Health Effects of Early-Life Exposure to Urban Pollutants in Minority Children

NCT00043498 | Completed DMC

• 1 other identifier: 8977-CP-001
• Study Type: observational
• Target: 727
• Locations: 1 country
• Sites: 1

Brief Summary

A molecular epidemiologic study of African American and Hispanic mothers and newborns to investigate the role of common urban pollutants on procarcinogenic and developmental damage.

Conditions

Asthma; Development

Keywords

Pollutants

Outcome Measures

Primary Outcomes (2)

• Neurobehavioral development

  1 to 12 years

• Asthma

  2-12 years

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The present study enrolled 727 African American and Latino (Dominican) mothers and their children. The African American and Latino (Dominican) women were initially enrolled into the parent CCCEH study during pregnancy. Caucasian women are not included because a central purpose of the research is to evaluate health outcomes in a high risk, minority population.

Enrollment eligibility was restricted to nonsmoking pregnant women 18-35 years of age who self-identified as either African American or Dominican and who had resided in northern Manhattan or the South Bronx in New York City for at least 1 year before pregnancy. Women were excluded if they used illicit drugs, had diabetes, hypertension, or known HIV, or had their first prenatal visit after the 20th week of pregnancy.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Institute of Environmental Health Sciences (NIEHS): lead

Study Sites (1)

Columbia University, 722 W 168th St, 12th Floor

New York, New York, 10032, United States

Location

Related Publications (1)

• Widen EM, Whyatt RM, Hoepner LA, Ramirez-Carvey J, Oberfield SE, Hassoun A, Perera FP, Gallagher D, Rundle AG. Excessive gestational weight gain is associated with long-term body fat and weight retention at 7 y postpartum in African American and Dominican mothers with underweight, normal, and overweight prepregnancy BMI. Am J Clin Nutr. 2015 Dec;102(6):1460-7. doi: 10.3945/ajcn.115.116939. Epub 2015 Oct 21.

  PMID: 26490495 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

We collected maternal urine during the third trimester of pregnancy, maternal blood at delivery, umbilical cord blood, meconium, blood and urine from the child at ages 24, 36, and 60 months.

MeSH Terms

Conditions

Asthma

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Officials

• Frederica P Perera, DrPH, PhD

  Columbia University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 9, 2002
• First Posted: August 12, 2002
• Study Start: August 1, 1997
• Primary Completion: May 1, 2013
• Study Completion: May 1, 2013
• Last Updated: October 15, 2014

Record last verified: 2014-10

Locations

US (1)