and child adiposity at 8 years of age: The HOME study. Obesity (Silver Spring). 2016 Jan;24(1):231-7. doi: 10.1002/oby.21258. Epub 2015 Nov 11.

    PMID: 26554535RESULT

  • Romano ME, Webster GM, Vuong AM, Thomas Zoeller R, Chen A, Hoofnagle AN, Calafat AM, Karagas MR, Yolton K, Lanphear BP, Braun JM. Gestational urinary bisphenol A and maternal and newborn thyroid hormone concentrations: the HOME Study. Environ Res. 2015 Apr;138:453-60. doi: 10.1016/j.envres.2015.03.003. Epub 2015 Mar 17.

    PMID: 25794847RESULT

  • Vuong AM, Webster GM, Romano ME, Braun JM, Zoeller RT, Hoofnagle AN, Sjodin A, Yolton K, Lanphear BP, Chen A. Maternal Polybrominated Diphenyl Ether (PBDE) Exposure and Thyroid Hormones in Maternal and Cord Sera: The HOME Study, Cincinnati, USA. Environ Health Perspect. 2015 Oct;123(10):1079-85. doi: 10.1289/ehp.1408996. Epub 2015 Apr 17.

    PMID: 25893858RESULT

  • Werner EF, Braun JM, Yolton K, Khoury JC, Lanphear BP. The association between maternal urinary phthalate concentrations and blood pressure in pregnancy: The HOME Study. Environ Health. 2015 Sep 17;14:75. doi: 10.1186/s12940-015-0062-3.

    PMID: 26380974RESULT

  • Buckley JP, Engel SM, Braun JM, Whyatt RM, Daniels JL, Mendez MA, Richardson DB, Xu Y, Calafat AM, Wolff MS, Lanphear BP, Herring AH, Rundle AG. Prenatal Phthalate Exposures and Body Mass Index Among 4- to 7-Year-old Children: A Pooled Analysis. Epidemiology. 2016 May;27(3):449-58. doi: 10.1097/EDE.0000000000000436.

    PMID: 26745610RESULT

  • Engel SM, Bradman A, Wolff MS, Rauh VA, Harley KG, Yang JH, Hoepner LA, Barr DB, Yolton K, Vedar MG, Xu Y, Hornung RW, Wetmur JG, Chen J, Holland NT, Perera FP, Whyatt RM, Lanphear BP, Eskenazi B. Prenatal Organophosphorus Pesticide Exposure and Child Neurodevelopment at 24 Months: An Analysis of Four Birth Cohorts. Environ Health Perspect. 2016 Jun;124(6):822-30. doi: 10.1289/ehp.1409474. Epub 2015 Sep 29.

    PMID: 26418669RESULT

  • Xu Y, Khoury JC, Sucharew H, Dietrich K, Yolton K. Low-level gestational exposure to mercury and maternal fish consumption: Associations with neurobehavior in early infancy. Neurotoxicol Teratol. 2016 Mar-Apr;54:61-7. doi: 10.1016/j.ntt.2016.02.002. Epub 2016 Feb 12.

    PMID: 26876455RESULT

  • Harley KG, Engel SM, Vedar MG, Eskenazi B, Whyatt RM, Lanphear BP, Bradman A, Rauh VA, Yolton K, Hornung RW, Wetmur JG, Chen J, Holland NT, Barr DB, Perera FP, Wolff MS. Prenatal Exposure to Organophosphorous Pesticides and Fetal Growth: Pooled Results from Four Longitudinal Birth Cohort Studies. Environ Health Perspect. 2016 Jul;124(7):1084-92. doi: 10.1289/ehp.1409362. Epub 2015 Dec 18.

    PMID: 26685281RESULT

  • Donauer S, Altaye M, Xu Y, Sucharew H, Succop P, Calafat AM, Khoury JC, Lanphear B, Yolton K. An Observational Study to Evaluate Associations Between Low-Level Gestational Exposure to Organophosphate Pesticides and Cognition During Early Childhood. Am J Epidemiol. 2016 Sep 1;184(5):410-8. doi: 10.1093/aje/kwv447. Epub 2016 Aug 18.

