Characterization of Childhood-Onset Obsessive-Compulsive Disorder

NCT00044239 | Completed

• 2 other identifiers: 02028102-M-0281
• Study Type: observational
• Target: 49
• Locations: 1 country
• Sites: 4

Brief Summary

The purpose of this study is to learn more about Obsessive-compulsive Disorder (OCD) in children. OCD usually has a slow onset, and symptoms that may remain at a stable level over time. A subset of children with OCD has a sudden onset and symptoms that fluctuate in severity over time. This study will also compare healthy children to those with OCD. This is an observational study; children who participate will not receive any new or experimental therapies. OCD affects nearly 1% of the pediatric population. The symptoms of this illness can interrupt development, causing significant psychological distress and producing life-long impairments in social, academic, and occupational functioning. A subgroup of pediatric OCD has been designated by the acronym PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections). This type of OCD is characterized by sudden symptom onset and a relapsing-remitting course of illness; exacerbation of symptoms occurs with scarlet fever or strep. throat infections. This study will identify factors that distinguish children with PANDAS OCD from children with non-PANDAS OCD, and will compare both groups to healthy children. Children with OCD and their parents are screened with interviews and a review of the child's medical records. Participants have an initial evaluation that includes a psychiatric, physical and neuromotor exam, neuropsychological testing, psychological interviews, and a blood test. Structural magnetic resonance imaging (MRS) scans of the brain are also obtained. The MRS scan does not use radiation. After the initial evaluation, children with OCD have follow-up visits every 6 weeks for 12 to 24 months. They are seen yearly for 8 years after the study. If they have a significant improvement or worsening of their symptoms, they are asked to make a maximum of two extra visits. Parents of OCD patients are called four times a year to discuss any changes in the child's condition between yearly visits. All participants have a 1-year follow-up visit upon study completion.

Conditions

Obsessive-Compulsive Disorder

Keywords

Tic Disorders; Neurophyschological; Immunology; Magnetic Resonance Imaging; Basal Ganglia; Obsessive-Compulsive Disorder; Children; Adolescents; Magnetic Resonance Spectroscopy; PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated d; Obsessive Compulsive Disorder; OCD; Healthy Volunteers; HV

Eligibility Criteria

• Age: 4 Years - 12 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• OCD Participants (N = 72)
• Aged 4-12 years and living within a four-hour commute from NIH
• Currently meet DSM-IV criteria for OCD.
• Recent onset of symptoms (less than 6 months.)
• Healthy Controls (N = 60-72)
• Age and sex matched to ODC participants.
• Must be free of current or past psychopathology.

You may not qualify if:

• OCD Participants:
• Diagnosis of schizophrenia, schizoaffective, bipolar, delusional, or psychotic disorder; autistic spectrum disorder or pervasive developmental disorder; neurologic disorder other than tics; or rheumatic fever.
• Significant or unstable medical illness.
• Full scale IQ less than 80.
• Healthy Controls:
• Full scale IQ less than 80.
• Significant or unstable medical illness.

Sponsors & Collaborators

• National Institute of Mental Health (NIMH): lead

Study Sites (4)

University of Arkansas

Little Rock, Arkansas, 72205, United States

Location

University of Florida

Gainesville, Florida, 32610-0296, United States

Location

Cornell University

New York, New York, 10021-4872, United States

Location

Utah State University

Logan, Utah, 84322, United States

Location

Related Publications (3)

• Rosenberg DR, Keshavan MS, O'Hearn KM, Dick EL, Bagwell WW, Seymour AB, Montrose DM, Pierri JN, Birmaher B. Frontostriatal measurement in treatment-naive children with obsessive-compulsive disorder. Arch Gen Psychiatry. 1997 Sep;54(9):824-30. doi: 10.1001/archpsyc.1997.01830210068007.

  PMID: 9294373 BACKGROUND

• Snider LA, Lougee L, Slattery M, Grant P, Swedo SE. Antibiotic prophylaxis with azithromycin or penicillin for childhood-onset neuropsychiatric disorders. Biol Psychiatry. 2005 Apr 1;57(7):788-92. doi: 10.1016/j.biopsych.2004.12.035.

  PMID: 15820236 BACKGROUND

• Saxena S, Brody AL, Schwartz JM, Baxter LR. Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder. Br J Psychiatry Suppl. 1998;(35):26-37.

  PMID: 9829024 BACKGROUND

MeSH Terms

Conditions

Obsessive-Compulsive Disorder; Tic Disorders; Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections

Condition Hierarchy (Ancestors)

Anxiety Disorders; Mental Disorders; Movement Disorders; Central Nervous System Diseases; Nervous System Diseases; Neurodevelopmental Disorders

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: August 22, 2002
• First Posted: August 23, 2002
• Study Start: August 20, 2002
• Study Completion: May 18, 2010
• Last Updated: July 2, 2017

Record last verified: 2010-05-18

Locations

US (4)