Health Effects of Diesel Exhaust in Asthmatic Patients: A Real-world Study in a London Street
1 other identifier
interventional
60
0 countries
N/A
Brief Summary
Acute exposure to diesel exhaust under normal city conditions leads to a worsening of symptoms of asthma, with reduction in lung function in asthmatic nonsmoking adults, dependent on the exposure dose and on the background severity of asthma. The worsening asthma is accompanied by increased oxidative stress and inflammation in the lungs.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable asthma
Started May 2003
Typical duration for not_applicable asthma
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2003
CompletedFirst Submitted
Initial submission to the registry
August 4, 2005
CompletedFirst Posted
Study publicly available on registry
August 5, 2005
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2006
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2006
CompletedResults Posted
Study results publicly available
October 11, 2019
CompletedNovember 5, 2019
October 1, 2019
3.3 years
August 4, 2005
September 13, 2019
October 22, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Spirometry, Percentage Change in FEV1 From Baseline
baseline, 24 hours after
Study Arms (2)
Asthma
EXPERIMENTALAsthma patients ranging from mild to severe
Healthy Non-Smokers
OTHERInterventions
Eligibility Criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Imperial College Londonlead
- Health Effects Institutecollaborator
Related Publications (1)
Zhang JJ, McCreanor JE, Cullinan P, Chung KF, Ohman-Strickland P, Han IK, Jarup L, Nieuwenhuijsen MJ. Health effects of real-world exposure to diesel exhaust in persons with asthma. Res Rep Health Eff Inst. 2009 Feb;(138):5-109; discussion 111-23.
PMID: 19449765RESULT
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Professor Fan Chung
- Organization
- Imperial College London
Study Officials
- PRINCIPAL INVESTIGATOR
Paul Cullinan, MD
Imperial College London
- STUDY DIRECTOR
Fan Chung, MD
Imperial College London
- PRINCIPAL INVESTIGATOR
Mark Nieuwenhuijsen, PhD
Imperial College London
- PRINCIPAL INVESTIGATOR
Jim Zhang, PhD
Rutgers U & UMDNJ
Publication Agreements
- PI is Sponsor Employee
- Yes
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
August 4, 2005
First Posted
August 5, 2005
Study Start
May 1, 2003
Primary Completion
August 1, 2006
Study Completion
August 1, 2006
Last Updated
November 5, 2019
Results First Posted
October 11, 2019
Record last verified: 2019-10
Data Sharing
- IPD Sharing
- Will not share