NCT00047970

Brief Summary

The Sister Study is prospectively examining environmental and familial risk factors for breast cancer and other diseases in a cohort of 50,884 sisters of women who have had breast cancer. Such sisters have about twice the risk of developing breast cancer as other women.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50,884

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Aug 2003

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

October 23, 2002

Completed
1 day until next milestone

First Posted

Study publicly available on registry

October 24, 2002

Completed
9 months until next milestone

Study Start

First participant enrolled

August 1, 2003

Completed
6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2009

Completed
5.7 years until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2015

Completed
Last Updated

April 15, 2015

Status Verified

November 1, 2012

Enrollment Period

6 years

First QC Date

October 23, 2002

Last Update Submit

April 14, 2015

Conditions

Breast Cancer

Keywords

Breast CancerSisters

Eligibility Criteria

Age35 Years - 74 Years
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Women who are eligible for the Sister Study:
  • Have a sister (living or deceased) who had breast cancer
  • Ages 35-74
  • Never had breast cancer themselves
  • Live in the United States
  • The Sister Study is currently recruiting sisters of women diagnosed with breast cancer nationwide.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

NIEHS

Research Triangle Park, North Carolina, 27514, United States

Location

Related Publications (3)

  • O'Brien KM, Sandler DP. Reply to "Vitamin D and breast cancer: Stop torturing the data!". Cancer. 2022 Aug 1;128(15):3000-3001. doi: 10.1002/cncr.34274. Epub 2022 Jun 1. No abstract available.

    PMID: 35647759DERIVED

  • Kresovich JK, Park YM, Keller JA, Sandler DP, Taylor JA. Healthy eating patterns and epigenetic measures of biological age. Am J Clin Nutr. 2022 Jan 11;115(1):171-179. doi: 10.1093/ajcn/nqab307.

    PMID: 34637497DERIVED

  • Petimar J, Park YM, Smith-Warner SA, Fung TT, Sandler DP. Dietary index scores and invasive breast cancer risk among women with a family history of breast cancer. Am J Clin Nutr. 2019 May 1;109(5):1393-1401. doi: 10.1093/ajcn/nqy392.

    PMID: 30968114DERIVED

Related Links

MeSH Terms

Conditions

Breast Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by SiteNeoplasmsBreast DiseasesSkin DiseasesSkin and Connective Tissue Diseases

Study Design

Study Type
observational
Time Perspective
PROSPECTIVE
Sponsor Type
NIH
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Chief, Epidemiology Branch, DIR

Study Record Dates

First Submitted

October 23, 2002

First Posted

October 24, 2002

Study Start

August 1, 2003

Primary Completion

August 1, 2009

Study Completion

April 1, 2015

Last Updated

April 15, 2015

Record last verified: 2012-11

Locations

US(1)