    PMID: 27539379RESULT

  • Ehrhardt J, Xu Y, Khoury J, Yolton K, Lanphear B, Phelan K. Cognitive and motor abilities of young children and risk of injuries in the home. Inj Prev. 2017 Feb;23(1):16-21. doi: 10.1136/injuryprev-2016-042031. Epub 2016 Jul 19.

    PMID: 27435102RESULT

  • Percy Z, Xu Y, Sucharew H, Khoury JC, Calafat AM, Braun JM, Lanphear BP, Chen A, Yolton K. Gestational exposure to phthalates and gender-related play behaviors in 8-year-old children: an observational study. Environ Health. 2016 Aug 16;15(1):87. doi: 10.1186/s12940-016-0171-7.

    PMID: 27527835RESULT

  • Romano ME, Xu Y, Calafat AM, Yolton K, Chen A, Webster GM, Eliot MN, Howard CR, Lanphear BP, Braun JM. Maternal serum perfluoroalkyl substances during pregnancy and duration of breastfeeding. Environ Res. 2016 Aug;149:239-246. doi: 10.1016/j.envres.2016.04.034. Epub 2016 May 11.

    PMID: 27179585RESULT

  • Shoaff JR, Romano ME, Yolton K, Lanphear BP, Calafat AM, Braun JM. Prenatal phthalate exposure and infant size at birth and gestational duration. Environ Res. 2016 Oct;150:52-58. doi: 10.1016/j.envres.2016.05.033. Epub 2016 May 26.

    PMID: 27236572RESULT

  • Vuong AM, Braun JM, Sjodin A, Webster GM, Yolton K, Lanphear BP, Chen A. Prenatal Polybrominated Diphenyl Ether Exposure and Body Mass Index in Children Up To 8 Years of Age. Environ Health Perspect. 2016 Dec;124(12):1891-1897. doi: 10.1289/EHP139. Epub 2016 Jun 10.

    PMID: 27285825RESULT

  • Zhang H, Yolton K, Webster GM, Sjodin A, Calafat AM, Dietrich KN, Xu Y, Xie C, Braun JM, Lanphear BP, Chen A. Prenatal PBDE and PCB Exposures and Reading, Cognition, and Externalizing Behavior in Children. Environ Health Perspect. 2017 Apr;125(4):746-752. doi: 10.1289/EHP478. Epub 2016 Jul 6.

    PMID: 27385187RESULT

  • Vuong AM, Braun JM, Yolton K, Xie C, Webster GM, Sjodin A, Dietrich KN, Lanphear BP, Chen A. Prenatal and postnatal polybrominated diphenyl ether exposure and visual spatial abilities in children. Environ Res. 2017 Feb;153:83-92. doi: 10.1016/j.envres.2016.11.020. Epub 2016 Dec 1.

    PMID: 27915227RESULT

  • Braun JM, Bellinger DC, Hauser R, Wright RO, Chen A, Calafat AM, Yolton K, Lanphear BP. Prenatal phthalate, triclosan, and bisphenol A exposures and child visual-spatial abilities. Neurotoxicology. 2017 Jan;58:75-83. doi: 10.1016/j.neuro.2016.11.009. Epub 2016 Nov 23.

    PMID: 27888119RESULT

  • Vuong AM, Yolton K, Webster GM, Sjodin A, Calafat AM, Braun JM, Dietrich KN, Lanphear BP, Chen A. Prenatal polybrominated diphenyl ether and perfluoroalkyl substance exposures and executive function in school-age children. Environ Res. 2016 May;147:556-64. doi: 10.1016/j.envres.2016.01.008. Epub 2016 Jan 28.

