NCT00117481

Brief Summary

This is a 3-arm, multicenter, double-blind, randomized, placebo-controlled study to evaluate the efficacy of DR-2001 in endometriosis-related symptoms, primarily nonmenstrual pelvic pain, over a 12-week treatment period.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
90

participants targeted

Target at P50-P75 for phase_2

Timeline
Completed

Started Jun 2005

Geographic Reach
1 country

41 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2005

Completed
29 days until next milestone

First Submitted

Initial submission to the registry

June 30, 2005

Completed
7 days until next milestone

First Posted

Study publicly available on registry

July 7, 2005

Completed
2.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2007

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2007

Completed
Last Updated

May 9, 2014

Status Verified

May 1, 2014

Enrollment Period

2.5 years

First QC Date

June 30, 2005

Last Update Submit

May 8, 2014

Conditions

Keywords

endometriosispelvic painhormonal treatment

Outcome Measures

Primary Outcomes (1)

  • Mean change in nonmenstrual pelvic pain at end of treatment

    Baseline to Week 12/Early Withdrawal Visit

Secondary Outcomes (2)

  • Mean change in nonmenstrual pelvic pain and endometriosis-related symptoms

    Weeks 4, 8 and 12

  • Safety and tolerability of DR-2001

    Throughout study period

Study Arms (3)

1

EXPERIMENTAL
Drug: DR-2001a

2

EXPERIMENTAL
Drug: DR-2001b

3

PLACEBO COMPARATOR
Other: Placebo

Interventions

DR-2001a administered vaginally each month

1

DR-2001b administered vaginally each month

2
PlaceboOTHER

Placebo administered vaginally each month

3

Eligibility Criteria

Age18 Years - 45 Years
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Surgically sterilized (patient or partner), willing to use condoms throughout the study, or otherwise not at risk for pregnancy
  • Diagnosis of endometriosis within the last 5 years
  • Moderate or severe nonmenstrual pelvic pain
  • Premenopausal
  • Not pregnant or breastfeeding
  • Regular (24-35 day) menstrual cycles for at least 2 months

You may not qualify if:

  • Undiagnosed abnormal genital bleeding
  • Any contraindication to the use of hormonal therapy
  • Prior surgery for endometriosis
  • GnRH analog therapy within 5 months
  • Use of estrogens and/or progestins within 2 months
  • Pain symptoms unrelated to endometriosis
  • Any contraindication to the use of vaginal delivery systems

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (41)

Duramed Investigational Site

Enterprise, Alabama, 36330, United States

Location

Duramed Investigational Site

Montgomery, Alabama, 53717, United States

Location

Duramed Investigational Site

Phoenix, Arizona, 85032, United States

Location

Duramed Investigational Site

Tucson, Arizona, 85712, United States

Location

Duramed Investigational Site

Little Rock, Arkansas, 72205, United States

Location

Duramed Investigational Site

La Jolla, California, 92093, United States

Location

Duramed Investigational Site

San Diego, California, 92103, United States

Location

Duramed Investigational Site

Vista, California, 92083, United States

Location

Duramed Investigational Site

Colorado Springs, Colorado, 80909, United States

Location

Duramed Investigational Site

Clearwater, Florida, 33759, United States

Location

Duramed Investigational Site

Hudson, Florida, 34667, United States

Location

Duramed Investigational Site

Spring Hill, Florida, 34609, United States

Location

Duramed Investigational Site

Tampa, Florida, 33606, United States

Location

Duramed Investigational Site

West Palm Beach, Florida, 33409, United States

Location

Duramed Investigational Site

Decatur, Georgia, 30034, United States

Location

Duramed Investigational Site

Idaho Falls, Idaho, 83404, United States

Location

Duramed Investigational Site

La Grange Park, Illinois, 60526, United States

Location

Duramed Investigational Site

Maywood, Illinois, 60153, United States

Location

Duramed Investigational Site

Oak Brook, Illinois, 60523, United States

Location

Duramed Investigational Site

Louisville, Kentucky, 40291, United States

Location

Duramed Investigational Site

Ann Arbor, Michigan, 48109, United States

Location

Duramed Investigational Site

Reno, Nevada, 89502, United States

Location

Duramed Investigational Site

Princeton, New Jersey, 08502, United States

Location

Duramed Investigational Site

Port Jefferson, New York, 11777, United States

Location

Duramed Investigational Site

Chapel Hill, North Carolina, 27599, United States

Location

Duramed Investigational Site

Morganton, North Carolina, 28655, United States

Location

Duramed Investigational Site

Winston-Salem, North Carolina, 27103, United States

Location

Duramed Investigational Site

Columbus, Ohio, 43210, United States

Location

Duramed Investigational Site

Dayton, Ohio, 45432, United States

Location

Duramed Investigational Site

Oklahoma City, Oklahoma, 73112, United States

Location

Duramed Investigational Site

Jenkintown, Pennsylvania, 36116, United States

Location

Duramed Investigational Site

Florence, South Carolina, 29501, United States

Location

Duramed Investigational Site

Jackson, Tennessee, 38305, United States

Location

Duramed Investigational Site

Memphis, Tennessee, 38120, United States

Location

Duramed Investigational Site

Austin, Texas, 78737, United States

Location

Duramed Investigational Site

Dallas, Texas, 75231, United States

Location

Duramed Investigational Site

San Antonio, Texas, 78229, United States

Location

Duramed Investigational Site

Pleasant Grove, Utah, 84062, United States

Location

Duramed Investigational Site

Sandy City, Utah, 84070, United States

Location

Duramed Investigational Site

Norfolk, Virginia, 23607, United States

Location

Duramed Investigational Site

Virginia Beach, Virginia, 23456, United States

Location

MeSH Terms

Conditions

EndometriosisPelvic Pain

Condition Hierarchy (Ancestors)

Genital Diseases, FemaleFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesGenital DiseasesPainNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Duramed Protocol Chair

    Duramed Research, Inc.

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

June 30, 2005

First Posted

July 7, 2005

Study Start

June 1, 2005

Primary Completion

December 1, 2007

Study Completion

December 1, 2007

Last Updated

May 9, 2014

Record last verified: 2014-05

Locations