NCT00076505

Completed

Cell Studies of Parkinson's Disease

National Human Genome Research Institute (NHGRI)Source

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Other study identifiers

Sponsor study identifier

040092

Secondary identifiers

04-HG-0092

Study Type

observational

Reported enrollment (type unavailable)

150

Locations

1 country

Sites

1

Timeline

Study Start

January 14, 2004

Date type not reported

This date has not been verified as actual or estimated.

Primary Completion

Not reported

Date not reported

Study Completion

November 30, 2006

Date type not reported

This date has not been verified as actual or estimated.

Brief Summary

This study will examine and compare blood samples from healthy volunteers and patients with Parkinson's disease to identify abnormalities associated with Parkinson's disease. Disease symptoms include slowness of movement, hand or leg shaking, and stiffness. Some patients have difficulty with balance. Information from this study may provide information on how Parkinson's disease affects the brain and body, and may help lead to a test for earlier diagnosis. Healthy volunteers and patients with Parkinson's disease who are 18 years of age or older may enroll in this study. Participants will undergo the following procedures:

Physical examination, including evaluation of strength, feeling, coordination, and balance
Blood drawing: 150 milliliters (about 10 tablespoons) of blood will be drawn
Personal and family medical history
Consent to access medical records for research purposes Blood samples will be examined for:
Genetic analysis
Study of specific proteins and lipids
Study of mitochondria (parts of cells that make energy)

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: completed
Reported enrollment (type unavailable): 150 participants
Study completion date: November 30, 2006
Date type not reported
This date has not been verified as actual or estimated.
Listed locations: 1 countries · 1 sites

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

Study Start
January 14, 2004
Date type not reported
This date has not been verified as actual or estimated.
First Submitted
January 23, 2004
Actual (reported)
First Posted
January 26, 2004
Actual (reported)
Study Completion
November 30, 2006
Date type not reported
This date has not been verified as actual or estimated.

Last Updated: July 2, 2017
Status Verified: November 30, 2006
Last Update Submitted: June 30, 2017

Conditions

Parkinson Disease

Keywords

MitochondriaProteasomeLipidPolymorphismGeneticParkinson's DiseaseParkinson DiseasePDHeredityParkinson Disease At RiskHealthy VolunteerHV

Eligibility Criteria

Age18 Years+

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

Individuals over the age of 18 from families in which an inherited form of parkinson's disease is apparent will be enrolled. These patients are already enrolled in the Genetic linkage analysis protocol 97-HG-0173.
The diagnosis of Parkinson's disease must be supported by accepted clinical criteria including: tremor, bradykinesia, rigidity and responsiveness to L-DOPA.

Sponsors & Collaborators

National Human Genome Research Institute (NHGRI)
NIHlead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Related Publications (1)

Leroy E, Boyer R, Auburger G, Leube B, Ulm G, Mezey E, Harta G, Brownstein MJ, Jonnalagada S, Chernova T, Dehejia A, Lavedan C, Gasser T, Steinbach PJ, Wilkinson KD, Polymeropoulos MH. The ubiquitin pathway in Parkinson's disease. Nature. 1998 Oct 1;395(6701):451-2. doi: 10.1038/26652. No abstract available.
PMID: 9774100BACKGROUND

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian DisordersBasal Ganglia DiseasesBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesMovement DisordersSynucleinopathiesNeurodegenerative Diseases

Study Design

Study Type: observational
Sponsor Type: NIH

Study Record Dates

First Submitted

January 23, 2004

First Posted

January 26, 2004

Study Start

January 14, 2004

Date type not reported

This date has not been verified as actual or estimated.

Study Completion

November 30, 2006

Date type not reported

This date has not been verified as actual or estimated.

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Unaffected family members found to be at risk, will also be enrolled.

The normal control group will be comprised of anonymous platelet donors from the NIH Department of Transfusion Medicine and of individuals over the age of 18 with no known neurological disorder and normal neurological examination matched by age and sex that may be actively recruited.

Individuals with Lewy Body disease (LBD) that meet current criteria for diagnosis (hallucinations, diurnal variation, and dementia associated with extrapyramidal symptoms within a one year period) will also be included in the study.

You may not qualify if:

Because some medications can alter mitochondrial function, patients on MAO inhibitors, antidiabetic sulfonylureas and benzodiazepines will be excluded from the study.
No person under the age of 18 will be enrolled in this study. This is due to the fact that, except for very rare occasions, Parkinson's disease affects only adults.

Contact the study team to confirm eligibility.

Last Updated

July 2, 2017

Record last verified: 2006-11-30

Source record

Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.

Source: ClinicalTrials.gov.

JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.

Registry identifier: NCT00076505
Data provider: ClinicalTrials.gov
Source updated: 2017-07-02
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:22:50 UTC

Locations

US(1)

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Study Completion

Conditions

Keywords

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations