Chemotherapy and Radiation Therapy in Treating Patients With Locally Advanced Pancreatic Cancer
A Randomized Phase II Study Of Gemcitabine Plus Radiotherapy Vs. Gemcitabine, 5-Fluorouracil And Cisplatin Followed By Radiotherapy And 5-Fluoraracil For Patients With Locally Advanced, Potentially Resectable Pancreatic Adenocarcinoma
2 other identifiers
interventional
N/A
1 country
137
Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining chemotherapy with radiation therapy before surgery may shrink the tumor so that it can be removed during surgery. PURPOSE: Randomized phase II trial to compare the effectiveness of two different regimens combining chemotherapy with radiation therapy in treating patients who are undergoing surgery for locally advanced pancreatic cancer.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
Started Oct 2003
Typical duration for phase_2 pancreatic-cancer
137 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 12, 2002
CompletedFirst Posted
Study publicly available on registry
January 27, 2003
CompletedStudy Start
First participant enrolled
October 13, 2003
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2005
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2009
CompletedJune 15, 2023
June 1, 2023
2 years
November 12, 2002
June 13, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Percentage of margin-free resections produced by each program
Secondary Outcomes (7)
Efficacy as measured by CT scan response
Post-treatment fibrosis in the resected specimens
Toxicity
Duration of objective response
Disease-free survival
- +2 more secondary outcomes
Interventions
Eligibility Criteria
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Sponsors & Collaborators
Study Sites (137)
CCOP - Mayo Clinic Scottsdale Oncology Program
Scottsdale, Arizona, 85259, United States
Yale Comprehensive Cancer Center
New Haven, Connecticut, 06520-8032, United States
Lynn Regional Cancer Center of Boca Raton Community Hospital
Boca Raton, Florida, 33486, United States
University of Florida Shands Cancer Center
Gainesville, Florida, 32610, United States
Mayo Clinic - Jacksonville
Jacksonville, Florida, 32224-9980, United States
Emory University Hospital - Atlanta
Atlanta, Georgia, 30322, United States
Veterans Affairs Medical Center - Atlanta (Decatur)
Decatur, Georgia, 30033, United States
Medical Center of Central Georgia
Macon, Georgia, 31208, United States
Rush-Copley Cancer Care Center
Aurora, Illinois, 60507, United States
St. Joseph Medical Center
Bloomington, Illinois, 61701, United States
Graham Hospital
Canton, Illinois, 61520, United States
Memorial Hospital
Carthage, Illinois, 62321, United States
Hematology and Oncology Associates
Chicago, Illinois, 60611, United States
Robert H. Lurie Comprehensive Cancer Center at Northwestern University
Chicago, Illinois, 60611, United States
Veterans Affairs Medical Center - Lakeside Chicago
Chicago, Illinois, 60611, United States
Mercy Hospital and Medical Center
Chicago, Illinois, 60616, United States
Swedish Covenant Hospital
Chicago, Illinois, 60625, United States
St. Anthony's Memorial Hospital
Effingham, Illinois, 62401, United States
Eureka Hospital
Eureka, Illinois, 61530, United States
Evanston Northwestern Health Care - Evanston Hospital
Evanston, Illinois, 60201, United States
Galesburg Clinic
Galesburg, Illinois, 61401, United States
Galesburg Cottage Hospital
Galesburg, Illinois, 61401, United States
InterCommunity Cancer Center of Western Illinois
Galesburg, Illinois, 61401, United States
Mason District Hospital
Havana, Illinois, 62644, United States
Hopedale Medical Complex
Hopedale, Illinois, 61747, United States
Midwest Center for Hematology/Oncology
Joliet, Illinois, 60432, United States
Joliet Oncology Hematology Associates, Limited - West
Joliet, Illinois, 60435, United States
Kewanee Hospital
Kewanee, Illinois, 61443, United States
Deerpath Medical Associates
Lake Forest, Illinois, 60045, United States
North Shore Oncology and Hematology Associates, Limited - Libertyville
Libertyville, Illinois, 60048, United States
McDonough District Hospital
Macomb, Illinois, 61455, United States
Northwest Medical Specialist P.C.
Niles, Illinois, 60714, United States
BroMenn Regional Medical Center
Normal, Illinois, 61761, United States
Community Cancer Center
Normal, Illinois, 61761, United States
Community Hospital of Ottawa
Ottawa, Illinois, 61350, United States
Oncology Hematology Associates of Central Illinois - Ottawa
Ottawa, Illinois, 61350, United States
Cancer Treatment Center at Pekin Hospital
Pekin, Illinois, 61554, United States
Methodist Medical Center of Illinois
Peoria, Illinois, 61603, United States
Proctor Hospital
Peoria, Illinois, 61614, United States
CCOP - Illinois Oncology Research Association
Peoria, Illinois, 61615, United States
Oncology/Hematology Associates of Central Illinois, P.C.
