NCT00067951

Brief Summary

The purpose of this research study is to determine if a new investigational diabetes drug is safe and effective in treating people who have Type II diabetes mellitus with very high HbA1c or FPG (fasting plasma glucose) levels. The HbA1c test, also called the hemoglobin A1c test or glycated hemoglobin test, is a measurement of the average amount of sugar in the blood over the last 2 to 3 months. FPG is a test that measures the amount of sugar in the blood after an 8 hour fast.

Trial Health

93
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
190

participants targeted

Target at P25-P50 for phase_3 diabetes-mellitus-type-2

Timeline
Completed

Started Oct 2003

Geographic Reach
5 countries

94 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 3, 2003

Completed
2 days until next milestone

First Posted

Study publicly available on registry

September 5, 2003

Completed
1 month until next milestone

Study Start

First participant enrolled

October 17, 2003

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 1, 2004

Completed
29 days until next milestone

Study Completion

Last participant's last visit for all outcomes

November 30, 2004

Completed
Last Updated

March 21, 2018

Status Verified

March 1, 2018

Enrollment Period

1 year

First QC Date

September 3, 2003

Last Update Submit

March 19, 2018

Conditions

Keywords

HyperglycemiaHbA1cHemoglobin A1cType 2 diabetes mellitus

Outcome Measures

Primary Outcomes (1)

  • Hemoglobin A1c (HbA1c) reduction after 24 weeks of treatment.

Secondary Outcomes (1)

  • Change in FPG, insulin,C-peptide, insulin sensitivity,beta cell function, free fatty acids, lipids. Change in weight, vital signs, clinical laboratory tests, and adverse experiences.

Interventions

Eligibility Criteria

Age18 Years - 70 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Laboratory result for HbA1c \>11% or FPG \>270mg/dL
  • Clinical diagnosis of Type II diabetes
  • Prior treatment with diet and/or exercise alone, or less than 15 days of prior treatment with an oral anti-diabetic medication or insulin.

You may not qualify if:

  • Women who are pregnant

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (94)

