NCT00081562

Brief Summary

Ankylosing spondylitis (AS) is a chronic inflammatory disease that affects the joints between the vertebrae of the spine and the joints between the spine and the pelvis. The purpose of this study is to collect information and blood samples from patients with AS and their relatives for use in genetic studies.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,600

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Sep 1999

Longer than P75 for all trials

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 1999

Completed
4.6 years until next milestone

First Submitted

Initial submission to the registry

April 15, 2004

Completed
4 days until next milestone

First Posted

Study publicly available on registry

April 19, 2004

Completed
2.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2006

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2006

Completed
Last Updated

February 21, 2008

Status Verified

February 1, 2008

Enrollment Period

7.3 years

First QC Date

April 15, 2004

Last Update Submit

February 19, 2008

Conditions

SpondylitisAnkylosing Spondylitis

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Meet modified New York criteria for ankylosing spondylitis (AS)
  • AS as confirmed by X-rays of sacroiliac joints (between the pelvis and spine)
  • At least two siblings in family with AS
  • Parents of the participants with AS have the option of also being enrolled

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States

Location

University of Texas - Health Science Center at Houston

Houston, Texas, 77030, United States

Location

Related Publications (3)

  • Brown MA, Wordsworth BP, Reveille JD. Genetics of ankylosing spondylitis. Clin Exp Rheumatol. 2002 Nov-Dec;20(6 Suppl 28):S43-9.

    PMID: 12463446BACKGROUND

  • Tsui FW, Tsui HW, Cheng EY, Stone M, Payne U, Reveille JD, Shulman MJ, Paterson AD, Inman RD. Novel genetic markers in the 5'-flanking region of ANKH are associated with ankylosing spondylitis. Arthritis Rheum. 2003 Mar;48(3):791-7. doi: 10.1002/art.10844.

    PMID: 12632434BACKGROUND

  • Reveille JD. The genetic basis of spondyloarthritis. Curr Rheumatol Rep. 2004 Apr;6(2):117-25. doi: 10.1007/s11926-004-0056-6.

    PMID: 15016342BACKGROUND

Related Links

MeSH Terms

Conditions

SpondylitisSpondylitis, Ankylosing

Condition Hierarchy (Ancestors)

Bone Diseases, InfectiousInfectionsBone DiseasesMusculoskeletal DiseasesSpinal DiseasesAxial SpondyloarthritisSpondylarthropathiesSpondylarthritisAnkylosisJoint DiseasesArthritis

Study Officials

  • John D. Reveille, MD

    The University of Texas Health Science Center, Houston

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

April 15, 2004

First Posted

April 19, 2004

Study Start

September 1, 1999

Primary Completion

December 1, 2006

Study Completion

December 1, 2006

Last Updated

February 21, 2008

Record last verified: 2008-02

Locations

US(2)