Peoria, Illinois, 61615, United States
OSF St. Francis Medical Center
Peoria, Illinois, 61637, United States
Illinois Valley Community Hospital
Peru, Illinois, 61354, United States
Perry Memorial Hospital
Princeton, Illinois, 61356, United States
Swedish American Hospital
Rockford, Illinois, 61104, United States
Hematology Oncology Associates - Skokie
Skokie, Illinois, 60076, United States
Hematology/Oncology of the North Shore
Skokie, Illinois, 60076, United States
Midwest Cancer Research Group, Incorporated
Skokie, Illinois, 60077, United States
St. Margaret's Hospital
Spring Valley, Illinois, 61362, United States
Valley Cancer Center
Spring Valley, Illinois, 61362, United States
Carle Cancer Center at Carle Foundation Hospital
Urbana, Illinois, 61801, United States
CCOP - Carle Cancer Center
Urbana, Illinois, 61801, United States
Elkhart General Hospital
Elkhart, Indiana, 46515, United States
Center for Cancer Therapy at LaPorte Hospital and Health Services
La Porte, Indiana, 46350, United States
Saint Anthony Memorial Health Centers
Michigan City, Indiana, 46360, United States
Saint Joseph Regional Medical Center - Plymouth Campus
Plymouth, Indiana, 46544, United States
CCOP - Northern Indiana CR Consortium
South Bend, Indiana, 46601, United States
Memorial Hospital of South Bend
South Bend, Indiana, 46601, United States
McFarland Clinic, P.C.
Ames, Iowa, 50010, United States
Siouxland Regional Cancer Center
Sioux City, Iowa, 51101-1733, United States
Siouxland Hematology-Oncology Associates
Sioux City, Iowa, 51101, United States
Mercy Medical Center - Sioux City
Sioux City, Iowa, 51104, United States
St. Luke's Regional Medical Center
Sioux City, Iowa, 51104, United States
Cancer Center of Kansas - Chanute
Chanute, Kansas, 66720, United States
Cancer Center of Kansas - Dodge City
Dodge City, Kansas, 67801, United States
Cancer Center of Kansas, P.A. - El Dorado
El Dorado, Kansas, 67042, United States
Cancer Center of Kansas - Kingman
Kingman, Kansas, 67068, United States
Southwest Medical Center
Liberal, Kansas, 67901, United States
Cancer Center of Kansas - Newton
Newton, Kansas, 67114, United States
Cancer Center of Kansas - Ottawa
Ottawa, Kansas, 66067, United States
Cancer Center of Kansas, P.A. - Parsons
Parsons, Kansas, 67357, United States
Pratt Cancer Center of Kansas
Pratt, Kansas, 67124, United States
Cancer Center of Kansas - Salina
Salina, Kansas, 67042, United States
Cancer Center of Kansas - Wellington
Wellington, Kansas, 67152, United States
Associates in Womens Health
Wichita, Kansas, 67203, United States
Cancer Center of Kansas, P.A.
Wichita, Kansas, 67208, United States
Cancer Center of Kansas, P.A. - Wichita
Wichita, Kansas, 67214, United States
CCOP - Wichita
Wichita, Kansas, 67214, United States
Via Christi Cancer Center at Via Christi Regional Medical Center
Wichita, Kansas, 67214, United States
Wesley Medical Center
Wichita, Kansas, 67214, United States
Cancer Center of Kansas - Winfield
Winfield, Kansas, 67156, United States
Baton Rouge General Regional Cancer Center
Baton Rouge, Louisiana, 70806, United States
Mary Bird Perkins Cancer Center - Baton Rouge
Baton Rouge, Louisiana, 70809, United States
Cancer Center at Medical Center of Louisiana - New Orleans
New Orleans, Louisiana, 70112, United States
MBCCOP - LSU Health Sciences Center
New Orleans, Louisiana, 70112, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
Franklin Medical Center
Greenfield, Massachusetts, 01301, United States
Holyoke Medical Center, Incorporated
Holyoke, Massachusetts, 01040, United States
Baystate Regional Cancer Program at D'Amour Center for Cancer Care
Springfield, Massachusetts, 01199, United States
Noble Hospital
Westfield, Massachusetts, 01085, United States
MeritCare Clinic - Bemidji
Bemidji, Minnesota, 56601, United States
Fairview Ridges Hospital
Burnsville, Minnesota, 55337, United States
Mercy Hospital
Coon Rapids, Minnesota, 55433, United States
Fairview Southdale Hospital
Edina, Minnesota, 55435, United States
Mercy and Unity Cancer Center at Mercy and Unity Hospitals
Fridley, Minnesota, 55432, United States
Hutchinson Area Health Care
