NCT00064805

Brief Summary

Adults who sustain brain damage due to stroke, head injury, or traumatic surgery may develop difficulty reading. This study examines the effectiveness of behavior-based programs to improve reading ability in these individuals.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
58

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Aug 2002

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2002

Completed
12 months until next milestone

First Submitted

Initial submission to the registry

July 14, 2003

Completed
1 day until next milestone

First Posted

Study publicly available on registry

July 15, 2003

Completed
4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2007

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2007

Completed
Last Updated

August 15, 2014

Status Verified

April 1, 2014

Enrollment Period

4.9 years

First QC Date

July 14, 2003

Last Update Submit

August 13, 2014

Conditions

Dyslexia, AcquiredBrain InjuriesCerebrovascular Accident

Keywords

Cognitive therapyAphasia therapyAlexiaAcquired dyslexiaPhonological deficitsOrthographic deficitsBrain disordersBrain injuryStroke

Outcome Measures

Primary Outcomes (1)

  • Improved accuracy and/or speed of reading individual words aloud.

Secondary Outcomes (1)

  • Improved accuracy and/or speed of reading text aloud.

Interventions

Cognitive Therapy to Improve ReadingBEHAVIORAL

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Reading deficit subsequent to stroke, traumatic brain injury, brain surgery, or other brain damage
  • Ability to attend 2-3 sessions per week for several months at Georgetown University in Washington, DC

You may not qualify if:

  • History of developmental dyslexia or learning disabilities
  • Best corrected vision less than 20/40
  • Less than 10 years of formal education
  • Significant memory or comprehension problems

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Georgetown University Medical Center

Washington D.C., District of Columbia, 20057, United States

Location

Related Publications (8)

  • Friedman RB, Lott SN. Rapid word identification in pure alexia is lexical but not semantic. Brain Lang. 2000 May;72(3):219-37. doi: 10.1006/brln.2000.2286.

    PMID: 10764518BACKGROUND

  • Nitzberg Lott S, Friedman RB. Can treatment for pure alexia improve letter-by-letter reading speed without sacrificing accuracy? Brain Lang. 1999 May;67(3):188-201. doi: 10.1006/brln.1999.2054.

    PMID: 10210630BACKGROUND

  • Friedman RB, Sample DM, Lott SN. The role of level of representation in the use of paired associate learning for rehabilitation of alexia. Neuropsychologia. 2002;40(2):223-34. doi: 10.1016/s0028-3932(01)00098-7.

    PMID: 11640944BACKGROUND

  • Marchand Y, Friedman RB. Impaired oral reading in two atypical dyslexics: a comparison with a computational lexical-analogy model. Brain Lang. 2005 Jun;93(3):255-66. doi: 10.1016/j.bandl.2004.10.013. Epub 2004 Dec 15.

    PMID: 15862852BACKGROUND

  • Lott SN, Sample DM, Oliver RT, Lacey EH, Friedman RB. A patient with phonologic alexia can learn to read "much" from "mud pies". Neuropsychologia. 2008 Aug;46(10):2515-23. doi: 10.1016/j.neuropsychologia.2008.04.004. Epub 2008 Apr 16.

    PMID: 18513760BACKGROUND

  • Lott SN, Carney AS, Glezer LS, Friedman RB. Overt use of a tactile-kinesthetic strategy shifts to covert processing in rehabilitation of letter-by-letter reading. Aphasiology. 2010 Nov;24(11):1424-1442. doi: 10.1080/02687030903580333.

    PMID: 21170161BACKGROUND

  • Lacey EH, Lott SN, Snider SF, Sperling A, Friedman RB. Multiple Oral Re-reading treatment for alexia: The parts may be greater than the whole. Neuropsychol Rehabil. 2010 Aug;20(4):601-23. doi: 10.1080/09602011003710993. Epub 2010 Jul 6.

    PMID: 20574915BACKGROUND

  • Kurland J, Cortes CR, Wilke M, Sperling AJ, Lott SN, Tagamets MA, Vanmeter J, Friedman RB. Neural Mechanisms Underlying Learning following Semantic Mediation Treatment in a case of Phonologic Alexia. Brain Imaging Behav. 2008 Sep;2(3):147. doi: 10.1007/s11682-008-9027-2.

    PMID: 20119495BACKGROUND

Related Links

MeSH Terms

Conditions

Dyslexia, AcquiredBrain InjuriesStrokeDyslexiaBrain Diseases

Condition Hierarchy (Ancestors)

Language DisordersCommunication DisordersNeurobehavioral ManifestationsNeurologic ManifestationsNervous System DiseasesSpecific Learning DisorderLearning DisabilitiesSigns and SymptomsPathological Conditions, Signs and SymptomsNeurocognitive DisordersMental DisordersNeurodevelopmental DisordersCentral Nervous System DiseasesCraniocerebral TraumaTrauma, Nervous SystemWounds and InjuriesCerebrovascular DisordersVascular DiseasesCardiovascular Diseases

Study Officials

  • Rhonda B. Friedman, Ph.D.

    Georgetown University Medical School

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
NIH

Study Record Dates

First Submitted

July 14, 2003

First Posted

July 15, 2003

Study Start

August 1, 2002

Primary Completion

July 1, 2007

Study Completion

July 1, 2007

Last Updated

August 15, 2014

Record last verified: 2014-04

Locations

US(1)