Trial to Reduce Antimicrobial Prophylaxis Errors (TRAPE)

NCT00114036 | Unknown

• 1 other identifier: R01HS011331-01A1
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 3

Brief Summary

The specific aims are to determine the incidence of medication errors related to antimicrobial prophylaxis for cardiovascular surgery, joint replacement surgery, and hysterectomies across a heterogeneous sample of hospitals; identify organizational and practitioner factors associated with error rates, and evaluate the effectiveness of a multifaceted intervention in reducing prophylaxis error rates compared to written feedback alone in a sample of 44 hospitals enrolled in the study using a rigorous group-randomized design.

Conditions

Cardiovascular Surgical Procedures; Arthroplasty, Replacement; Hysterectomy

Keywords

Antibiotic prophylaxis; Surgical wound infections

Outcome Measures

Primary Outcomes (1)

• Change in performance between hospitals in the intervention and hospitals in the control group on the proportion of prophylaxis administered within the recommended timeframes.

Secondary Outcomes (1)

• Change in performance on appropriate selection of drug, appropriate duration, appropriate number of doses pre-op, appropriate use of beta-lactams in patients with allergies.

Interventions

Quality improvement strategies BEHAVIORAL

Eligibility Criteria

• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Hospitals with a minimum number of surgeries per month

Sponsors & Collaborators

• Agency for Healthcare Research and Quality (AHRQ): lead
• Joint Commission on Accreditation of Healthcare Organizations: collaborator
• Society for Healthcare Epidemiology of America: collaborator
• Centers for Disease Control and Prevention: collaborator

Study Sites (3)

Joint Commission on Accreditation of Healthcare Organizations

Oakbrook Terrace, Illinois, 60181, United States

Location

Wake Forest University School of Medicine

Winston-Salem, North Carolina, 27157, United States

Location

University of Tennessee

Memphis, Tennessee, 38105, United States

Location

Related Publications (1)

• Kritchevsky SB, Braun BI, Bush AJ, Bozikis MR, Kusek L, Burke JP, Wong ES, Jernigan J, Davis CC, Simmons B; TRAPE Study Group. The effect of a quality improvement collaborative to improve antimicrobial prophylaxis in surgical patients: a randomized trial. Ann Intern Med. 2008 Oct 7;149(7):472-80, W89-93. doi: 10.7326/0003-4819-149-7-200810070-00007.

  PMID: 18838727 DERIVED

MeSH Terms

Conditions

Surgical Wound Infection

Condition Hierarchy (Ancestors)

Wound Infection; Infections; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Stephen B. Krichevsky, PhD

  Wake Forest University Health Sciences

  PRINCIPAL INVESTIGATOR

• Barbara I. Braun, PhD

  Joint Commission on Accreditation of Healthcare Organizations

  STUDY DIRECTOR

• Edward Wong, MD

  VA Office of Research and Development

  STUDY CHAIR

• Steve Solomon, MD

  Centers for Disease Control and Prevention

  STUDY CHAIR

• Bryan Simmons, MD

  Methodist Health System

  STUDY CHAIR

• Andrew J. Bush, PhD

  University of Tennessee

  STUDY CHAIR

• John Burke, MD

  LDS Hospital

  STUDY CHAIR

• Michele R. Bozikis, MPH

  Joint Commission on Accreditation of Healthcare Organizations

  STUDY CHAIR

• Linda Kusek, MPH

  Joint Commission on Accreditation of Healthcare Organizations

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: ECT
• Intervention Model: PARALLEL
• Sponsor Type: FED

Study Record Dates

• First Submitted: June 13, 2005
• First Posted: June 14, 2005
• Study Start: August 1, 2002
• Study Completion: December 1, 2005
• Last Updated: June 24, 2005

Record last verified: 2005-06

Locations

US (3)