NCT00041821

Brief Summary

This study seeks to document differences in nasal irritant sensitivity within the population. The investigators are interested in knowing whether age, gender, and allergy status (nasal allergies) predict nasal irritant sensitivity. This is important in understanding symptom reporting patterns in air pollution situations (particularly in so-called "problem buildings"), as well as in understanding the reflex mechanism of a response of the nose to irritants (e.g., nasal congestion).

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
64

participants targeted

Target at P50-P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2000

Completed
1.9 years until next milestone

First Submitted

Initial submission to the registry

July 18, 2002

Completed
4 days until next milestone

First Posted

Study publicly available on registry

July 22, 2002

Completed
Last Updated

March 23, 2006

Status Verified

March 1, 2006

First QC Date

July 18, 2002

Last Update Submit

March 22, 2006

Conditions

Rhinitis, Allergic, Nonseasonal

Keywords

rhinitisirritationtrigeminal

Interventions

Nasal irritation thresholds and irritant provocationPROCEDURE

Eligibility Criteria

Age18 Years - 69 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Non-smokers
  • years of age
  • With or without allergic rhinitis (hay fever)
  • In good general health and with no prior history of asthma

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Upper Airway Biology Laboratory

Richmond, California, 94804, United States

Location

Related Publications (2)

  • Shusterman DJ, Murphy MA, Balmes JR. Subjects with seasonal allergic rhinitis and nonrhinitic subjects react differentially to nasal provocation with chlorine gas. J Allergy Clin Immunol. 1998 Jun;101(6 Pt 1):732-40. doi: 10.1016/S0091-6749(98)70302-1.

    PMID: 9648699BACKGROUND

  • Shusterman D, Murphy MA, Balmes J. The influence of sex, allergic rhinitis, and test system on nasal sensitivity to airborne irritants: a pilot study. Environ Health Perspect. 2001 Jan;109(1):15-9. doi: 10.1289/ehp.0110915.

    PMID: 11171519BACKGROUND

Related Links

MeSH Terms

Conditions

Rhinitis, Allergic, PerennialRhinitis

Condition Hierarchy (Ancestors)

Rhinitis, AllergicNose DiseasesRespiratory Tract DiseasesRespiratory HypersensitivityOtorhinolaryngologic DiseasesHypersensitivity, ImmediateHypersensitivityImmune System DiseasesRespiratory Tract InfectionsInfections

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Intervention Model
CROSSOVER
Sponsor Type
NIH

Study Record Dates

First Submitted

July 18, 2002

First Posted

July 22, 2002

Study Start

September 1, 2000

Last Updated

March 23, 2006

Record last verified: 2006-03

Locations

US(1)