GSK Investigational Site

Anniston, Alabama, 36207, United States

Location

GSK Investigational Site

Chandler, Arizona, 85224, United States

Location

GSK Investigational Site

Phoenix, Arizona, 85014, United States

Location

GSK Investigational Site

Phoenix, Arizona, 85050, United States

Location

GSK Investigational Site

Tucson, Arizona, 85745, United States

Location

GSK Investigational Site

Encinitas, California, 92024, United States

Location

GSK Investigational Site

Fullerton, California, 92835, United States

Location

GSK Investigational Site

Los Banos, California, 93635, United States

Location

GSK Investigational Site

Mission Viejo, California, 92691, United States

Location

GSK Investigational Site

Jacksonville, Florida, 32204, United States

Location

GSK Investigational Site

Melbourne, Florida, 32901, United States

Location

GSK Investigational Site

Miami, Florida, 33156, United States

Location

GSK Investigational Site

Orlando, Florida, 32806, United States

Location

GSK Investigational Site

Saint Cloud, Florida, 34769, United States

Location

GSK Investigational Site

Atlanta, Georgia, 30308, United States

Location

GSK Investigational Site

Atlanta, Georgia, 30342, United States

Location

GSK Investigational Site

Fayetteville, Georgia, 30214, United States

Location

GSK Investigational Site

Woodstock, Georgia, 30189, United States

Location

GSK Investigational Site

Chicago, Illinois, 60607, United States

Location

GSK Investigational Site

Evansville, Indiana, 47713, United States

Location

GSK Investigational Site

Newburgh, Indiana, 47630, United States

Location

GSK Investigational Site

Slidell, Louisiana, 70461, United States

Location

GSK Investigational Site

Jackson, Mississippi, 39202, United States

Location

GSK Investigational Site

Chesterfield, Missouri, 63017, United States

Location

GSK Investigational Site

Kansas City, Missouri, 64111, United States

Location

GSK Investigational Site

St Louis, Missouri, 63376, United States

Location

GSK Investigational Site

Las Vegas, Nevada, 89103, United States

Location

GSK Investigational Site

Kingston, New York, 12401, United States

Location

GSK Investigational Site

New York, New York, 10024, United States

Location

GSK Investigational Site

New York, New York, 10029, United States

Location

GSK Investigational Site

New York, New York, 10032, United States

Location

GSK Investigational Site

Rochester, New York, 14609, United States

Location

GSK Investigational Site

Charlotte, North Carolina, 28210, United States

Location

GSK Investigational Site

Mogadore, Ohio, 44260, United States

Location

GSK Investigational Site

Downingtown, Pennsylvania, 19335, United States

Location

GSK Investigational Site

Warminster, Pennsylvania, 18974, United States

Location

GSK Investigational Site

West Chester, Pennsylvania, 19382, United States

Location

GSK Investigational Site

Johnson City, Tennessee, 37601, United States

Location

GSK Investigational Site

Arlington, Texas, 76017, United States

Location

GSK Investigational Site

Beaumont, Texas, 77701, United States

Location

GSK Investigational Site

Bryan, Texas, 77802, United States

Location

GSK Investigational Site

Corpus Christi, Texas, 78411, United States

Location

GSK Investigational Site

Dallas, Texas, 75230, United States

Location

GSK Investigational Site

Midland, Texas, 79705, United States

Location

GSK Investigational Site

San Antonio, Texas, 78221, United States

Location

GSK Investigational Site

San Antonio, Texas, 78237, United States

Location

GSK Investigational Site

Seattle, Washington, 98108, United States

Location

GSK Investigational Site

Spokane, Washington, 99207, United States

Location

GSK Investigational Site

Wenatchee, Washington, 98801, United States

Location

GSK Investigational Site

Camperdown, New South Wales, 2050, Australia

Location

GSK Investigational Site

St Leonards, New South Wales, 2065, Australia

Location

GSK Investigational Site

Wollongong, New South Wales, 2500, Australia

Location

GSK Investigational Site

Kippa-Ring, Queensland, 4021, Australia

Location

GSK Investigational Site

Woolloongabba, Queensland, 4102, Australia

Location

GSK Investigational Site

North Adelaide, South Australia, 5006, Australia

Location

GSK Investigational Site

Caulfield, Victoria, 3162, Australia

Location

GSK Investigational Site

Fremantle, Western Australia, 6959, Australia

Location

GSK Investigational Site

Perth, Western Australia, 6000, Australia

Location

GSK Investigational Site

Calgary, Alberta, T3E 0C5, Canada

Location

GSK Investigational Site

Coquitlam, British Columbia, V3K 3V9, Canada

Location

GSK Investigational Site

Langley, British Columbia, V3A 4H9, Canada

Location

GSK Investigational Site

Moncton, New Brunswick, E1G 1A7, Canada

Location

GSK Investigational Site

Halifax, Nova Scotia, B3K 5R3, Canada

Location

GSK Investigational Site

Brampton, Ontario, L6T 3T1, Canada

Location

GSK Investigational Site

Burlington, Ontario, L7M 4Y1, Canada

Location

GSK Investigational Site

Courtice, Ontario, L1E 3C3, Canada

Location

GSK Investigational Site

Kitchener, Ontario, N2C 2N9, Canada

Location

GSK Investigational Site

North Bay, Ontario, P1B 2H3, Canada

Location

GSK Investigational Site

Oshawa, Ontario, L1H 1C2, Canada

Location

GSK Investigational Site

Peterborough, Ontario, K9H 5G1, Canada

Location

GSK Investigational Site

Peterborough, Ontario, K9J 7B3, Canada

Location

GSK Investigational Site

Renfrew, Ontario, K7V 1P6, Canada

Location

GSK Investigational Site

Stoney Creek, Ontario, L8G 2V6, Canada

Location

GSK Investigational Site

Toronto, Ontario, M3J 1N2, Canada

Location

GSK Investigational Site

Laval, Quebec, H7T 2P5, Canada

Location

GSK Investigational Site

Montreal, Quebec, H1V 1X4, Canada

Location

GSK Investigational Site

Montreal, Quebec, H3S 2W1, Canada

Location

GSK Investigational Site

Montreal, Quebec, H4N 2W2, Canada

Location

GSK Investigational Site

Plessisville, Quebec, G6L 3J1, Canada

Location

GSK Investigational Site

Pointe-Claire, Quebec, H9R 4S3, Canada

Location

GSK Investigational Site

Saint Insidore de Dorchester, Quebec, G0S 2S0, Canada

Location

GSK Investigational Site

Saint-Marc-des-Carrieres, Quebec, G0A 4B0, Canada

Location

GSK Investigational Site

Sainte Jerome, Quebec, J7Z 5T3, Canada

Location

GSK Investigational Site

Sherbrooke, Quebec, J1H 1Z1, Canada

Location

GSK Investigational Site

Regina, Saskatchewan, S4P 3X1, Canada

Location

GSK Investigational Site

Saskatoon, Saskatchewan, S7K 0M5, Canada

Location

GSK Investigational Site

Auckland, 1311, New Zealand

Location

GSK Investigational Site

Auckland, 1701, New Zealand

Location

GSK Investigational Site

Christchurch, 8001, New Zealand

Location

GSK Investigational Site

Rotorua, 3201, New Zealand

Location

GSK Investigational Site

Wellington, 6035, New Zealand

Location

GSK Investigational Site

Pusan, 602-739, South Korea

Location

GSK Investigational Site

Seoul, 139-872, South Korea

Location

GSK Investigational Site

Uijeongbu-si, 480-821, South Korea

Location

Related Links

MeSH Terms

Conditions

Diabetes Mellitus, Type 2Hyperglycemia

Interventions

rosiglitazone-metformin combination

Condition Hierarchy (Ancestors)

Diabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Study Officials

  • GSK Clinical Trials

    GlaxoSmithKline

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 3
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 3, 2003

First Posted

September 5, 2003

Study Start

October 17, 2003

Primary Completion

November 1, 2004

Study Completion

November 30, 2004

Last Updated

March 21, 2018

Record last verified: 2018-03

Data Sharing

IPD Sharing
Will share

Patient-level data for this study will be made available through www.clinicalstudydatarequest.com following the timelines and process described on this site.

Available IPD Datasets

Statistical Analysis Plan (712753/004)Access
Informed Consent Form (712753/004)Access
Clinical Study Report (712753/004)Access
Study Protocol (712753/004)Access
Individual Participant Data Set (712753/004)Access
Dataset Specification (712753/004)Access
Annotated Case Report Form (712753/004)Access

Locations