The Effects of Microdermabrasion on Skin Remodeling

NCT00111254 | Completed

• 1 other identifier: Derm 486
• Study Type: interventional
• Target: 257
• Locations: 0 countries
• Sites: N/A

Brief Summary

This research project aims to study the effects of microdermabrasion, a technique causing minimal injury used to improve the appearance of fine lines, wrinkles, and scars. Subjects will undergo microdermabrasion, which is a gentle "sand-blasting" of the skin. We are interested in determining how this procedure works at rebuilding the skin following microdermabrasion.

Conditions

Healthy Skin; Skin Wrinkling

Keywords

microdermabrasion; skin; wrinkles; collagen; photoaging; wrinkled skin

Outcome Measures

Primary Outcomes (1)

• Observing changes over time with respect to the following biochemical endpoints: Procollagen I and III, matrix metalloproteinases (MMPs 1, 3, and 9), and several cytokines including Interleukins and Tumor Necrosis Factor.

  Group I: 1-4 weeks; Group II: 1-3 months

Secondary Outcomes (1)

• Changes in clinical features associated with sun-damaged or wrinkled skin.

  Group I: 1-4 weeks, Group II: 1-3 months

Study Arms (2)

1

EXPERIMENTAL

In group I, acute effect group, each subject will undergo microdermabrasion of the hip/buttock. Treatment will consist of 3 passes in different directions (horizontal, vertical and oblique) with the microdermabrasion handpiece (Parisian Peel, Prestige model, medical microdermabrasion device). 4mm punch biopsies will be performed in the treated area at 4hrs, 8hrs, and 24hrs post-treatment. In addition, one 4mm punch biopsy will be obtained from adjacent untreated skin.

Procedure: Microdermabrasion

2

EXPERIMENTAL

In group II, chronic effect group, each subject will undergo microdermabrasion of the face at weekly intervals for six weeks. Treatment will consist of 3 passes in different directions with the microdermabrasion handpiece (horizontal, vertical, and oblique). Aluminum oxide abrasion and negative pressure will be increased as tolerated by the patient. Two 2mm punch biopsies will be obtained prior to the first treatment and one week following the sixth treatment.

Procedure: Microdermabrasion

Interventions

Microdermabrasion PROCEDURE

Treatment will consist of 3 passes in different directions (horizontal, vertical and oblique) with the microdermabrasion handpiece (Parisian Peel, Prestige model, medical microdermabrasion device).

1; 2

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Ages 18 or older
• Patients must be available for follow up visits for biopsies to comply with the requirements of the protocol.
• Patients must sign and understand the informed consent prior to participation in the study.
• You must live within a reasonable driving distance of Ann Arbor, Michigan, and/or be able to attend all of the scheduled appointments during the study

You may not qualify if:

• Oral retinoid (vitamin-A like drugs) use within one year of entry into the study
• Topical retinoid use within 3 months of the study
• Patients with a history of excessive scarring
• Patients with significant medical history or concurrent illness which investigators feel is not safe for study participation
• Patients who have had any type of facial rejuvenation procedure or treatment (such as Botox injections, collagen implants, or chemical peels) within the past six months
• Non-compliant patients
• Pregnant women

Sponsors & Collaborators

• University of Michigan: lead

Related Publications (1)

• Karimipour DJ, Rittie L, Hammerberg C, Min VK, Voorhees JJ, Orringer JS, Sachs DL, Hamilton T, Fisher GJ. Molecular analysis of aggressive microdermabrasion in photoaged skin. Arch Dermatol. 2009 Oct;145(10):1114-22. doi: 10.1001/archdermatol.2009.231.

  PMID: 19841398 DERIVED

Study Officials

• John J Voorhees, MD

  University of Michigan

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: May 18, 2005
• First Posted: May 19, 2005
• Study Start: June 1, 2002
• Primary Completion: July 1, 2009
• Study Completion: July 1, 2009
• Last Updated: May 21, 2015

Record last verified: 2011-06