    PMID: 26832761RESULT

  • Rosen-Carole CB, Auinger P, Howard CR, Brownell EA, Lanphear BP. Low-Level Prenatal Toxin Exposures and Breastfeeding Duration: A Prospective Cohort Study. Matern Child Health J. 2017 Dec;21(12):2245-2255. doi: 10.1007/s10995-017-2346-4.

    PMID: 28735496RESULT

  • Dasu K, Nakayama SF, Yoshikane M, Mills MA, Wright JM, Ehrlich S. An ultra-sensitive method for the analysis of perfluorinated alkyl acids in drinking water using a column switching high-performance liquid chromatography tandem mass spectrometry. J Chromatogr A. 2017 Apr 21;1494:46-54. doi: 10.1016/j.chroma.2017.03.006. Epub 2017 Mar 6.

    PMID: 28336137RESULT

  • Woods MM, Lanphear BP, Braun JM, McCandless LC. Gestational exposure to endocrine disrupting chemicals in relation to infant birth weight: a Bayesian analysis of the HOME Study. Environ Health. 2017 Oct 27;16(1):115. doi: 10.1186/s12940-017-0332-3.

    PMID: 29078782RESULT

  • Romano ME, Kalloo G, Etzel T, Braun JM. Re: Seasonal Variation in Exposure to Endocrine-disrupting Chemicals. Epidemiology. 2017 Sep;28(5):e42-e43. doi: 10.1097/EDE.0000000000000696. No abstract available.

    PMID: 28570386RESULT

  • Shoaff J, Papandonatos GD, Calafat AM, Ye X, Chen A, Lanphear BP, Yolton K, Braun JM. Early-Life Phthalate Exposure and Adiposity at 8 Years of Age. Environ Health Perspect. 2017 Sep 11;125(9):097008. doi: 10.1289/EHP1022.

    PMID: 28935615RESULT

  • Pell T, Eliot M, Chen A, Lanphear BP, Yolton K, Sathyanarayana S, Braun JM. Parental Concern about Environmental Chemical Exposures and Children's Urinary Concentrations of Phthalates and Phenols. J Pediatr. 2017 Jul;186:138-144.e3. doi: 10.1016/j.jpeds.2017.03.064. Epub 2017 May 2.

    PMID: 28476460RESULT

  • Millenson ME, Braun JM, Calafat AM, Barr DB, Huang YT, Chen A, Lanphear BP, Yolton K. Urinary organophosphate insecticide metabolite concentrations during pregnancy and children's interpersonal, communication, repetitive, and stereotypic behaviors at 8 years of age: The home study. Environ Res. 2017 Aug;157:9-16. doi: 10.1016/j.envres.2017.05.008. Epub 2017 May 11.

    PMID: 28501654RESULT

  • Stacy SL, Eliot M, Etzel T, Papandonatos G, Calafat AM, Chen A, Hauser R, Lanphear BP, Sathyanarayana S, Ye X, Yolton K, Braun JM. Patterns, Variability, and Predictors of Urinary Triclosan Concentrations during Pregnancy and Childhood. Environ Sci Technol. 2017 Jun 6;51(11):6404-6413. doi: 10.1021/acs.est.7b00325. Epub 2017 May 25.

    PMID: 28516781RESULT

  • Vuong AM, Yolton K, Xie C, Webster GM, Sjodin A, Braun JM, Dietrich KN, Lanphear BP, Chen A. Childhood polybrominated diphenyl ether (PBDE) exposure and neurobehavior in children at 8 years. Environ Res. 2017 Oct;158:677-684. doi: 10.1016/j.envres.2017.07.028. Epub 2017 Jul 19.

    PMID: 28734254RESULT

  • Stacy SL, Papandonatos GD, Calafat AM, Chen A, Yolton K, Lanphear BP, Braun JM. Early life bisphenol A exposure and neurobehavior at 8years of age: Identifying windows of heightened vulnerability. Environ Int. 2017 Oct;107:258-265. doi: 10.1016/j.envint.2017.07.021. Epub 2017 Jul 29.