Hutchinson, Minnesota, 55350, United States
Meeker County Memorial Hospital
Litchfield, Minnesota, 55355, United States
St. John's Hospital
Maplewood, Minnesota, 55109, United States
Virginia Piper Cancer Institute at Abbott-Northwestern Hospital
Minneapolis, Minnesota, 55407, United States
Hennepin County Medical Center - Minneapolis
Minneapolis, Minnesota, 55415, United States
Hubert H. Humphrey Cancer Center at North Memorial Medical Center
Robbinsdale, Minnesota, 55422, United States
Mayo Clinic Cancer Center
Rochester, Minnesota, 55905, United States
CCOP - Metro-Minnesota
Saint Louis Park, Minnesota, 55416, United States
Park Nicollet Clinic
Saint Louis Park, Minnesota, 55416, United States
Cancer Care Center at Regions Hospital
Saint Paul, Minnesota, 55101, United States
St. Joseph's Hospital
Saint Paul, Minnesota, 55102, United States
United Hospital
Saint Paul, Minnesota, 55102, United States
Saint Francis Cancer Center
Shakopee, Minnesota, 55379, United States
Ridgeview Medical Center
Waconia, Minnesota, 55387, United States
Woodwinds Hospital
Woodbury, Minnesota, 55125, United States
CCOP - Northern New Jersey
Hackensack, New Jersey, 07601, United States
Bismarck Cancer Center
Bismarck, North Dakota, 58501, United States
Medcenter One Health System
Bismarck, North Dakota, 58501, United States
Mid Dakota Clinic, P.C.
Bismarck, North Dakota, 58501, United States
St. Alexius Medical Center
Bismarck, North Dakota, 58501, United States
CCOP - MeritCare Hospital
Fargo, North Dakota, 58122, United States
MeritCare Medical Group
Fargo, North Dakota, 58122, United States
St. Elizabeth Boardman Cancer Center
Boardman, Ohio, 44512, United States
St. Rita's Medical Center
Lima, Ohio, 45801, United States
St. Joseph Health Care Center
Warren, Ohio, 44484, United States
St. Elizabeth Cancer Center at St. Elizabeth Health Center - Youngstown
Youngstown, Ohio, 44510, United States
St. Luke's Hospital Cancer Center
Bethlehem, Pennsylvania, 18015, United States
Penn State Cancer Institute at Milton S. Hershey Medical Center
Hershey, Pennsylvania, 17033-0850, United States
Lewistown Hospital
Lewistown, Pennsylvania, 17044, United States
Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111-2497, United States
Mount Nittany Medical Center
State College, Pennsylvania, 16803, United States
Sioux Valley Hospital and University of South Dakota Medical Center
Sioux Falls, South Dakota, 57104, United States
Avera McKennan Hospital and University Health Center
Sioux Falls, South Dakota, 57105, United States
Medical X-Ray Center
Sioux Falls, South Dakota, 57105, United States
Erlanger Cancer Center
Chattanooga, Tennessee, 37403, United States
West Virginia University - Robert C. Byrd Health Sciences Center - Charleston Division
Charleston, West Virginia, 25304, United States
Green Bay Oncology, Limited at St. Vincent Hospital
Green Bay, Wisconsin, 54301-3526, United States
St. Vincent Hospital
Green Bay, Wisconsin, 54301, United States
Green Bay Oncology, Limited at St. Mary's Hospital
Green Bay, Wisconsin, 54303, United States
St. Mary's Hospital Medical Center
Green Bay, Wisconsin, 54303, United States
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601, United States
Bay Area Cancer Care Center at Bay Area Medical Center
Marinette, Wisconsin, 54143, United States
Related Publications (1)
Landry JC, Catalano P, Hoffman J, et al.: ECOG 1200: a randomized phase II trial of gemcitabine plus radiotherapy vs gemcitabine, 5-fluorouracil and cisplatin followed by radiotherapy and 5-fluorouracil in patients with locally advanced, potentially resectable pancreatic adenocarcinoma. [Abstract] Int J Radiat Oncol Biol Phys 66 (3 Suppl 1): A-2111, S272, 2006.
RESULT
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
John Parker Hoffman, MD
Fox Chase Cancer Center
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Sponsor Type
- NETWORK
Study Record Dates
First Submitted
November 12, 2002
First Posted
January 27, 2003
Study Start
October 13, 2003
Primary Completion
October 1, 2005
Study Completion
May 1, 2009
Last Updated
June 15, 2023
Record last verified: 2023-06