Alzheimer's Disease Genetics Study

NCT00064870 | Recruiting

• 3 other identifiers: IA0042U24AG021886NIH grant U24 AG21886
• Study Type: observational
• Target: 10,000
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of the Alzheimer's Disease Genetics Study is to identify the genes that are responsible for causing Alzheimer's Disease (AD). One of the ways in which the risk factor genes for late onset AD can be investigated is by identifying and collecting genetic material from families with multiple members diagnosed with AD or dementia.

Conditions

Alzheimer Disease; Late Onset Alzheimer Disease; Dementia

Keywords

Alzheimer disease; Late Onset Alzheimer disease risk factor genes; Genetics; Initiative; Dementia

Outcome Measures

Primary Outcomes (1)

• Distribute biological specimens to qualified investigators for use in their research studies.

  Investigators will analyze the samples and publish de-identified results. These publications will help to further the knowledge in the field of dementia and potentially lead to new therapies and targets for therapies.

  Contact investigators annually for an update on progress and publication status.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Families with two or more members with Alzheimer's disease or dementia

You may qualify if:

• Two living family members diagnosed with AD or other dementia with any age of onset
• Biological samples available
• Fresh blood, or
• Immortalized lymphoblastic cell lines, or
• grams of frozen cerebral cortex; fixed samples are not accepted
• Please note: this study does not include genetic counseling; because no personal identifying information such as name or date of birth is attached to samples, results of individual tests are not available to participants or family members.

You may not qualify if:

• Member of a family that was included in the National Institute of Mental Health AD Genetics Sib Pair collection

Sponsors & Collaborators

• Indiana University: lead
• National Institute on Aging (NIA): collaborator

Study Sites (1)

Participants are being recruited from all over the United States

Nationwide, Indiana, 46202, United States

RECRUITING

Related Links

• NCRAD: the National Centralized Repository for Alzheimer's Disease and Related Dementias

Biospecimen

Retention: SAMPLES WITH DNA

blood samples, brain tissue, cell lines

MeSH Terms

Conditions

Alzheimer Disease; Dementia

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders

Study Officials

• Tatiana M. Foroud, PhD

  National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD), Indiana University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Coordinator

CONTACT

1-800-526-2839; alzstudy@iu.edu

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Department Chair

Study Record Dates

• First Submitted: July 14, 2003
• First Posted: July 16, 2003
• Study Start: June 1, 2002
• Primary Completion (Estimated): July 1, 2026
• Study Completion (Estimated): July 1, 2026
• Last Updated: October 1, 2025

Record last verified: 2025-04

Locations

US (1)