    PMID: 28764921RESULT

  • Braun JM, Yolton K, Stacy SL, Erar B, Papandonatos GD, Bellinger DC, Lanphear BP, Chen A. Prenatal environmental chemical exposures and longitudinal patterns of child neurobehavior. Neurotoxicology. 2017 Sep;62:192-199. doi: 10.1016/j.neuro.2017.07.027. Epub 2017 Jul 20.

    PMID: 28736150RESULT

  • Zhang H, Yolton K, Webster GM, Ye X, Calafat AM, Dietrich KN, Xu Y, Xie C, Braun JM, Lanphear BP, Chen A. Prenatal and childhood perfluoroalkyl substances exposures and children's reading skills at ages 5 and 8years. Environ Int. 2018 Feb;111:224-231. doi: 10.1016/j.envint.2017.11.031. Epub 2017 Dec 20.

    PMID: 29241079RESULT

  • Kalloo G, Calafat AM, Chen A, Yolton K, Lanphear BP, Braun JM. Early life Triclosan exposure and child adiposity at 8 Years of age: a prospective cohort study. Environ Health. 2018 Mar 5;17(1):24. doi: 10.1186/s12940-018-0366-1.

    PMID: 29506550RESULT

  • Braun JM, Kalkwarf HJ, Papandonatos GD, Chen A, Lanphear BP. Patterns of early life body mass index and childhood overweight and obesity status at eight years of age. BMC Pediatr. 2018 May 11;18(1):161. doi: 10.1186/s12887-018-1124-9.

    PMID: 29751833RESULT

  • Jackson-Browne MS, Papandonatos GD, Chen A, Calafat AM, Yolton K, Lanphear BP, Braun JM. Identifying Vulnerable Periods of Neurotoxicity to Triclosan Exposure in Children. Environ Health Perspect. 2018 May 2;126(5):057001. doi: 10.1289/EHP2777.

    PMID: 29727133RESULT

  • Kingsley SL, Eliot MN, Kelsey KT, Calafat AM, Ehrlich S, Lanphear BP, Chen A, Braun JM. Variability and predictors of serum perfluoroalkyl substance concentrations during pregnancy and early childhood. Environ Res. 2018 Aug;165:247-257. doi: 10.1016/j.envres.2018.04.033. Epub 2018 May 7.

    PMID: 29734025RESULT

  • Romano ME, Eliot MN, Zoeller RT, Hoofnagle AN, Calafat AM, Karagas MR, Yolton K, Chen A, Lanphear BP, Braun JM. Maternal urinary phthalate metabolites during pregnancy and thyroid hormone concentrations in maternal and cord sera: The HOME Study. Int J Hyg Environ Health. 2018 May;221(4):623-631. doi: 10.1016/j.ijheh.2018.03.010. Epub 2018 Mar 23.

    PMID: 29606598RESULT

  • Li N, Arbuckle TE, Muckle G, Lanphear BP, Boivin M, Chen A, Dodds L, Fraser WD, Ouellet E, Seguin JR, Velez MP, Yolton K, Braun JM. Associations of cord blood leptin and adiponectin with children's cognitive abilities. Psychoneuroendocrinology. 2019 Jan;99:257-264. doi: 10.1016/j.psyneuen.2018.10.021. Epub 2018 Oct 25.

    PMID: 30390444RESULT

  • Braun JM, Hornung R, Chen A, Dietrich KN, Jacobs DE, Jones R, Khoury JC, Liddy-Hicks S, Morgan S, Vanderbeek SB, Xu Y, Yolton K, Lanphear BP. Effect of Residential Lead-Hazard Interventions on Childhood Blood Lead Concentrations and Neurobehavioral Outcomes: A Randomized Clinical Trial. JAMA Pediatr. 2018 Oct 1;172(10):934-942. doi: 10.1001/jamapediatrics.2018.2382.

