NCT00098267

Brief Summary

This study will explore how bacteria colonize human teeth and how this process changes over the lifetime of individuals. It will include an investigation of transmission of bacteria that initiate colonization between adults and from adults to infants. Selected NIH scientists and members of their immediate families, including infants, are eligible for this study. Participants provide a small sample of saliva and a sample of bacteria collected by rubbing a cotton swab over the surfaces of the lower four incisors. Adults collect and submit their own specimens; a dentist collects specimens from children.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Dec 2004

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 2, 2004

Completed
4 days until next milestone

First Posted

Study publicly available on registry

December 6, 2004

Completed
1.6 years until next milestone

First Submitted

Initial submission to the registry

July 12, 2006

Completed
3.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 3, 2009

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 3, 2009

Completed
Last Updated

July 2, 2017

Status Verified

August 3, 2009

Enrollment Period

4.7 years

First QC Date

July 12, 2006

Last Update Submit

June 30, 2017

Conditions

Healthy

Keywords

BacteriaBiofilm FormationSecretory AntibodiesTeethHealth and Disease

Eligibility Criteria

Age3 Months+
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

  • Cisar JO, Sandberg AL, Abeygunawardana C, Reddy GP, Bush CA. Lectin recognition of host-like saccharide motifs in streptococcal cell wall polysaccharides. Glycobiology. 1995 Oct;5(7):655-62. doi: 10.1093/glycob/5.7.655.

    PMID: 8608267BACKGROUND

  • Takahashi Y, Sandberg AL, Ruhl S, Muller J, Cisar JO. A specific cell surface antigen of Streptococcus gordonii is associated with bacterial hemagglutination and adhesion to alpha2-3-linked sialic acid-containing receptors. Infect Immun. 1997 Dec;65(12):5042-51. doi: 10.1128/iai.65.12.5042-5051.1997.

    PMID: 9393794BACKGROUND

  • Takahashi Y, Ruhl S, Yoon JW, Sandberg AL, Cisar JO. Adhesion of viridans group streptococci to sialic acid-, galactose- and N-acetylgalactosamine-containing receptors. Oral Microbiol Immunol. 2002 Aug;17(4):257-62. doi: 10.1034/j.1399-302x.2002.170409.x.

    PMID: 12121477BACKGROUND

MeSH Terms

Conditions

Disease

Condition Hierarchy (Ancestors)

Pathologic ProcessesPathological Conditions, Signs and Symptoms

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

July 12, 2006

First Posted

December 6, 2004

Study Start

December 2, 2004

Primary Completion

August 3, 2009

Study Completion

August 3, 2009

Last Updated

July 2, 2017

Record last verified: 2009-08-03

Locations

US(1)