Parkinson's Diseases Susceptibility Genes and Pesticides

NCT00044590 | Completed

• 1 other identifier: 10544-CP-001
• Study Type: observational
• Target: 1,870
• Locations: 1 country
• Sites: 1

Brief Summary

Parkinson's disease (PD) occurrence is higher in rural than in urban populations of industrialized countries. Epidemiologic and human tissue studies suggest that pesticides may be responsible for causing dopaminergic cell death at increased rates. While many pathophysiologic pathways may be involved in the neurodegeneration responsible for PD, genetic factors are likely to determine a general susceptibility to neurodegeneration.

Conditions

Parkinson's Disease

Keywords

Parkinson's disease; Pesticides; Genetic susceptibility; Polymorphisms

Study Arms (2)

Cases

Patients with Parkinson's Disease

Controls

Controls, subjects without Parkinson's Disease

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Our case population consists of patients with newly diagnosed idiopathic Parkinson's disease living in central California; they will be patients who have elicited care from health care providers. Controls will be randomly selected from Medicare records and matched to cases according to age, race, and sex.

You may qualify if:

• first Parkinson's disease (PD) diagnosis after January 1998
• currently living in one of the three target counties (Kern, Tulare, Fresno)
• have lived in California for at least 5 years

You may not qualify if:

• have not been diagnosed with idiopathic PD
• first PD diagnosis before January 1998
• currently living outside of Kern, Tulare, or Fresno counties
• have lived in California for fewer than 5 years
• have never been diagnosed with PD
• currently living in one of the three target counties (Kern, Tulare, Fresno)
• have lived in California for at least 5 years
• have been diagnosed with PD
• currently living outside of Kern, Tulare, or Fresno counties
• have lived in California for fewer than 5 years
• For each patient, one or more unaffected sibling controls and one population control will be recruited. The population control are being selected randomly from Medicare records (95% of all controls) and residential parcel listings (for those patients younger than 65 years of age only). The controls are being marginally matched to cases according to 5-year age categories (e.g. 50-54, 55-59, 60-64, etc.), race (white, African-American, Asian, Hispanic, other), and sex. All study cases by definition will be patients who elicited care from health care providers. We are aiming to enroll every newly diagnosed PD patient into our study and expect patient population participating in our study that is as diverse as the rural population.

Sponsors & Collaborators

• National Institute of Environmental Health Sciences (NIEHS): lead
• University of California, Los Angeles: collaborator

Study Sites (1)

Beate Ritz, UCLA Department of Epidemiology

Los Angeles, California, 90095-1772, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

Blood, saliva, urine, and stool samples

MeSH Terms

Conditions

Parkinson Disease; Genetic Predisposition to Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Disease Susceptibility; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Beate Ritz, MD, PhD

  UCLA Department of Epidemiology

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: OTHER
• Sponsor Type: NIH
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: September 3, 2002
• First Posted: September 5, 2002
• Study Start: September 1, 2000
• Primary Completion: November 30, 2016
• Study Completion: November 30, 2016
• Last Updated: May 16, 2017

Record last verified: 2017-05

Locations

US (1)