NCT00044629

Brief Summary

This study will determine how sleeping pills can be combined with nondrug treatments to maximize the benefits of therapy for insomnia.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
162

participants targeted

Target at P75+ for phase_2

Timeline
Completed

Started Sep 2001

Longer than P75 for phase_2

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2001

Completed
1 year until next milestone

First Submitted

Initial submission to the registry

September 3, 2002

Completed
2 days until next milestone

First Posted

Study publicly available on registry

September 5, 2002

Completed
3.9 years until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2006

Completed
Last Updated

September 16, 2013

Status Verified

September 1, 2013

First QC Date

September 3, 2002

Last Update Submit

September 12, 2013

Conditions

Keywords

Sleep DeprivationInsomniaSleep Disorders

Study Arms (3)

Cognitive Behavioral Therapy and Ambien

EXPERIMENTAL

Cognitive Behavioral Therapy and Ambien

Behavioral: Cognitive-Behavioral Therapy for InsomniaDrug: zolpidem tartrate (Ambien)

Cognitive Behavioral Therapy and Placebo

PLACEBO COMPARATOR

Cognitive Behavioral Therapy and Placebo

Behavioral: Cognitive-Behavioral Therapy for InsomniaDrug: Placebo

Cognitive Behavioral Therapy alone (no drug)

ACTIVE COMPARATOR

Cognitive Behavioral Therapy alone (no drug)

Behavioral: Cognitive-Behavioral Therapy for Insomnia

Interventions

Cognitive Behavioral Therapy alone (no drug)Cognitive Behavioral Therapy and AmbienCognitive Behavioral Therapy and Placebo
Cognitive Behavioral Therapy and Ambien
Cognitive Behavioral Therapy and Placebo

Eligibility Criteria

Age21 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • be between 21 and 75 years of age
  • have a mean total nocturnal wake time of \> 60 min./night
  • have a history of insomnia \> 6 months
  • have a history of one or more poor sleep hygiene practices such as taking 3 or more naps/week, varying bed times or wake times by \> 2 hrs. from day to day, or routinely lying in bed awake for periods \> 30 min

You may not qualify if:

  • pregnant women
  • the terminally ill
  • individuals with other medical conditions (e.g. chronic pain disorders, etc.) that compromise sleep
  • individuals with major psychiatric diagnoses
  • persons with hypnotic-dependent insomnia
  • subjects on antidepressants or anxiolytics
  • subjects with evidence of sleep apnea

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Duke Sleep Disorders Center

Durham, North Carolina, 27710, United States

Location

MeSH Terms

Conditions

Sleep Initiation and Maintenance DisordersSleep DeprivationSleep Wake Disorders

Interventions

Cognitive Behavioral TherapyZolpidem

Condition Hierarchy (Ancestors)

Sleep Disorders, IntrinsicDyssomniasNervous System DiseasesMental DisordersNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Behavior TherapyPsychotherapyBehavioral Disciplines and ActivitiesPyridinesHeterocyclic Compounds, 1-RingHeterocyclic Compounds

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
DOUBLE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 3, 2002

First Posted

September 5, 2002

Study Start

September 1, 2001

Study Completion

August 1, 2006

Last Updated

September 16, 2013

Record last verified: 2013-09

Locations