Nasal Ocular Reflexes Contribute to Eye Symptoms

NCT00117832 | Completed

• 1 other identifier: 13716A
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Eye symptoms of tearing, redness and itching frequently occur in patients with allergic rhinitis or hayfever. The purpose of this trial is to study whether placing an allergen (a substance that causes allergies) directly in your nose can cause you to have eye symptoms as well as nasal symptoms.

Conditions

Rhinitis, Allergic, Seasonal

Keywords

allergic rhinitis

Outcome Measures

Primary Outcomes (1)

• Amount of eye secretions collected on Schirmer strips following antigen challenge

Secondary Outcomes (1)

• Amount of eye secretions collected on Schirmer strips following antigen challenge

Interventions

Azelastine nasal spray DRUG

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• History of grass and/or ragweed allergic rhinitis.
• Positive skin test to grass and/or ragweed antigen.
• Positive response to screening nasal challenge.

You may not qualify if:

• Physical signs or symptoms suggestive of renal, hepatic or cardiovascular disease.
• Pregnant or lactating women.
• Upper respiratory infection within 14 days of study start.

Sponsors & Collaborators

• University of Chicago: lead
• GlaxoSmithKline: collaborator

Study Sites (1)

University of Chicago

Chicago, Illinois, 60637, United States

Location

Related Publications (39)

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• Baroody FM, Foster KA, Markaryan A, deTineo M, Naclerio RM. Nasal ocular reflexes and eye symptoms in patients with allergic rhinitis. Ann Allergy Asthma Immunol. 2008 Mar;100(3):194-9. doi: 10.1016/S1081-1206(10)60442-5.

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MeSH Terms

Conditions

Rhinitis, Allergic, Seasonal; Rhinitis, Allergic

Condition Hierarchy (Ancestors)

Rhinitis; Nose Diseases; Respiratory Tract Diseases; Respiratory Hypersensitivity; Otorhinolaryngologic Diseases; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Officials

• Robert M Naclerio, MD

  University of Chicago

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 30, 2005
• First Posted: July 8, 2005
• Study Start: March 1, 2005
• Primary Completion: May 1, 2006
• Study Completion: October 1, 2006
• Last Updated: September 5, 2013

Record last verified: 2013-09

Locations

US (1)