Siblings With Ischemic Stroke Study
SWISS
2 other identifiers
observational
900
2 countries
32
Brief Summary
The purpose of this study is to find the genes that increase the risk of developing an ischemic stroke using DNA samples collected from concordant (stroke-affected) sibling pairs.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Dec 2000
Longer than P75 for all trials
32 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2000
CompletedFirst Submitted
Initial submission to the registry
April 20, 2005
CompletedFirst Posted
Study publicly available on registry
April 21, 2005
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2009
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2011
CompletedSeptember 27, 2011
September 1, 2011
8.5 years
April 20, 2005
September 23, 2011
Conditions
Keywords
Eligibility Criteria
in-patient or out-patient clinics, local community
You may qualify if:
- Subject diagnosed by a study neurologist as having had a symptomatic ischemic stroke in the past.
- Head Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) done within 7 days of symptom onset confirms absence of etiology other than ischemic stroke.
- Subject reports having at least one living sibling with a stroke.
- Subject is 18 years of age or older.
You may not qualify if:
- The index ischemic stroke occurred within 48 hours after a cardiovascular or cerebrovascular procedure.
- The index ischemic stroke occurred within 60 days after a non-traumatic subarachnoid hemorrhage.
- The subject has brain biopsy-proven central nervous system vasculitis.
- The subject is known to have any one of the following genetic disorders: CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy), Fabry's disease, homocystinuria, MELAS (Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, Stroke), or sickle cell anemia.
- The subject has a mechanical aortic valve or mechanical mitral valve.
- The subject had untreated or actively treated bacterial endocarditis at the time of the index ischemic stroke.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (32)
University of South Alabama
Mobile, Alabama, 36617, United States
Mayo Clinic Arizona
Scottsdale, Arizona, 85054, United States
East Bay Region Assoc.
Berkeley, California, 94705, United States
Scripps Clinic
La Jolla, California, 92039, United States
University of California, Davis
Sacramento, California, 95817, United States
Mercy General Hospital
Sacramento, California, 95819, United States
Shands Jacksonville
Jacksonville, Florida, 32209, United States
Mayo Clinic College of Medicine Jacksonville
Jacksonville, Florida, 32224, United States
Florida Neurovascular Institute
Tampa, Florida, 33606, United States
Cleveland Clinic - Florida
Weston, Florida, 33331, United States
OSF St. Francis Medical Center
Peoria, Illinois, 61637, United States
Indiana University/Clarian Health Partners
Indianapolis, Indiana, 46202, United States
Mercy Medical Center
Sioux City, Iowa, 51101, United States
University of Maryland
Baltimore, Maryland, 21201, United States
Mayo Clinic
Rochester, Minnesota, 55905, United States
Washington University School of Medicine
St Louis, Missouri, 63110, United States
Rochester General Hospital
Rochester, New York, United States
Helen Hayes Hospital
West Haverstraw, New York, 10994, United States
Wake Forest University School of Medicine
Winston-Salem, North Carolina, 27157, United States
University of Cincinnati
Cincinnati, Ohio, 45267-0525, United States
Metro Health
Cleveland, Ohio, 44109, United States
Ohio State University
Columbus, Ohio, 43210, United States
University of Penn. Med. Center
Philadelphia, Pennsylvania, 19104, United States
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107, United States
Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
University of Virginia
Charlottesville, Virginia, 22908, United States
St. Mary's Medical Center
Huntington, West Virginia, 25702, United States
Luther Midelfort Clinic
Eau Claire, Wisconsin, 54703, United States
University of Wisconsin, Madison
Madison, Wisconsin, 53792, United States
Froedtert Memorial Lutheran
Milwaukee, Wisconsin, 53226, United States
Hospital Charles Le Moyne
Greenfield Park, Quebec, J4V2H1, Canada
L'Enfant-Jesus Hospital
Québec, Quebec, Canada
Biospecimen
Whole blood
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
James F. Meschia, M.D.
Mayo Clinic
Study Design
- Study Type
- observational
- Observational Model
- FAMILY BASED
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
April 20, 2005
First Posted
April 21, 2005
Study Start
December 1, 2000
Primary Completion
June 1, 2009
Study Completion
June 1, 2011
Last Updated
September 27, 2011
Record last verified: 2011-09