    PMID: 30178064RESULT

  • Buck CO, Eliot MN, Kelsey KT, Calafat AM, Chen A, Ehrlich S, Lanphear BP, Braun JM. Prenatal exposure to perfluoroalkyl substances and adipocytokines: the HOME Study. Pediatr Res. 2018 Dec;84(6):854-860. doi: 10.1038/s41390-018-0170-1. Epub 2018 Sep 13.

    PMID: 30250302RESULT

  • Kalloo G, Wellenius GA, McCandless L, Calafat AM, Sjodin A, Karagas M, Chen A, Yolton K, Lanphear BP, Braun JM. Profiles and Predictors of Environmental Chemical Mixture Exposure among Pregnant Women: The Health Outcomes and Measures of the Environment Study. Environ Sci Technol. 2018 Sep 4;52(17):10104-10113. doi: 10.1021/acs.est.8b02946. Epub 2018 Aug 21.

    PMID: 30088764RESULT

  • Liang H, Vuong AM, Xie C, Webster GM, Sjodin A, Yuan W, Miao M, Braun JM, Dietrich KN, Yolton K, Lanphear BP, Chen A. Childhood polybrominated diphenyl ether (PBDE) serum concentration and reading ability at ages 5 and 8 years: The HOME Study. Environ Int. 2019 Jan;122:330-339. doi: 10.1016/j.envint.2018.11.026. Epub 2018 Nov 28.

    PMID: 30503319RESULT

  • Vuong AM, Braun JM, Webster GM, Thomas Zoeller R, Hoofnagle AN, Sjodin A, Yolton K, Lanphear BP, Chen A. Polybrominated diphenyl ether (PBDE) exposures and thyroid hormones in children at age 3 years. Environ Int. 2018 Aug;117:339-347. doi: 10.1016/j.envint.2018.05.019. Epub 2018 May 19.

    PMID: 29787984RESULT

  • Vuong AM, Braun JM, Yolton K, Wang Z, Xie C, Webster GM, Ye X, Calafat AM, Dietrich KN, Lanphear BP, Chen A. Prenatal and childhood exposure to perfluoroalkyl substances (PFAS) and measures of attention, impulse control, and visual spatial abilities. Environ Int. 2018 Oct;119:413-420. doi: 10.1016/j.envint.2018.07.013. Epub 2018 Jul 20.

    PMID: 30015313RESULT

  • Patel NB, Xu Y, McCandless LC, Chen A, Yolton K, Braun J, Jones RL, Dietrich KN, Lanphear BP. Very low-level prenatal mercury exposure and behaviors in children: the HOME Study. Environ Health. 2019 Jan 9;18(1):4. doi: 10.1186/s12940-018-0443-5.

    PMID: 30626382RESULT

  • Nussbaumer-Streit B, Mayr V, Dobrescu AI, Wagner G, Chapman A, Pfadenhauer LM, Lohner S, Lhachimi SK, Busert LK, Gartlehner G. Household interventions for secondary prevention of domestic lead exposure in children. Cochrane Database Syst Rev. 2020 Oct 6;10(10):CD006047. doi: 10.1002/14651858.CD006047.pub6.

    PMID: 33022752DERIVED

  • Braun JM, Buckley JP, Cecil KM, Chen A, Kalkwarf HJ, Lanphear BP, Xu Y, Woeste A, Yolton K. Adolescent follow-up in the Health Outcomes and Measures of the Environment (HOME) Study: cohort profile. BMJ Open. 2020 May 7;10(5):e034838. doi: 10.1136/bmjopen-2019-034838.

    PMID: 32385062DERIVED

Related Links

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

OverweightOvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Kimberly Yolton, PhD

    Children's Hospital Medical Center, Cincinnati

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
NIH
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 10, 2005

First Posted

August 11, 2005

Study Start

March 1, 2003

Primary Completion

August 1, 2018

Study Completion

August 1, 2018

Last Updated

March 6, 2020

Record last verified: 2020-03

Locations

US(1)