Idiopathic Anemia of Aging (IAA)

NCT00104169 | Terminated Phase 2

• 1 other identifier: AG0014
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this trial is to examine whether Epoetin Alfa, a hormone stimulating production of red blood cells, can reverse idiopathic anemia.

Conditions

Anemia; Aging

Keywords

Anemia; Frailty; Epoetin; Erythropoietin; EPO

Outcome Measures

Primary Outcomes (1)

• Response of Anemia

Secondary Outcomes (1)

• To determine if there is a beneficial effect of quality of life, cognitive function, and physical function.

Interventions

Epoetin Alfa DRUG

Eligibility Criteria

• Age: 70 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• years of age or older
• Diagnosed with anemia
• Hemoglobin level less than or equal to 11
• Able to perform most activities of daily living without restriction

You may not qualify if:

• History of serious heart, liver or kidney disease
• Cancer treated within the last year except for skin cancer (excluding melanoma)
• Problems with your immune system
• Received Epoetin Alfa within the last year

Sponsors & Collaborators

• National Institute on Aging (NIA): lead

Study Sites (1)

Harbor Hospital

Baltimore, Maryland, 21225, United States

Location

Related Publications (5)

• Cesari M, Penninx BW, Lauretani F, Russo CR, Carter C, Bandinelli S, Atkinson H, Onder G, Pahor M, Ferrucci L. Hemoglobin levels and skeletal muscle: results from the InCHIANTI study. J Gerontol A Biol Sci Med Sci. 2004 Mar;59(3):249-54. doi: 10.1093/gerona/59.3.m249.

  PMID: 15031309 BACKGROUND

• Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, Woodman RC. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood. 2004 Oct 15;104(8):2263-8. doi: 10.1182/blood-2004-05-1812. Epub 2004 Jul 6.

  PMID: 15238427 BACKGROUND

• Penninx BW, Guralnik JM, Onder G, Ferrucci L, Wallace RB, Pahor M. Anemia and decline in physical performance among older persons. Am J Med. 2003 Aug 1;115(2):104-10. doi: 10.1016/s0002-9343(03)00263-8.

  PMID: 12893395 BACKGROUND

• Chaves PH, Ashar B, Guralnik JM, Fried LP. Looking at the relationship between hemoglobin concentration and prevalent mobility difficulty in older women. Should the criteria currently used to define anemia in older people be reevaluated? J Am Geriatr Soc. 2002 Jul;50(7):1257-64. doi: 10.1046/j.1532-5415.2002.50313.x.

  PMID: 12133021 BACKGROUND

• Kikuchi M, Inagaki T, Shinagawa N. Five-year survival of older people with anemia: variation with hemoglobin concentration. J Am Geriatr Soc. 2001 Sep;49(9):1226-8. doi: 10.1046/j.1532-5415.2001.49241.x.

  PMID: 11559383 BACKGROUND

MeSH Terms

Conditions

Anemia; Frailty

Interventions

Epoetin Alfa

Condition Hierarchy (Ancestors)

Hematologic Diseases; Hemic and Lymphatic Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Erythropoietin; Colony-Stimulating Factors; Glycoproteins; Glycoconjugates; Carbohydrates; Hematopoietic Cell Growth Factors; Cytokines; Intercellular Signaling Peptides and Proteins; Peptides; Amino Acids, Peptides, and Proteins; Proteins; Biological Factors

Study Officials

• William Ershler, MD

  NIA, NIH

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: NON RANDOMIZED
• Purpose: TREATMENT
• Sponsor Type: NIH

Study Record Dates

• First Submitted: February 23, 2005
• First Posted: February 24, 2005
• Study Start: August 1, 2004
• Primary Completion: May 1, 2007
• Study Completion: May 1, 2007
• Last Updated: August 29, 2008

Record last verified: 2008-08

Locations

US (1)