NCT00122889

Brief Summary

This study will determine whether garlic supplements affect the way certain drugs are processed in the body.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
80

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Jul 2005

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 2005

Completed
19 days until next milestone

First Submitted

Initial submission to the registry

July 20, 2005

Completed
2 days until next milestone

First Posted

Study publicly available on registry

July 22, 2005

Completed
3.6 years until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2009

Completed
Last Updated

January 1, 2010

Status Verified

December 1, 2009

First QC Date

July 20, 2005

Last Update Submit

December 30, 2009

Conditions

Healthy

Keywords

Drug InteractionsPharmacokineticsGarlicComplementary TherapiesComplementary and Alternative Medicine

Outcome Measures

Primary Outcomes (1)

  • Blood plasma and urine samples

    3 months

Secondary Outcomes (1)

  • Blood plasma and breath samples.

    3 months

Interventions

Garlic powder with high allicin contentDRUG
Garlic powder with low allicin contentDRUG
Garlic oilDRUG
Aged garlicDRUG

Eligibility Criteria

Age18 Years - 45 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)
Sampling MethodNon-Probability Sample
Study Population

Healthy volunteers

You may qualify if:

  • Body mass index (BMI) between 20 and 32
  • Able to read and understand English
  • MUST LIVE WITHIN THE SEATTLE, WA AREA.

You may not qualify if:

  • Current use of herbal medicines other than oral contraceptives
  • History of cardiopulmonary, liver, renal or endocrine disease
  • Allergy or sensitivity to any of the drugs that will be used in the probe cocktails or the garlic supplements
  • Daily consumption of vegetables with a high allium content, including garlic, shallots, leeks, and chives
  • Pregnancy or breastfeeding

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

Whole blood, urine

MeSH Terms

Interventions

allyl sulfide

Study Officials

  • Danny D. Shen, PhD

    Fred Hutchinson Cancer Center

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

July 20, 2005

First Posted

July 22, 2005

Study Start

July 1, 2005

Study Completion

March 1, 2009

Last Updated

January 1, 2010

Record last verified: 2009-12

Locations

US(1)