MRI Study of Musculoskeletal Function

NCT00051857 | Recruiting

• 2 other identifiers: 03006003-CC-0060
• Study Type: observational
• Target: 750
• Locations: 1 country
• Sites: 1

Brief Summary

This study will use magnetic resonance imaging (MRI) and ultrasound images to study how muscles, tendons, and bones work together to cause motion. The procedure is one of several tools being developed to characterize normal and impaired musculoskeletal function, with the goal of developing improved methods of diagnosis and treatment of movement disorders. Healthy normal volunteers must be age 5 to unlimited, with or without joint impairment, may be eligible for this study. Volunteers with joint impairment may not have serious injury to the joint being studied, previous surgery on the joint being studied, or extreme pain at the joint being studied. MRI uses a strong magnet and radio waves to create images of the inside of the body. The subject lies on a long narrow couch inside a metal cylinder (the scanner) for up to 3 hours while the scanner gathers data. Earplugs are worn to muffle loud noises caused by electrical switching of radiofrequency circuits used in the scanning process. A special pad or tube may be placed over or around the region being scanned to improve the quality of the data. The subject will be asked to repeatedly move a specific joint, such as the knee, for brief periods, usually less than 5 minutes. The subject can communicate via intercom with the person performing the study at all times during the procedure, and may request to stop the study at any time.

Conditions

Abnormalities; Imaging; Patellofemoral Pain Syndrome

Keywords

Patello-Femoral; Knee; Motion; MRI; Kinematics; Natural History

Outcome Measures

Primary Outcomes (1)

• Dynamic MRI measures of in vivo tissue velocity, bone and muscle, during dynamic tasks of knee flexion/extension

  MRI techniques to non-invasively measure the 3D in vivo musculoskeletal kinematics, bone shapes, and muscle-tendon lengths in the joints of normal volunteers and healthy volunteers with specific joint impairments.

  End of study

Secondary Outcomes (1)

• B-mode ultra-sound of muscles and bones that compose the knee joint

  End of study

Study Arms (2)

1/Healthy Controls

Subjects 5 years old and up with musculoskeletal impairment, pathology, or variant.

2/Healthy Volunteers

Subjects 5 years old and up without musculoskeletal impairment, pathology, or variant.

Eligibility Criteria

• Age: 5 Years - 95 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Participants will be primarily recruited from the greater Washington DC area.

You may qualify if:

• Affected Participants:
• Must be between the ages of 5-95 years.
• Minors \< 18 years of age, they must be capable of providing assent (verbal or written) with parental or legal guardian permissions obtained.
• Adults 18 \>= years of age, they must be able to provide informed consent.
• Have the presence of a bone, muscle, soft tissue, connective tissue injury, impairment or related muscular skeletal system pathology.
• Ability to have an MRI Scan.
• Healthy Volunteer Participants
• Must be between the ages of 5-95 years.
• Minors \< 18 years of age, they must be capable of providing assent (verbal or written) with parental or legal guardian permissions obtained.
• Adults 18 \>= years of age, they must be able to provide informed consent.
• Ability to have an MRI Scan.

You may not qualify if:

• Affected Participants:
• For the MR imaging portion of this study, all participants must complete the NIH Diagnostic Radiology screening questionnaire. If any potential contraindication is found, either the volunteer s doctor (with knowledge of the potential contraindication) or the radiology department at the NIH will be contacted to determine if the potential contraindication would exclude them from the specific MR scans being proposed.
• Healthy Volunteer Participants
• Any relevant medical problems
• Clinical signs of an impairment in the joint/limb being studied.
• Any serious injury to the joint/limb being studied, previous surgery on the joint/limb being studied or extreme pain at the joint/limb being studied.
• Neurologic Pathology affecting the muscular skeletal system
• For the MR imaging portion of this study, all participants must complete the NIH Diagnostic Radiology screening questionnaire. If any potential contraindication is found, either the volunteer s doctor (with knowledge of the potential contraindication) or the radiology department at the NIH will be contacted to determine if the potential contraindication would exclude them from the specific MR scans being proposed.

Sponsors & Collaborators

• National Institutes of Health Clinical Center (CC): lead

Study Sites (1)

National Institutes of Health Clinical Center

Bethesda, Maryland, 20892, United States

RECRUITING

Related Links

• NIH Clinical Center Detailed Web Page

MeSH Terms

Conditions

Congenital Abnormalities; Patellofemoral Pain Syndrome

Condition Hierarchy (Ancestors)

Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Joint Diseases; Musculoskeletal Diseases

Study Officials

• Frances T Gavelli, Ph.D.

  National Institutes of Health Clinical Center (CC)

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Frances T Gavelli, Ph.D.

CONTACT

(301) 451-7585; gavellif@cc.nih.gov

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 16, 2003
• First Posted: January 17, 2003
• Study Start: March 5, 2003
• Last Updated: April 14, 2026

Record last verified: 2026-01-23

Data Sharing

• IPD Sharing: Will share
• Shared Documents: CSR
• Time Frame: Data will be shared through data sharing agreements.@@@@@@@@@@@@The start and end date will be determined by the data sharing agreement.
• Access Criteria: Data will be shared stripped of PII and with IRB approval.

Locations

US (1)